“…To improve students’ understanding and increase their interests, an alternative method that is more interactive and student centered is really needed. Previous research has revealed that card games can be a useful teaching and learning tool and play an important role in the whole teaching–learning process ( Schneider et al ., 2012 ); however, the target audience in previous studies was often medical students. Moreover, although some of the previous studies have demonstrated that many strategies, such as inquiry-based, problem-based, project-based, or technology-integrated approaches, are beneficial for students to learn immunology or cell biology, they often focus on the impact in the undergraduate or graduate context ( Allen and Tanner, 2003 ; Debard et al ., 2005 ; Millar et al ., 2012 ).…”