Which method is the most effective for preventing postoperative infection in spinal surgery?

Abstract

Our study suggests that rifamycin application to the surgical area in spinal operations with instrumentation is an effective method to prevent S. aureus infections.

Is implant washing and wound irrigation with rifampicin effective for preventing surgical site infections in lumbar instrumentation?

“…Apart from the retrospective studies, another study carried out using living mammals demonstrated that rifampicin reduced infection (17). However, as is known, the sensitivity of human and animal tissues differs greatly, and may therefore generate misleading results.…”

Preclinical models of vertebral osteomyelitis and associated infections: Current models and recommendations for study design

“…Several rat models of infection have included lumbar vertebral osteomyelitis, implant‐associated infection, isolated discitis and external fixation colonization characterization 33‐35 33,34,36 . Titanium screws inoculated with S. aureus have been used to reproduce an implant associated infection to investigate the efficacy of antibiotic therapies 33,36 .…”

“…33-35 10 2 -10 6 CFU of S. aureus was used as an inoculating agent in infectious models. 33,34,36 Titanium screws inoculated with S. aureus have been used to reproduce an implant associated infection to investigate the efficacy of antibiotic therapies. 33,36 In the study of pin tract bacterial migration, skin flora colonized the titanium pins in the external fixation model.…”

“…33,34,36 Titanium screws inoculated with S. aureus have been used to reproduce an implant associated infection to investigate the efficacy of antibiotic therapies. 33,36 In the study of pin tract bacterial migration, skin flora colonized the titanium pins in the external fixation model. 35 These studies used in vivo monitoring of bioluminescent bacteria, histological evaluation, bacterial cultures, biofilm analysis and postmortem radiographic imaging.…”

Safety of Staphylococcus aureus four-antigen and three-antigen vaccines in healthy adults: A meta-analysis of randomized controlled trials

“…Staphylococcus aureus is a leading cause of infection-related morbidity and mortality [1][2][3][4] and the most common cause of postoperative infection. [5][6][7] Erythromycin, penicillin, gentamicin, and vancomycin are typically used for the treatment of S. aureus infection. However, due to the abuse of antibiotics, new multidrug-resistant strains have emerged, thus hindering the management of S. aureus.…”