White blood cell count is associated with carotid and femoral atherosclerosis

Ortega, Emilio; Gilabert, Rosa; Núñez, Isabel Testón; Cofán, Montserrat; Sala‐Vila, Aleix; Groot, Eric de; Ros, Emili

doi:10.1016/j.atherosclerosis.2011.12.038

Cited by 51 publications

(56 citation statements)

References 42 publications

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“…Previous studies have found that the leukocyte count, a universally acceptable marker of chronic lowgrade inflammation, is related to carotid plaque formation 32,33) . An increased level of CRP also reflects low-grade inflammation and is associated with carotid atherosclerosis, although there is a gender difference 34,35) .…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome and Early Carotid Atherosclerosis in the Elderly

Jung

Kwon

Han

et al. 2014

JAT

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Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome and Early Carotid Atherosclerosis in the Elderly

Jung

Kwon

Han

et al. 2014

JAT

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“…Results showed that pod and seed extract did not cause statistically significant difference (P>0.05) in the total WBC count of Group C and D rats (10,600±406.4 mm 3 and 9,800±202.6 mm 3 ) compared with control group A rats (10,900±190.9 mm 3 ). However, clomiphene citrate caused significant reduction in total WBC (P<0.05) of Group B rats (7,400±60.7 mm 3 ) compared to control group, Group C and D. There was statistically significant reduction (P < 0.05) in neutrophil count of Group C rats (25.0±1.0 %) compared to control group A (38.0±2.0 %), Group B (33.0±1.0 %), and Group D (34.0±2.0 %).…”

Section: Resultsmentioning

confidence: 83%

“…The total number of WBC in the circulation is given as the peripheral WBC count and proportion of the total number of WBC represented by differentiated granulocytes (neutrophils, eosinophils and basophils), lymphocytes and monocytes is given as the differential WBC count, and are biomarkers for predicting acute infection, tissue damage, inflammation, diabetes, atherosclerosis and mortality [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effects of Tetrapleura tetraptera Extract and Clomiphene Citrate to Determine Influence of Reproductive Hormones and Estrous Cycle on Leukocyte Counts: Novel Evidence for a Potential Developmental Link Between Luteinizing Hormone and MID Cells

Onuka¹,

Okechukwu²,

Maxine³

et al. 2017

HTIJ

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Estrous cycle influences circulating leukocyte count via reproductive hormones. Tetrapleura tetraptera extract has been shown to cause an increase in leukocyte count. Our previous work showed that Tetrapleura tetraptera pod extract inhibited LH and estrogen around ovulation stage. Therefore, the present study evaluated the effects of Tetrapleura tetraptera extracts and clomiphene citrate on leukocyte counts in order to determine whether the varying reproductive hormones secreted in both extracts and drug, and estrous cycle caused alteration in leukocyte counts.Twenty eight adult female rats were selectively divided into 4 groups (n = 7) according to their estrous phases. The group A served as control. Group B rats were administered 1 mg/kg of clomiphene citrate daily. Group C and D rats were administered 50 and 200 mg/kg of seed and pod extracts daily. Results showed that total WBC count was significantly reduced (P<0.05) in proestrus Group B. Total WBC, and lymphocyte counts remained unchanged. Neutrophil count was significantly reduced (P<0.05) in estrus Group C. The MID cell count was significantly reduced in estrus Group C and D. The total WBC counts, lymphocyte count, serum FSH, estrogen and glucocorticoid levels were not statistically significant. Serum LH was significantly high (P < 0.05) in proestrus Group B. Serum LH was significantly low in estrus Group C and D. Results showed that the significant reduction in the neutrophil in Group D is independent of the hormones and estrous cycle but dependent on dose concentration of Tetrapleura tetraptera extract. The significant elevation in MID cell count was associated with significant reduction in LH in Group C and D. However, total leukocyte count and MID cell count were significantly reduced and appeared to be associated with significant elevation in serum LH levels. The present study provides a novel idea of how LH affects MID cell population.

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“…Since a high white blood cell count, which indicates elevated inflammatory activity, is significantly positively associated with atherosclerosis [4], height may be inversely associated with this disease. In fact, our previous study of Japanese men revealed an inverse association between height and carotid atherosclerosis in overweight (BMI ≥ 25 kg/m 2 ), but not non-overweight (BMI < 25 kg/m 2 ) subjects [2].…”

Section: Discussionmentioning

confidence: 99%

“…Our previous study of Japanese men revealed an inverse association between height and carotid atherosclerosis among overweight subjects, but not in those who were not overweight [2]. Atherosclerosis is known to be a chronic inflammatory disease [3], and a higher white blood cell count has also been identified as a marker of systemic inflammatory activity that is known to be associated with atherosclerosis [4]. In connection with these phenomena, we also reported that short stature is associated with inflammatory disadvantages since high white blood cell count is inversely associated with height in subjects with a body mass index (BMI) ≥ 23 kg/m 2 but not in those with a BMI < 23 kg/m 2 [5].…”

Section: Introductionmentioning

confidence: 97%

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2018

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Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a crosssectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (≥ 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = −0.22, p = 0.019 for subjects with high hemoglobin, and β = −0.01, p = 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21, p = 0.037 and r = 0.40, p =< 0.001), but not in subjects with low hemoglobin (r = 0.04, p = 0.710 and r = 0.06, p = 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and circulating CD34-positive cells. These results indicate that subjects with a short stature activate vascular remodeling to a much greater extent than subjects with a tall stature.

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White blood cell count is associated with carotid and femoral atherosclerosis

Cited by 51 publications

References 42 publications

Metabolic Syndrome and Early Carotid Atherosclerosis in the Elderly

Metabolic Syndrome and Early Carotid Atherosclerosis in the Elderly

Evaluation of the Effects of Tetrapleura tetraptera Extract and Clomiphene Citrate to Determine Influence of Reproductive Hormones and Estrous Cycle on Leukocyte Counts: Novel Evidence for a Potential Developmental Link Between Luteinizing Hormone and MID Cells

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