Which one of LDL-C /HDL-C ratio and non-HDL-C can better predict the severity of coronary artery disease in STEMI patients

Abstract

Background The increase of low-density lipoprotein cholesterol (LDL-C) is widely accepted as an important factor in the occurrence of atherosclerosis. In recent years, the guidelines have recommended non-high density lipoprotein cholesterol (non-HDL-C) as a secondary target for lipid-lowering therapy. But even as research on the relationship between LDL-C/HDL-C and atherosclerosis increases, it is still undetermined which index is most closely related to the severity of acute ST-segment elevation myocardial infarction (STEMI). Methods 901 patients who received coronary angiography due to chest pain were selected. Among them, 772 patients with STEMI represented the test group, and 129 patients with basically normal coronary angiography represented the control group. Researchers measured fasting blood lipids and other indicators after admission, and determined the severity of coronary artery disease using the Gensini score. Results LDL-C/HDL-C and non-HDL-C indexes were statistically different between the two patient groups. In the test group, total cholesterol (TC), triglycerides (TG), LDL-C, high density lipoprotein cholesterol (HDL-C), non-HDL-C, arteriosclerosis index (AI), and LDL-C/HDL-C all correlated with the patients' Gensini score. After applying the stepwise method of multiple linear regression analysis (R2 = 0.423, β = 0.518, p < 0.05), LDL-C/HDL-C had the most correlation with the patient's Gensini score. ROC curve analysis suggested that LDL-C/HDL-C can predict whether patients with chest pain are STEMI (AUC: 0.880, 95% Cl: 0.847–0.912, p < 0.05). When cutoff value is 2.15, sensitivity is 0.845, and specificity is 0.202, LDL-C/HDL-C is an effective indicator for predicting whether patients with chest pain have STEMI. Conclusion Compared to ratios of non-HDL-C and LDL-C, the LDL-C/HDL-C ratio in patients with STEMI is more correlated with the severity of coronary artery disease. It can better evaluate the severity of coronary artery disease and better predict whether patients with chest pain are STEMI.

Preclinical Investigations on Anti-fibrotic Potential of Long-Term Oral Therapy of Sodium Astragalosidate in Animal Models of Cardiac and Renal Fibrosis

“…In our study, to further provide the availability of SA and investigate the anti-fibrotic effects of long-term oral administration of SA, db/db mice presenting diabetic renal fibrosis were used, increasing the duration of oral administration (8 weeks) as well as using multiple dosing concentrations. Our study indicated that oral administration of SA has no significant hypoglycemic or body weight-lowering effects in db/db mice, which is consistent with other experimental results . Interestingly, evidence accumulated from many reports showed that dyslipidemia, specifically cholesterol-rich lipoproteins, plays a key role in the progression of kidney disease in patients with diabetes.…”

“…Our study indicated that oral administration of SA has no significant hypoglycemic or body weight-lowering effects in db/db mice, which is consistent with other experimental results. 30 Interestingly, evidence accumulated from many reports showed that dyslipidemia, specifically cholesterol-rich lipoproteins, plays a key role in the progression of kidney disease in patients with diabetes. TC, TG, LDL, and HDL are important indicators of blood lipid analysis.…”

Genetic Determinants of Atherogenic Indexes

“…Lipids levels and lipid indexes have been of some help because of their association to cardiovascular risk. For example, LDL-C, TG, and HDL-C are strongly correlated to coronary heart disease (CHD) although their underlying genetics has not been fully characterized [9]. A genetic profile that may aid in the identification of dyslipidemia, and CVD or its predisposition could propel earlier diagnosis and interventions.…”

“…The atherogenic index of plasma (AIP=log TG/HDL-C) can accurately predict hypertension, metabolic syndrome, and ischemic stroke even when HDL-C and TG levels seem normal or when isolated values of TG or HDLC-C cannot assess this risk [14,15]. The direct measurement of HDL-C and LDL-C has shown bias in assessing cardiovascular health (16) but their ratio i.e., the CI2 (LDL-C/HDL-C, CI2), although less cited, has been confirmed as a better predictor of cardiovascular risk [9,16,17]. Hence, there is an apparent, but not as frequently acknowledged, value of AIP and CI2 indexes to identify cardiovascular risk.…”

Metabolic disturbances in sedentary and active Polish male students with normal body mass index and waist circumference

“…It evaluated circulating lipoproteins, glucose, insulin and the index of insulin resistance (HOMA-IR) in male students of Józef Piłsudski University of Physical Education with normal BMI and WC in the context of their physical activity. At the same time calculated TC/HDL, LDL/HDL and TG/HDL ratio which are used to predict development of diabetes, coronary heart disease and cardiovascular mortality [11,21]. According to many researchers, they can become a valuable tool in the field of primary and secondary prevention strategies [23,26].…”