Whipple’s disease orbitopathy: case report and review of literature

Sampaio, Filipa; Moreira, Jorge; Jordão, Sofia; Vieira, Bruna; Pereira, Sara; Carvalho, Rui

doi:10.1080/01676830.2020.1820044

Cited by 4 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our case report describes a patient who had three classical manifestations (weight loss, diarrhea, and abdominal pain), with skin hyperpigmentation, and she was diagnosed with Whipple’s disease during the study to determine the etiology of the clinical condition. In this case, there was no involvement of other organs, but there are cases in which there is, and that allows us to think about the diagnosis more urgently, namely, when there are manifestations such as seizures, gait changes, dementia, psychiatric disorders, arthralgias or arthritis, or ocular, pulmonary, cardiac, or hematologic involvement [ 2 , 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Whipple’s Disease: A Case Report

Batista¹,

Santos²,

Silva³

et al. 2023

Cureus

View full text Add to dashboard Cite

Whipple’s disease (WD) is caused by Tropheryma whipplei , frequently found in lamina propria’s macrophages in the small intestine. It is a rare and chronic systemic infection, and the principal clinical manifestations are diarrhea, weight loss, abdominal pain, and arthralgia. The diagnosis is difficult mainly because of its rarity and should be considered in patients with arthralgias, diarrhea, abdominal pain, and weight loss after more common conditions have been excluded. The laboratory diagnosis is established by a duodenal biopsy. The treatment involves 14 days of intravenous antibiotics with good penetration in the cerebrospinal fluid (i.e., ceftriaxone) and one-year treatment with oral co-trimoxazole. Early diagnosis and proper treatment are crucial because it improves the prognosis. We report the case of a 58-year-old female with skin hyperpigmentation, loss of appetite and weight (16% of body weight in three months), nausea, upper abdominal pain, and diarrhea. Esophagogastroduodenoscopy and colonoscopy were performed to obtain biopsy samples, which, together with laboratory tests and microbiological studies, led to a diagnosis of Whipple’s disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Whipple’s Disease: A Case Report

Batista¹,

Santos²,

Silva³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…One of the least common manifestations of Whipple's disease is within the orbital tissues. Sampaio et al [52] recently presented and reviewed all the seven reported cases of orbital Whipple's disease in the literature. Orbital Whipple's disease presents with symptoms and signs similar to that of orbital inflammatory syndrome: pain, diplopia, vision changes, conjunctival injection, periorbital oedema, chemosis, proptosis and extraocular motility limitations in keeping with myositis.…”

Section: Orbitalmentioning

confidence: 99%

Ophthalmic manifestations of Whipple's disease

Rasool

2023

Current Opinion in Ophthalmology

View full text Add to dashboard Cite

Purpose of review Whipple's disease is an infectious cause of uveitis that may present with nonspecific findings of intraocular inflammation, which can precede the development of neurologic symptoms and signs. Whipple's disease, then, may evade consideration in the differential diagnosis for uveitis. Recent findings Molecular tests can be helpful in identifying the presence of Tropheryma whipplei from ocular specimens. The application of metagenomic sequencing for ocular specimens is promising, as it offers the opportunity to identify the pathogen when suspicion for an intraocular infection is high. Whipple's disease demonstrates the ability to abrogate the host immune response, which gives some insight into its pathogenesis. Summary Whipple's disease should be suspected in patients who have uveitis refractory to anti-inflammatory therapy. Knowledge of this important pathogen can help direct the timely implementation of diagnostic testing.

show abstract

Lyme disease and Whipple’s disease: a comprehensive review for the rheumatologist

Giardini,

Neves,

Pereira

et al. 2024

Adv Rheumatol

View full text Add to dashboard Cite

Despite their rarity, Lyme disease and Whipple’s disease are of significant importance in rheumatology, as both can manifest as chronic arthritis, presenting challenges in the differential diagnosis of inflammatory arthropathies. In Lyme disease, arthritis typically emerges as a late manifestation, usually occurring six months after the onset of erythema migrans. The predominant presentation involves mono- or oligoarthritis of large joints, with a chronic or remitting-recurrent course. Even with appropriate antimicrobial treatment, arthritis may persist due to inadequate immunological control triggered by the disease. In contrast, Whipple’s disease may present with a migratory and intermittent seronegative poly- or oligoarthritis of large joints, preceding classic gastrointestinal symptoms by several years. Both disorders, particularly Whipple’s disease, can be misdiagnosed as more common autoimmune rheumatic conditions such as rheumatoid arthritis and spondyloarthritis. Epidemiology is crucial in suspecting and diagnosing Lyme disease, as the condition is transmitted by ticks prevalent in specific areas of the United States, Europe, and Asia. On the contrary, the causative agent of Whipple’s disease is widespread in the environment, yet invasive disease is rare and likely dependent on host genetic factors. In addition to erythema migrans in Lyme disease and gastrointestinal manifestations in Whipple’s disease, neurological and cardiac involvement can further complicate the course of both. This article offers a comprehensive review of the epidemiological, pathophysiological, clinical, and therapeutic aspects of both diseases.

show abstract

Whipple’s disease orbitopathy: case report and review of literature

Cited by 4 publications

References 22 publications

Whipple’s Disease: A Case Report

Whipple’s Disease: A Case Report

Ophthalmic manifestations of Whipple's disease

Lyme disease and Whipple’s disease: a comprehensive review for the rheumatologist

Contact Info

Product

Resources

About