White blood cell count to mean platelet volume ratio: A novel and promising prognostic marker for ST-segment elevation myocardial infarction

Çiçek, Gökhan; Açi̇kgöz, Sadık Kadri; Yayla, Çağrı; Kundi, Harun; İleri, Mehmet

doi:10.5603/cj.a2016.0001

Cited by 29 publications

(36 citation statements)

References 26 publications

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“…[16] In another study in which 2603 patients were analysed, male sex was found to be 81.8%. [12] According to the results obtained in our study, the male sex constituted the major group, and it was found to be similar to the literature. e relationship between myocardial infarction and inflammation has been known for over 80 years [3].…”

Section: Discussionsupporting

confidence: 90%

“…According to the literature data, it is suggested that many parameters can be used in the evaluation of hemogram for short-and long-term evaluation of mortality of acute myocardial infarction patients. Clinical and meta-analysis studies are available that indicate that NLR and WBC may be independent factors in determining mortality [9,10,12]. In most of these studies, the number of cases is limited, and this is stated as a limiting factor.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that atherosclerotic plaques with intense inflammation increase the susceptibility to acute coronary syndrome [17]. Clinical and meta-analysis studies are available that indicate that NLR and WBC may be independent factors in determining mortality [9,10,12]. A study by Zazula et al investigated the diagnostic importance of NLR.…”

Section: Discussionmentioning

confidence: 99%

“…In patients with acute myocardial infarction, high WBC values are associated with poor epicardial and myocardial perfusion and poor clinical outcome [24]. In the study conducted by Çiçek and his colleagues, along with showing the relationship of increased WBC values and higher mortality, they revealed 14,400 (57.8% sensitivity; 90.3% specificity) as cutoff value [12]. Even though there are studies examining the relationship of WBC and mortality, there are limited data on cutoff values.…”

Section: Discussionmentioning

confidence: 99%

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The Effectiveness of Neutrophil-Lymphocyte Ratio in Predicting in-Hospital Mortality in Non-ST-Elevation Myocardial Infarction

Avcı

Dönmez

et al. 2020

Emergency Medicine International

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Background. Myocardial infarction is the most common cause of death all over the world. There are many studies in predicting mortality. The aim of this study was to determine the effectiveness of hematologic parameters measured at the moment of admission to the emergency room in predicting in-hospital mortality and to determine cutoff values of strongly predictive values. Methods. A total of 681 patients over 18 years of age, whose date could be obtained, were included in the study. From the hemogram parameters, white blood cells (WBC), red cell distribution width (RDW), mean platelet volume (MPV), and neutrophils-to-lymphocytes ratio (NLR) values were determined and recorded. CK-MB and high-sensitive troponin T values were recorded as cardiac markers. For statistical analysis, “SPSS for Windows version 21” package program was used. Results. 62.6% (n = 426) of the patients were male, and 37.4% (n = 255) of the patients were female. The NLR was found to be the strongest predictor (area under the curve (AUC), 0.783, SD = 0.052, 95% confidence interval (CI)). It was found that the WBC value came in the second place after NLR as a strong predictor of mortality (AUC, 0.702, SD = 0.075, 95% CI). Conclusion. According to the hemogram results which were acquired with a simple and cheap method, we found that WBC and especially NLR values obtained with a simple method can be used as powerful predictors.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Effectiveness of Neutrophil-Lymphocyte Ratio in Predicting in-Hospital Mortality in Non-ST-Elevation Myocardial Infarction

Avcı

Dönmez

et al. 2020

Emergency Medicine International

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“…Nunez reported that WCC independently increased the risk of death for 30 days and 1 year in patients with STEMI 24. Çiçek et al examined that the incidence of MACE in atients with STEMI with elevated WCC increased significantly during the hospitalisation 25…”

Section: Discussionmentioning

confidence: 99%

Predicting value of white cell count and total bilirubin on clinical outcomes in patients with ST-elevation myocardial infarction following percutaneous coronary intervention: a cohort study

Tuxun

Zhao²,

Xiang

et al. 2020

BMJ Open

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ObjectivesA combined equation based on white cell count (WCC) and total bilirubin (TB) was assessed for its ability to predict adverse clinical outcomes in patients with acute ST-segment elevation myocardial infarction (STEMI) with primary percutaneous coronary intervention (PCI).DesignA single-centre, prospective cohort study.SettingThe First Affiliated Hospital of Xinjiang Medical University.MethodA total of 615 patients with STEMI postprimary PCI were enrolled. WCC and TB were collected at admission. Logistic regression was used to determine the combined equation. The primary endpoints were in-hospital mortality and major adverse cardiovascular events (MACE), which composed of cardiac death, cardiac shock, malignant arrhythmia (ventricular tachycardia, ventricular fibrillation), severe cardiac insufficiency, non-fatal myocardial infarction, angina pectoris readmission, severe cardiac insufficiency (cardiac III–IV level), stent restenosis and target vessels revascularisation during the hospitalisation and 36 months follow-up period.Result77 patients occurred in MACE during the hospitalisation (17 in-hospital mortality). WCC and TB were taken as an independent variables to make a category of logistic regression analysis of in-hospital MACE, the logistic regression model was: logit (P)=−8.00+0.265 WCC+0.077 TB, the combination of WCC and TB was more valuable on evaluating the in-hospital mortality (area under the curve 0.804, 95% CI 0.678 to 0.929, p<0.001). Multivariate logistic regression analysis showed that combined detection was an independent risk factor for in-hospital MACE (OR 5.85, 95% CI 3.425 to 9.990, p=0.032). During the follow-up period, 172 patients (29.5%) developed MACE. But the combined detection did not predict the long-term clinical outcome.ConclusionThe combination of WCC and TB is an independent predictor for in-hospital outcomes in patients with STEMI than single detection.

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Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

Li-yin

Pan

Rong-lian

et al. 2019

Clinical Laboratory Analysis

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Background Histological chorioamnionitis (HCA) is one of the leading causes of spontaneous preterm birth, thus, to identify novel biomarkers for the early diagnosis of HCA is in a great need. Objective To investigate the diagnostic value of maternal peripheral blood platelet‐to‐white blood cell ratio (PLT/WBC) and platelet (PLT) counts in HCA‐related preterm birth. Methods A total of 400 patients with preterm birth were enrolled in this study: non‐HCA group (n = 193) and HCA group (n = 207), and 87 full‐term pregnancies were enrolled as the control. The peripheral blood of the participators was collected, and the neutrophil count, WBC count, platelet count, and levels of C‐reactive protein (CRP) and procalcitonin were recorded, and the platelet‐to‐white blood cell ratio (PLT/WBC) of the participators was calculated. Receiver operating characteristic (ROC) curve has been drawn to show the sensitivity and specificity of PLT/WBC and PLT count for the diagnosis of HCA‐related spontaneous preterm birth patients. Results The neutrophil count, WBC count, and procalcitonin show no significant differences among the three groups, and the PLT count, PLT/WBC, and CRP (P < 0.05) were significantly increased in HCA group compared with non‐HCA group; moreover, the area under the curve (AUC) of PLT/WBC, PLT, and CRP was 0.744 (95% confidence interval [CI], 0.6966‐0.7922), 0.8095 (95% CI, 0.7676‐0.8514), and 0.5730 (95% CI, 0.5173‐0.6287), respectively. Conclusion Platelet count and PLT/WBC may become a potential biomarker of HCA‐related spontaneous preterm birth.

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White blood cell count to mean platelet volume ratio: A novel and promising prognostic marker for ST-segment elevation myocardial infarction

Cited by 29 publications

References 26 publications

The Effectiveness of Neutrophil-Lymphocyte Ratio in Predicting in-Hospital Mortality in Non-ST-Elevation Myocardial Infarction

The Effectiveness of Neutrophil-Lymphocyte Ratio in Predicting in-Hospital Mortality in Non-ST-Elevation Myocardial Infarction

Predicting value of white cell count and total bilirubin on clinical outcomes in patients with ST-elevation myocardial infarction following percutaneous coronary intervention: a cohort study

Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

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