Which Drug Prevents Tachycardia and Hypertension Associated with Tracheal Intubation

Helfman, S. M.; Gold, Martin I.; Delisser, E. A.; Herrington, Claire

doi:10.1097/00132586-199110000-00016

Cited by 31 publications

(42 citation statements)

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“…15,16 Different pharmacologic agents like lidocaine, vasodilator agents inhibiting sympathoadrenal response, α and β adrenergic blockers, and opioids can be administered prior to tracheal intubation in order to prevent haemodynamic responses (Helfman et al; Mikawa et al). 4,17 In present study at baseline all the groups were matched for haemodynamic parameters and did not show a significant intergroup difference. However, immediately after injection of test drug (1 minute after test drug) both the test groups showed a significant decrease in SBP (systolic blood pressure) and heart rate.…”

Section: Discussionmentioning

confidence: 66%

“…3 Different pharmacologic agents like lidocaine, vasodilator agents inhibiting sympathoadrenal response, α-and β-adrenergic blockers, and opioids can be administered prior to tracheal intubation in order to prevent hemodynamic responses. ( [4][5][6][7][8] β-blockers are used to reduce the necessity of anaesthetic drugs by their sedative properties and reduce unwanted hemodynamic responses.…”

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confidence: 99%

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A randomized, controlled study to compare the effects of intravenous labetalol and esmolol on haemodynamic changes during laryngoscopy and intubation

2017

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Background: Direct laryngoscopy and endotracheal intubation frequently induce cardiovascular stress response characterised by hypertension and tachycardia due to reflex sympathetic stimulation. Considering the clinical significance of these changes stress attenuation is needed to blunt these responses. β- blockers are used to reduce the unwanted hemodynamic responses. Esmolol is ultra-short acting cardio selective β blocker. Labetalol is useful in not only attenuating the response to laryngoscopy and intubation but also in preventing perioperative cardiovascular events. Present study compared the efficacy of esmolol and labetalol for attenuation of sympathomimetic response to laryngoscopy and intubation.Methods: It was a prospective, randomized, controlled study carried out in 75 adult patients with ASA 1 and ASA 2 posted for elective surgeries. Patients were allocated randomly into Group-1 (esmolol) and Group-2 (labetalol) and Group-3 (placebo) of 25 patients each. Inj. esmolol (1mg/kg) or Inj. labetalol (0.4 mg/kg) or placebo (0.9NS) dissolved up to 5 ml in distilled water was injected intravenously 5 minutes prior to intubation. All patients premeditated with Inj. glycopyrrolate (4µg/kg). Patient were then induced with Inj. propofol (2mg/kg), Inj. scoline (2mg/kg) given followed by laryngoscopy and intubation. Haemodynamic readings were noted at T0 (baseline before injecting the drug), T1 (1 minute after injecting the drug), T2 (after intubation), T3 (2 minutes after intubation), T4 (4 minutes after intubation), T5 (6 minutes after intubation), T6 (8 minutes after injection), T7 (10 minutes after injection).Results: Gr-1, Gr-2 and Gr-3, when compared with each other for systolic BP, diastolic BP, mean BP, and HR, showed a statistically significant difference at different intervals.Conclusions: Both the drugs are found to be effective in attenuation of hemodynamic reflex without any side effects. Further studies are recommended to substantiate the findings in present study.

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Section: Discussionmentioning

confidence: 66%

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confidence: 99%

A randomized, controlled study to compare the effects of intravenous labetalol and esmolol on haemodynamic changes during laryngoscopy and intubation

2017

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“…Helfman ve ark. (11) , esmololün 1,5 mg/ kg dozda uygulandığında SAB'da % 19, KAH'da % 18 kadar azalmaya neden olduğunu bildirmiştir. Singh ve ark.…”

Section: Discussionunclassified

Effect of Esmolol on Hemodynamic Response to Tracheal Intubation in Hyper- and Normotensive Patients

Ökten¹,

Ceyhan²,

Sabuncu³

2011

J Turk Anaesth Int Care

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“…Methods to attenuate these responses, both pharmacological and otherwise, have also been studied. [3][4][5] The video laryngoscope as shown in Figure 1 was a new airway tool, which was developed to address difficult airway. The Pentax airway scope (AWS), is a batteryoperated video laryngoscope, first introduced in 2006, had shown promising results in patients with difficult airways.…”

Section: Introductionmentioning

confidence: 99%

Haemodynamic response to endotrachial intubation: direct versus video laryngoscopy

et al. 2016

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Which Drug Prevents Tachycardia and Hypertension Associated with Tracheal Intubation

Cited by 31 publications

References 0 publications

A randomized, controlled study to compare the effects of intravenous labetalol and esmolol on haemodynamic changes during laryngoscopy and intubation

A randomized, controlled study to compare the effects of intravenous labetalol and esmolol on haemodynamic changes during laryngoscopy and intubation

Effect of Esmolol on Hemodynamic Response to Tracheal Intubation in Hyper- and Normotensive Patients

Haemodynamic response to endotrachial intubation: direct versus video laryngoscopy

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