Which Dendrimer to Attain the Desired Properties? Focus on Phosphorhydrazone Dendrimers

Caminade, Anne‐Marie; Majoral, Jean‐Pierre

doi:10.3390/molecules23030622

Cited by 20 publications

(13 citation statements)

References 56 publications

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“…One of the inorganic branching points of dendrimers is the phosphorous-generating the family of “Phosphorhydrazone dendrimers”. Terminal functions can have positive charges (ammonium) or negative charges (phosphonates) [ 33 ]. These structures are presented in Figure 9 .…”

Section: Biomedical Applications Of Dendrimersmentioning

confidence: 99%

“… The structures of phosphorhydrazone dendrimers with charged terminal functions: positive ( a ) and negative ( b ). Adapted from [ 33 ], published by Molecules 2018. …”

Section: Figurementioning

confidence: 99%

“…In order to obtain a better understanding of these compounds, the synthesis and physicochemical analysis of dendrimers were reviewed as well [ 31 , 32 ]. Different types of dendrimers were compared from biological points of view, thus underlining their properties depending on their composition [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

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Applications and Limitations of Dendrimers in Biomedicine

et al. 2020

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Biomedicine represents one of the main study areas for dendrimers, which have proven to be valuable both in diagnostics and therapy, due to their capacity for improving solubility, absorption, bioavailability and targeted distribution. Molecular cytotoxicity constitutes a limiting characteristic, especially for cationic and higher-generation dendrimers. Antineoplastic research of dendrimers has been widely developed, and several types of poly(amidoamine) and poly(propylene imine) dendrimer complexes with doxorubicin, paclitaxel, imatinib, sunitinib, cisplatin, melphalan and methotrexate have shown an improvement in comparison with the drug molecule alone. The anti-inflammatory therapy focused on dendrimer complexes of ibuprofen, indomethacin, piroxicam, ketoprofen and diflunisal. In the context of the development of antibiotic-resistant bacterial strains, dendrimer complexes of fluoroquinolones, macrolides, beta-lactamines and aminoglycosides have shown promising effects. Regarding antiviral therapy, studies have been performed to develop dendrimer conjugates with tenofovir, maraviroc, zidovudine, oseltamivir and acyclovir, among others. Furthermore, cardiovascular therapy has strongly addressed dendrimers. Employed in imaging diagnostics, dendrimers reduce the dosage required to obtain images, thus improving the efficiency of radioisotopes. Dendrimers are macromolecular structures with multiple advantages that can suffer modifications depending on the chemical nature of the drug that has to be transported. The results obtained so far encourage the pursuit of new studies.

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Section: Biomedical Applications Of Dendrimersmentioning

confidence: 99%

“… The structures of phosphorhydrazone dendrimers with charged terminal functions: positive ( a ) and negative ( b ). Adapted from [ 33 ], published by Molecules 2018. …”

Section: Figurementioning

confidence: 99%

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Applications and Limitations of Dendrimers in Biomedicine

et al. 2020

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“…However, interaction through electrostatic surface charges is not the only mechanism whereby NPs lead to platelet aggregation, and each nanosystem must be investigated as an independent case [60]. Amongst the different nanosystems, dendrimers stand out in terms of their ability to induce platelet aggregation; numerous types of dendrimers, including polyamiodamine (PAMAM), polypropyleneimine (PPI), triazine and carbosilane dendrimers, have been found to cause aggressive thrombus formation [61]. PAMAM dendrimers specifically have been extensively studied for their hemotoxicity and effects on blood platelets, especially after Greish et al found amine-terminated PAMAM dendrimers to cause a lethal, disseminated intravascular coagulation-like condition in CD1 mice [62].…”

Section: Platelet Function In Hemostasis and The Mechanisms Involvmentioning

confidence: 99%

The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis

Harpe

Kondiah

Choonara

et al. 2019

Cells

250

143

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Understanding cell–nanoparticle interactions is critical to developing effective nanosized drug delivery systems. Nanoparticles have already advanced the treatment of several challenging conditions including cancer and human immunodeficiency virus (HIV), yet still hold the potential to improve drug delivery to elusive target sites. Even though most nanoparticles will encounter blood at a certain stage of their transport through the body, the interactions between nanoparticles and blood cells is still poorly understood and the importance of evaluating nanoparticle hemocompatibility is vastly understated. In contrast to most review articles that look at the interference of nanoparticles with the intricate coagulation cascade, this review will explore nanoparticle hemocompatibility from a cellular angle. The most important functions of the three cellular components of blood, namely erythrocytes, platelets and leukocytes, in hemostasis are highlighted. The potential deleterious effects that nanoparticles can have on these cells are discussed and insight is provided into some of the complex mechanisms involved in nanoparticle–blood cell interactions. Throughout the review, emphasis is placed on the importance of undertaking thorough, all-inclusive hemocompatibility studies on newly engineered nanoparticles to facilitate their translation into clinical application.

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“…[92]. Carbon nanotubes are graphite sheets rolled up into a tubular form in which drugs are filled [93].…”

Section: Nanoparticles As Vehicles For Gene Deliverymentioning

confidence: 99%

Nanomedicine for Gene Delivery for the Treatment of Cardiovascular Diseases

Yan

Quan

Feng

2019

CGT

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Background: Myocardial infarction (MI) is the most severe ischemic heart disease and directly leads to heart failure till death. Target molecules have been identified in the event of MI including increasing angiogenesis, promoting cardiomyocyte survival, improving heart function and restraining inflammation and myocyte activation and subsequent fibrosis. All of which are substantial in cardiomyocyte protection and preservation of cardiac function. Methodology: To modulate target molecule expression, virus and non-virus-mediated gene transfer have been investigated. Despite successful in animal models of MI, virus-mediated gene transfer is hampered by poor targeting efficiency, low packaging capacity for large DNA sequences, immunogenicity induced by virus and random integration into the human genome. Discussion: Nanoparticles could be synthesized and equipped on purpose for large-scale production. They are relatively small in size and do not incorporate into the genome. They could carry DNA and drug within the same transfer. All of these properties make them an alternative strategy for gene transfer. In the review, we first introduce the pathological progression of MI. After concise discussion on the current status of virus-mediated gene therapy in treating MI, we overview the history and development of nanoparticle-based gene delivery system. We point out the limitations and future perspective in the field of nanoparticle vehicle. Conclusion: Ultimately, we hope that this review could help to better understand how far we are with nanoparticle-facilitated gene transfer strategy and what obstacles we need to solve for utilization of nanomedicine in the treatment of MI.

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Which Dendrimer to Attain the Desired Properties? Focus on Phosphorhydrazone Dendrimers

Cited by 20 publications

References 56 publications

Applications and Limitations of Dendrimers in Biomedicine

Applications and Limitations of Dendrimers in Biomedicine

The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis

Nanomedicine for Gene Delivery for the Treatment of Cardiovascular Diseases

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