Which features of Parkinson's disease predict earlier exit from the workforce?

Armstrong, Melissa J.; Gruber‐Baldini, Ann L.; Reich, Stephen G.; Fishman, Paul S.; Lachner, Christian; Shulman, Lisa M.

doi:10.1016/j.parkreldis.2014.08.005

Cited by 28 publications

(20 citation statements)

References 10 publications

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“…These findings are consistent with several other included studies showing negative associations between age, disease duration and time in employment after disease onset [e.g. 12,14,15,18,19]. Two studies made a distinction between full-time and part-time employment.…”

Section: Number Of Pd Patients In the Workforcesupporting

confidence: 91%

“…Employed PD patients were more worried that they would not have sufficient money in the future compared to unemployed patients [16]. These worries are supported by findings showing that patients who left the workforce had a lower income than employed patients [18]. Also, patients who were younger than the age of 60 received a lower monthly income than individuals without PD of a similar age [13].…”

Section: Direct and Indirect Costsmentioning

confidence: 99%

“…According to 18%e49% of patients, fatigue is the most debilitating non-motor symptom in relation to the ability to work, followed by stress intolerance (11.5%e35.6%), impaired memory and concentration (14.1%), lack of confidence (7.0%), anxiety and panic attacks (4.4%), depression (3.1%) and visual problems (2.2% [12,14e16,22]). Also when directly comparing PD patients who left the workforce to patients who are still employed, it was found that the former group reported more symptoms of depression and anxiety, a higher level of psychiatric distress, a decreased mental health related quality of life, a lower vitality and more difficulties with social and emotional functioning than employed patients [16,18]. Consistent with these findings, Schrag and colleagues [19] revealed that young-onset PD patients reported more symptoms of depression than older-onset patients.…”

Section: Non-motor Symptomsmentioning

confidence: 99%

See 2 more Smart Citations

Working capacity of patients with Parkinson's disease – A systematic review

Koerts¹,

König²,

Tucha

et al. 2016

Parkinsonism & Related Disorders

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Section: Number Of Pd Patients In the Workforcesupporting

confidence: 91%

Section: Direct and Indirect Costsmentioning

confidence: 99%

Section: Non-motor Symptomsmentioning

confidence: 99%

See 1 more Smart Citation

Working capacity of patients with Parkinson's disease – A systematic review

Koerts¹,

König²,

Tucha

et al. 2016

Parkinsonism & Related Disorders

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show abstract

“…The authors identified the following milestones in PD progression that are likely important from the patient perspective: being able to continue living at home, being able to drive a car, work until retirement, retaining cognitive function, remaining ambulatory, or not dying prematurely [15,16].…”

Section: Clinically Meaningful Markers Of Disease Progression and Lonmentioning

confidence: 99%

Clinically meaningful parameters of progression and long-term outcome of Parkinson disease: An international consensus statement

Puschmann

Brighina

Μarkopoulou

et al. 2015

Parkinsonism & Related Disorders

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Parkinson disease (PD) is associated with a clinical course of variable duration, severity, and a combination of motor and non-motor features. Recent PD research has focused primarily on etiology rather than clinical progression and long-term outcomes. For the PD patient, caregivers, and clinicians, information on expected clinical progression and long-term outcomes is of great importance. Today, it remains largely unknown what factors influence long-term clinical progression and outcomes in PD; recent data indicate that the factors that increase the risk to develop PD differ, at least partly, from those that accelerate clinical progression and lead to worse outcomes. Prospective studies will be required to identify factors that influence progression and outcome. We suggest that data for such studies is collected during routine office visits in order to guarantee high external validity of such research. We report here the results of a consensus meeting of international movement disorder experts from the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium, who convened to define which long-term outcomes are of interest to patients, caregivers and clinicians, and what is presently known about environmental or genetic factors influencing clinical progression or long-term outcomes in PD. We propose a panel of rating scales that collects a significant amount of phenotypic information, can be performed in the routine office visit and allows international standardization. Research into the progression and long-term outcomes of PD aims at providing individual prognostic information early, adapting treatment choices, and taking specific measures to provide care optimized to the individual patient's needs.

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“…A possible underlying factor may be differences in employment patterns between men and women with PD. A recent study on this topic demonstrated that PD patients who leave the workforce early are more likely to be female [19]. If this were true in our population, women would have a greater need for Medicare than men, as they would be less likely to be covered by an employer-based private insurance plan.…”

Section: Discussionmentioning

confidence: 84%

Exploring Gender-Associated Socioeconomic Differences in Parkinson’s Disease

McInnis¹,

Cavanaugh²,

Weinberg³

et al. 2015

APD

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Background: Research on gender in Parkinson's disease (PD) frequently focuses on clinical differences between men and women. Socioeconomic factors such as race, ethnicity, insurance type, and level of educational attainment, have not been extensively examined in relation to gender differences in PD. The goal of this study was to identify differences in PD presentation in men and women, and identify socioeconomic factors that may confound such differences. Methods: A movement disorder patient database containing 445 patients with idiopathic PD was analyzed for gender differences in motor symptoms and disease complications using linear or logistic regression. Socioeconomic variables were then evaluated as possible confounders. Results: A greater proportion of women were non-white (p < 0.05). Univariate analysis of gender, and multivariate analysis controlling for age at diagnosis and socioeconomic factors were concordant in demonstrating increased frequency of motor fluctuations and dyskinesia in women (p < 0.05). Controlled, multivariate analysis, when compared to univariate analysis, uniquely demonstrated that women were less likely to experience dementia and autonomic dysfunction, relative to men (p < 0.05). Conclusion: Women with PD are susceptible to motor fluctuations and dyskinesia, but may be relatively protected against dementia and autonomic dysfunction. Women and men with PD in our population had different socioeconomic profiles, which may have confounded some gender-associated differences.

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Which features of Parkinson's disease predict earlier exit from the workforce?

Cited by 28 publications

References 10 publications

Working capacity of patients with Parkinson's disease – A systematic review

Working capacity of patients with Parkinson's disease – A systematic review

Clinically meaningful parameters of progression and long-term outcome of Parkinson disease: An international consensus statement

Exploring Gender-Associated Socioeconomic Differences in Parkinson’s Disease

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