White blood cell count and eosinopenia as valuable tools for the diagnosis of bacterial infections in the ED

Lavoignet, C.E.; Borgne, Pierrick Le; Chabrier, Sylvie; Bidoire, Joffrey; Slimani, Hakim; Chevrolet-Lavoignet, Julia; Lefèbvre, François; Jebri, Rania; Sengler, Luc

doi:10.1007/s10096-019-03583-2

Cited by 47 publications

(38 citation statements)

References 37 publications

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“…Adam et al reported that in patients with acute exacerbations of chronic obstructive pulmonary disease, eosinopenia increases the risk of treatment failure and in-hospital mortality [8]. Other studies have also demonstrated eosinopenia in late stage bacterial pneumonias, as well as COVID-19 [9]. This is consistent with our results of eosinopenia in more severely affected patients.…”

Section: Discussionsupporting

confidence: 92%

Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience

Sun

Dong

Wang

et al. 2020

Journal of Autoimmunity

209

185

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Section: Discussionsupporting

confidence: 92%

Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience

Sun

Dong

Wang

et al. 2020

Journal of Autoimmunity

209

185

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“…In addition, leukocyte counts are still a suitable parameter for diagnosing infection. However, the relationship between the prognosis of infection and leukocyte has rarely described [21]. In our study, the routine blood tests showed evidence of elevated leukocyte count in all the patients except for 2; one complicated with acute lymphocytic leukemia, the other with T-cell lymphoma.…”

Section: Discussionsupporting

confidence: 41%

Clinical Characteristics and Prognosis of Adult Orbital Cellulitis in a Tertiary General Hospital

Yao

Ding

Zhao

et al. 2020

Preprint

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Background: Adult orbital cellulitis (OC) occurs relatively rarely, and comprehensive studies that retrospectively evaluate OC are lacking. Here we aimed to examine the clinical characteristics and prognosis of OC in a tertiary general hospital. Methods: Between October 2010 and May 2019, patients presenting with clinical symptoms of OC in a tertiary general hospital were analyzed in this retrospective study. Twenty-six cases were identified for a detailed review. In these cases, 16 males and 10 females were diagnosed with orbital cellulitis by clinical characteristics and multimodal examinations. We divided patients into three groups: (1) patients secondary to rhinosinusitis, (2) patients secondary to endogenous infection(s) without endophthalmitis, and (3) patients secondary to endophthalmitis. For each group, the age, gender, eye type, combined systemic diseases, clinical presentation, leukocyte count, blood culture, diagnostic imaging, therapeutic methods, length of stay, time of post-operation, and patient prognosis were analyzed in detail. Results: There were no significant differences regarding age, gender, preoperative leukocyte count, exophthalmia, blood culture, treatment, or visual changes within the three groups (P>0.05). There were significant differences, however, in postoperative leukocyte count and ophthalmoplegia between the three groups (P<0.05). The preoperative and postoperative logarithm of the minimum resolution angle scored by the best-corrected visual acuity (LogMAR BCVA) of group 3 were statistically significant compared to group 1 and group 2 (P<0.05). Conclusion: We confirmed that the prognosis of OC patients combined with systemic diseases was poor; the visual outcome of OC secondary to endophthalmitis was more serious than that, secondary to sinusitis or endogenous infection without endophthalmitis. The level of leukocytes may indicate the condition of the disease.

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“…Third, as in the previous SARS-CoV outbreaks, (Zahariadis, et al, 2006), COVID-19 mortality and serious morbidity is highly associated with pneumococcal and haemophilus co-infections, as well as other, secondary infections (Xia, et al, 2020;Wang, et al, 2020). Such patients invariably have severe eosinopenia (Li, et al, 2020;Zhang, et al, 2020), which is an accurate indicator of systemic bacterial infection (Lavoignet, et al, 2019). Below 15/mm3, eosinopenia can differentiate bacterial from viral infection with reasonable accuracy (Debray, et al, 2019).…”

mentioning

confidence: 74%

Why Infants Rarely Die of COVID-19 and Morbidity and Mortality Rates Vary by Location: Pneumococcal and Hib Vaccinations as Possible Means to Mitigate Future Pandemics

Root‐Bernstein¹

2020

Preprint

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Two conundrums have puzzled COVID-19 investigators: 1) morbidity and mortality is rare among Infants and young children and 2) rates of morbidity and mortality exhibit very large variances across nations, locals and even within cities. These differences correlate with rates of Haemophilus influenzae type B (Hib) and pneumococcal vaccination, which are almost universal among infants and vary widely by geography among adults and the elderly. The higher the rate of vaccination, the lower the COVID-19 morbidity and mortality. Vaccination rates with other vaccines, including BCG and poliovirus, do not correlate with COVID-19 risks.

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White blood cell count and eosinopenia as valuable tools for the diagnosis of bacterial infections in the ED

Cited by 47 publications

References 37 publications

Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience

Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience

Clinical Characteristics and Prognosis of Adult Orbital Cellulitis in a Tertiary General Hospital

Why Infants Rarely Die of COVID-19 and Morbidity and Mortality Rates Vary by Location: Pneumococcal and Hib Vaccinations as Possible Means to Mitigate Future Pandemics

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