2013
DOI: 10.1007/s10549-012-2360-6
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Which nomogram is best for predicting non-sentinel lymph node metastasis in breast cancer patients? A meta-analysis

Abstract: To present a systematic [corrected] review and meta-analysis to evaluate the nomograms developed to predict non-sentinel lymph node (NSLN) metastasis in breast cancer patients. We focused on the six nomograms (Cambridge, MSKCC, Mayo, MDA, Tenon, and Stanford) that are the most widely validated. The AUCs were converted to odds ratios for the meta-analysis. In total, the Cambridge, Mayo, MDA, MSKCC, Stanford, and Tenon models were validated in 2,156, 2,431, 843, 8,143, 3,700, and 3,648 patients, respectively. Th… Show more

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Cited by 59 publications
(48 citation statements)
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“…Some of them did not find it trustworthy particularly for SLNs with micrometastatic involvement, while others have proposed a different procedure for improving predictive accuracy (11,33). Given that the patients presented with a high frequency of micrometastasis, the predictive ability of non-SLN involvement of the Tenon and Stanford nomograms is the most important in this regard (14,34). In two studies, the MSKCC nomogram did not prove to be reliable for identifying non-SLN metastasis in patients with micrometastasis-positive SLNs, with an area under the ROC curve of 54% and 59%, respectively (11,34).…”
Section: Resultsmentioning
confidence: 99%
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“…Some of them did not find it trustworthy particularly for SLNs with micrometastatic involvement, while others have proposed a different procedure for improving predictive accuracy (11,33). Given that the patients presented with a high frequency of micrometastasis, the predictive ability of non-SLN involvement of the Tenon and Stanford nomograms is the most important in this regard (14,34). In two studies, the MSKCC nomogram did not prove to be reliable for identifying non-SLN metastasis in patients with micrometastasis-positive SLNs, with an area under the ROC curve of 54% and 59%, respectively (11,34).…”
Section: Resultsmentioning
confidence: 99%
“…However, the Cambridge model and a novel Turkish formula seem to be uninfluenced by SLN micrometastasis and non-SLN positivity Table 6. Analysis of the impact of lymphovascular invasion on sentinel lymph node metastasis (literature review) (9,(15)(16)(17)(18)(19) rates and have an area under the ROC curve of over 80% each, and thus deserve further validation in prospective trials (13,14,35). Age, menopausal status, HT, HG, size of the tumour, lymphatic and blood vessel invasion, and hormone receptor status are previously studied factors.…”
Section: Resultsmentioning
confidence: 99%
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“…Sentinel lymph node biopsy (SLNB) has successfully replaced ALND for evaluation of the axilla in breast cancer patients with clinically negative axilla (Kell et al, 2010). However, ALND performed in SLNBpositive patients demonstrated the absence of metastasis in 22-71% of the non-SLNs (Zhu et al, 2013).…”
Section: Introductionmentioning
confidence: 99%
“…This nomogram has been the most validated one using different data sets. 8 We investigated whether the MSKCC nomogram could precisely predict non-SN metastasis in our data set. The results are shown in Table 7.…”
Section: Evaluation Of the Memorial Sloan Kettering Cancer Center (Msmentioning
confidence: 99%