Which elements of a comprehensive geriatric assessment (CGA) predict post-operative complications and early mortality after colorectal cancer surgery?

Kristjansson, Siri Rostoft; Jordhøy, Marit S.; Nesbakken, Arild; Skovlund, Eva; Bakka, Arne; Johannessen, Hans-Olaf; Wyller, Torgeir Bruun

doi:10.1016/j.jgo.2010.06.001

Cited by 85 publications

(92 citation statements)

References 39 publications

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“…We have previously shown that comorbidity, IADLdependency, and depression are CGA-elements that independently predict post-operative complications. 29 As PF does not include comorbidity or psychological factors, its usefulness in the pre-operative setting may be limited. Contrary to our results, a recent publication found that the criteria comprising PF predicted post-operative complications in a heterogeneous cohort of surgical patients aged 65 years or older.…”

Section: Discussionmentioning

confidence: 99%

A comparison of two pre-operative frailty measures in older surgical cancer patients

Kristjansson

Rønning

Hurria

et al. 2012

Journal of Geriatric Oncology

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Section: Discussionmentioning

confidence: 99%

A comparison of two pre-operative frailty measures in older surgical cancer patients

Kristjansson

Rønning

Hurria

et al. 2012

Journal of Geriatric Oncology

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“…In a prospective study of 182 patients aged 70 years and older undergoing elective CRC surgery, being frail was associated with an increased risk of postoperative complications and poor 5-year survival [14,19]. The domains of the GA that independently predicted poor outcomes were severe comorbidity, functional impairment, depression, and malnutrition [21]. The patients were assessed 16-28 months after surgery, and many experienced a decline in functional status measured by activities of daily living (ADL) [22].…”

Section: Geriatric Assessment and Colorectal Cancermentioning

confidence: 99%

Integration of Geriatric Assessment in the Care of Patients with Gastrointestinal Malignancies

Rostoft

2017

Visc Med

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Background: The majority of patients with gastrointestinal (GI) malignancies are older. Recently, it has become evident that elements from a geriatric assessment (GA) are powerful predictors of outcomes such as postoperative morbidity and mortality, length of stay, type of treatment received, and survival across several GI tumor types in older adults. A GA is a systematic evaluation of functional status, comorbidities, polypharmacy, cognition, nutritional status, emotional status, and social support. Methods: A PubMed search was performed in order to identify clinical studies investigating the association between GA and outcomes in patients with GI malignancies. Results: A total of 31 studies were included in this review. For colorectal cancer, the evidence linking GA variables and frailty to negative outcomes is substantial and consistent. The data regarding other GI malignancies is more limited, but generally shows the same findings. Conclusion: Increasing data shows that elements from a GA and frailty are consistently associated with negative short- and long-term treatment outcomes in older patients with GI malignancies. Future studies should investigate the impact of geriatric interventions on outcomes.

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“…For comorbidity, initial analysis revealed that only 6 out of 16 studies found an association with mortality (38%). However, when subdividing according to the assessment method used, only one out of five studies using the Charlson comorbidity index [38] and none of the four studies using the number of comorbid conditions found an association, while four out of five studies using the Cumulative Illness Rating Scale for Geriatrics (CIRS-G) found comorbidity to be associated with mortality (80%) [33,50,53,60,65]. For one study, the results for comorbidity were not clearly reported.…”

Section: All-cause Mortalitymentioning

confidence: 99%

The Value of Geriatric Assessments in Predicting Treatment Tolerance and All-Cause Mortality in Older Patients With Cancer

Hamaker¹,

et al. 2012

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After completing this course, the reader will be able to:1. Describe the predictive value of geriatric assessments for survival in older cancer patients.2. Describe the predictive value of geriatric assessments for treatment tolerance (such as toxicity of chemotherapy and perioperative complications) in older cancer patients. Explain the concept of frailty compared to individual geriatric conditions.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACTBackground. Awareness of the use of geriatric assessments for older patients with cancer is increasing. The aim of this review is to summarize all available evidence on the association between geriatric assessments and relevant oncologic outcomes. Method. A systematic search was conducted in Medline and Embase of studies on geriatric assessment in oncology, focusing on the association between baseline assessment and outcome.Results. The literature search identified 2008 reports; 51 publications from 37 studies were selected for inclu-

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Which elements of a comprehensive geriatric assessment (CGA) predict post-operative complications and early mortality after colorectal cancer surgery?

Cited by 85 publications

References 39 publications

A comparison of two pre-operative frailty measures in older surgical cancer patients

A comparison of two pre-operative frailty measures in older surgical cancer patients

Integration of Geriatric Assessment in the Care of Patients with Gastrointestinal Malignancies

The Value of Geriatric Assessments in Predicting Treatment Tolerance and All-Cause Mortality in Older Patients With Cancer

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