White Blood Cell, Procalcitonin, C-Reactive Protein and TNF-α as Prognostic Factors in Pediatric Sepsis

Criteria for Pediatric Sepsis—A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce*

“…6, http://links.lww.com/CCM/G825 ). Pooled estimates did not support a difference between nonsurvivors and survivors in mean glucose ( 50 , 68 , 71 , 72 , 76 ), total bilirubin ( 53 , 58 , 76 , 81 , 85 , 86 ), WBC ( 26 , 43 , 50 , 53 , 58 , 62 , 71 , 75 – 77 , 81 , 83 , 85 , 87 , 89 ), hemoglobin ( 26 , 43 , 50 , 71 , 83 , 85 ), international normalized ratio ( 62 , 81 ), prothrombin time ( 53 , 71 , 76 , 81 , 92 ), activated partial thromboplastin time ( 62 , 71 , 81 , 92 ), and brain natriuretic peptide ( 51 , 66 , 76 ).…”

“…Pooled estimates provide strong support for a difference in the following laboratory measures between nonsurvivors and survivors: lower serum pH ( 53 , 58 , 72 , 75 ), higher lactate ( 43 , 50 , 51 , 53 , 60 – 62 , 65 , 68 , 71 , 72 , 74 – 76 , 81 – 83 ), higher serum base deficit ( 62 , 71 , 75 , 76 , 84 , 85 ), higher urea ( 58 , 76 , 81 , 86 ), higher creatinine ( 53 , 58 , 71 , 76 , 81 , 83 , 85 , 86 ), lower platelet count ( 41 , 43 , 50 , 53 , 58 , 62 , 71 , 77 , 81 , 83 – 85 , 87 , 88 ), lower fibrinogen ( 62 , 81 , 84 , 85 , 87 ), higher potassium ( 62 , 71 , 76 ), lower albumin ( 53 , 76 , 83 ), higher procalcitonin ( 26 , 35 , 43 , 76 , 83 , 85 , 89 – ...…”

The Potential Role of Procalcitonin Compared to C-reactive protein and Neutrophil Lymphocyte Ratio in Prediction of Severity and Outcomes of Acute Corrosive Ingestion

“…In the current study, Creactive protein was the most sensitive biomarker (100%) in predicting the occurrence of complications with a relative low cost; however, it had a low specificity (82.35%) compared to PCT. The low CRP specificity will show many false positive results if it is used alone as a biomarker; hence, Lawang et al (2019) recommended its usage should always be associated with other clinical biomarkers as PCT, to increase its specificity in diagnosis and to assess changes in therapeutic approaches.…”

Procalcitonin, IL-1ß, HSP10 and Resolvin D2 Mechanism as Sepsis Biomarkers in Sepsis Model

“…Delayed diagnosis and initiation of antibiotic therapy have been reported to increase mortality [2,3]. The use of various biomarkers in sepsis has an important role in helping diagnosis and decision making therapy quickly and accurately [4,5]. One marker that has been recognized for the diagnosis and prognosis of sepsis is procalcitonin.…”