2022
DOI: 10.5114/aoms/147435
|View full text |Cite
|
Sign up to set email alerts
|

Which patients at risk of cardiovascular disease might benefit the most from inclisiran? – The expert opinion of the Polish experts. The compromise between EBM and possibilities in healthcare.

Abstract: It is the statement of the Polish Experts on the group of patients that might benefit the most from inclisiran. We indicated the fastest way to have inclisiran available for the polish patients, with the necessary changes of the existing drug program for PCSK9 inhibitors (B-101), explaining why it is the optimal way, and why, taking into account available EBM data (the ORION program), inclisiran should be added to this program. We also present some perspective on the future necessary changes in the availabilit… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
10
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
8

Relationship

3
5

Authors

Journals

citations
Cited by 12 publications
(10 citation statements)
references
References 30 publications
0
10
0
Order By: Relevance
“…In 2022, we have so many effective drugs (including new agents close on the horizon), and effective and scientifically confirmed approaches to treatment. Therefore, we simply cannot afford to lose our patients due to our own ineffectiveness and therapeutic inertia [ 50 ]. So, starting from now #ThinkUpfront!…”
mentioning
confidence: 99%
“…In 2022, we have so many effective drugs (including new agents close on the horizon), and effective and scientifically confirmed approaches to treatment. Therefore, we simply cannot afford to lose our patients due to our own ineffectiveness and therapeutic inertia [ 50 ]. So, starting from now #ThinkUpfront!…”
mentioning
confidence: 99%
“…Hyperlipidemia may also be a secondary condition due to underlying diseases such as uncontrolled diabetes mellitus, chronic kidney disease, Cushing syndrome, polycystic ovarian syndrome, and hypothyroidism [ 10 ]. Furthermore, drugs (e.g., glucocorticoids, beta blockers, atypical antipsychotics) and dietary factors—mainly alcohol—may also contribute to the development of dyslipidemia [ 11 ].…”
Section: Causes Of Hyperlipidemiamentioning
confidence: 99%
“…Moreover, alcohol consumption increases the risk of statin intolerance by 22% [ 22 ]. This is important because hypercholesterolemia is the most common cardiovascular risk factor in Poland, affecting as many as 21 million people [ 23 ].…”
Section: Definition Of the Alcohol Unit And Clinical Recommendations ...mentioning
confidence: 99%