This chapter approaches serial literary autofictions as a distinct variant of autofictional writing. While discussions of life writing often focus on male authors, the chapter redresses this imbalance by considering women writers, specifically the works of Dorothy Richardson, Doris Lessing, and Rachel Cusk. The approach is new in exploring the autofictional in serial, literary works, and tracing connections across an author’s oeuvre. Such a focus leads to an extended understanding of autofiction and the autofictional as challenging autobiographical unity and coherence. The chapter distinguishes between different forms of seriality (including series, serial, and serialized life narratives), and argues that serial publications and structures enhance literary and autofictional tendencies in that they draw attention to the complexities of autobiographical representation.