Which MRI sequence of the spine best reveals bone-marrow metastases of neuroblastoma?

Meyer, James S.; Siegel, Marilyn J.; Farooqui, Saleem; Jaramillo, Diego; Fletcher, Barry D.; Hoffer, Fredric A.

doi:10.1007/s00247-005-1470-2

Cited by 42 publications

(32 citation statements)

References 18 publications

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“…The higher water content of hematopoietic marrow results in a higher SI on images obtained with a water-sensitive MR sequence. The SI of red marrow approximates that of muscle and is less than that of cerebrospinal fluid on short tau inversionrecovery MR images (10). Although there are no absolute values, a marrow with very low SI on T1-weighted images ( Fig 7) and increased SI on water-sensitive images is suspicious for marrow disease.…”

Section: Figurementioning

confidence: 95%

“…Owing to the exquisite sensitivity to fat of MR imaging, marrow SI reflects not only the fat in the yellow marrow but also the fat in the red marrow. For this reason, on T1-weighted images the SI of normal hematopoietic marrow is similar to or higher than that of muscle ( Fig 3) and is usually higher than the SI of marrow infiltrated by dis-ease (10). In addition, this detection of fat results in an apparent earlier marrow conversion, on the basis of SI on T1-weighted images, than is actually occurring histologically.…”

Section: Figurementioning

confidence: 95%

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MR Imaging Insights into Skeletal Maturation: What Is Normal?

Laor¹,

Jaramillo²

2009

Radiology

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237

130

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Skeletal growth and maturation in children is a dynamic process that can be documented with magnetic resonance (MR) imaging. There are predictable normal developmental changes that must be differentiated from pathologic processes. This review discusses the histologic structure and MR imaging appearance of normal development-related changes of the musculoskeletal system in children, including those that may be mistaken for abnormalities.

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Section: Figurementioning

confidence: 95%

Section: Figurementioning

confidence: 95%

MR Imaging Insights into Skeletal Maturation: What Is Normal?

Laor¹,

Jaramillo²

2009

Radiology

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237

130

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“…MRI is better for paraspinal lesions and is essential when assessing intraforaminal extension of the tumour and its potential for cord compression [2]. MRI is also superior to CT for characterising epidural extension, leptomeningeal disease and for the detection of bone marrow metastases [16]. However, many district hospitals may not have the facilities for paediatric MRI, particularly in the age group prevalent for neuroblastoma, in whom general anaesthesia is often required.…”

Section: Extra-abdominal Presentations Of Neuroblastomamentioning

confidence: 99%

Clinical presentations and imaging findings of neuroblastoma beyond abdominal mass and a review of imaging algorithm

Chu¹,

Rasalkar²,

Hu³

et al. 2011

BJR

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Neuroblastoma is one of the most common malignant neoplasms in childhood. The most common clinical presentation of this tumour is abdominal mass. However, affected children may have various clinical presentations as a result of disseminated metastatic disease or associated paraneoplastic syndromes at the time of diagnosis. In this article we have outlined the imaging findings in seven patients with "extra-abdominal" presentation of neuroblastoma and the pitfalls in making the correct diagnosis. The purpose of this pictorial review is to alert the general radiologist to the possible presentations of this common childhood malignancy to derive early detection and diagnosis.

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“…Of the 31 studies, 8 studies formulated a definition of bone metastases [8,[18][19][20][21][22][23][24], 13 of bone marrow metastases [25][26][27][28][29][30][31][32][33][34][35][36][37] and 10 defined both types of metastases [38][39][40][41][42][43][44][45][46][47] (Table 2). The included studies used different imaging methods to detect bone or bone marrow metastases (per study often more than one imaging method was used).…”

Section: Characteristics Of Included Studies Objective 1: Definitionsmentioning

confidence: 99%

A Systematic Literature Review of Imaging Definitions for Detection of Bone and Bone Marrow Metastases in Neuroblastoma Patients

Bleeker¹,

Heijkoop²,

Dalen³

et al. 2015

J Bone Marrow Res

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Objective: The presence of bone and bone marrow (BM) metastases in neuroblastoma patients are independent adverse prognostic factors, so precise and consistent definitions of both categories on imaging are important. The objectives of this systematic review were to identify all definitions reported for detection of bone and bone marrow metastases on imaging in neuroblastoma to determine diagnostic accuracies of the most frequently used definitions for detection of bone and/or BM metastases on each imaging technique. Methods: We searched MEDLINE/PubMed (1945 to April 2013) and EMBASE/Ovid (1980 to April 2013). Full-text original studies were included if they reported definitions of bone and/or BM metastases on diagnostic imaging of children with suspected metastatic neuroblastoma. As reference standard for bone metastases bone scintigraphy was used and for bone marrow metastases bone marrow biopsies/aspirates. Methodological quality was assessed. Results: Of 403 identified studies (plus one relevant reference), 131 were assessed in full-text and 31 finally included, 23 described BM metastases and 18 bone metastases. No uniform definitions of bone and bone marrow metastases were reported for each imaging method. On MIBG scintigraphy bone metastases were mostly defined as "focal" and BM metastases as "diffuse" and on MRI both definitions were used for BM metastases. The diagnostic accuracy of different diagnostic methods to detect bone (reference test bone scintigraphy) or BM (reference test bone marrow biopsies/ trephines) metastases varied widely. Conclusion: No uniform definitions of bone and bone marrow metastases were reported for each imaging method and concerning the diagnostic accuracy no general conclusions could be drawn.

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Which MRI sequence of the spine best reveals bone-marrow metastases of neuroblastoma?

Abstract: The combination of non-contrast-enhanced T1W and GAD sequences can be used to determine the presence of spinal metastases in children with neuroblastoma, particularly those children who are 1 year and older.

Cited by 42 publications

References 18 publications

MR Imaging Insights into Skeletal Maturation: What Is Normal?

MR Imaging Insights into Skeletal Maturation: What Is Normal?

Clinical presentations and imaging findings of neuroblastoma beyond abdominal mass and a review of imaging algorithm

A Systematic Literature Review of Imaging Definitions for Detection of Bone and Bone Marrow Metastases in Neuroblastoma Patients

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