Notwithstanding the fact that the problem of drill string buckling (Eulerian instability) inside the cylindrical cavity of an inclined bore-hole attracts attention of many specialists, it is far from completion. This peculiarity can be explained by the complexity of its mathematic model which is described by singularly perturbed equations. Their solutions (eigen modes) have the shapes of boundary effects or buckles (harmonic wavelets) localized in zones of the bore-hole that are not specified in advance. Therefore, the problem should be stated in the domain of entire length of the drill string or in some separated part including an expected zone of its buckling. In the paper, a mathematic model for computer analysis of incipient buckling of a drill string in cylindrical channel of an inclined bore-hole is elaborated. The constitutive equation is deduced with allowance made for action of gravity, contact, and friction forces. Computer simulation of the drill string buckling is performed for different values of the bore-hole inclination angle, its length, friction coefficient, and clearance. The eigen values (critical loads) are found and modes of stability loss are constructed. The numerical results for the case when the inclination angle equals friction angle coincide with ones obtained analytically.