White blood cell SPECT during active period of cluster headache and in remission

Steinberg, Anna; Axelsson, Rimma; Ideström, Lars; Müller, Susanne; Remahl, A Ingela M Nilsson

doi:10.1111/j.1468-1331.2011.03456.x

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…One could speculate that the changes in the extracellular space might be related to the sterile inflammation proposed in CH [25]. However recent SPECT study did not find evidence of increased number of intracranial white blood cells in CH [26]. …”

Section: Discussionmentioning

confidence: 99%

White matter disintegration in cluster headache

et al. 2013

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BackgroundPrevious studies in primary headache disorders showed microstructural alterations in the white matter as measured by diffusion imaging. However these investigations are not in full agreement and some of those, especially in cluster headache, restricted the analysis to only a limited number of diffusion parameters. Therefore, in the current study we examined white matter microstructure in cluster headache patients.MethodsDiffusion weighted MRI images with 60 directions were acquired from thirteen patients with cluster headache and sixteen age-matched healthy controls. Tract based spatial statistics were used to compare white matter integrity in the core of the fibre bundles. Correlation of the diffusion parameters with cumulative number of headache days was examined.ResultsThere was a significant increment of the mean, axial and perpendicular diffusivity in widespread white matter regions in the frontal, parietal, temporal and occipital lobes. Reduced fractional anisotropy was found in the corpus callosum and some frontal and parietal white matter tracts mainly in the contralateral side of the pain. Axial diffusivity showed negative correlation to the number of the headache attacks.ConclusionsThe in vivo analysis of microstructural alterations in cluster headache provides important features of the disease, which might offer a deeper insight into the pathomechanism of the disease.

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Section: Discussionmentioning

confidence: 99%

White matter disintegration in cluster headache

et al. 2013

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“…However, initial SPECT studies aimed to explore putative changes in cerebral blood flow (CBF) during spontaneous or triggered CH attacks reported, owing to technical limitations, conflicting results in terms of increased, decreased, or unchanged CBF 18–23 …”

Section: Methodsmentioning

confidence: 99%

“…16,17 However, initial SPECT studies aimed to explore putative changes in cerebral blood flow (CBF) during spontaneous or triggered CH attacks reported, owing to technical limitations, conflicting results in terms of increased, decreased, or unchanged CBF. [18][19][20][21][22][23] In this frame, the CBF has been studied by 133-Xenon inhalation both during CH attacks triggered by alcohol and/or nitroglycerine and outside the attacks. Although no significant global CBF changes occurred from baseline to the CH attacks, the mean regional CBF significantly increased in the central and the basal region, and in a small part of the right parietotemporal region.…”

Section: The Transition From the Vascular Hypothesis To The Trigemino...mentioning

confidence: 99%

Cluster headache pathophysiology: What we have learned from advanced neuroimaging

et al. 2022

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Background Although remarkable progress has been achieved in understanding cluster headache (CH) pathophysiology, there are still several gaps about the mechanisms through which independent subcortical and cortical brain structures interact with each other. These gaps could be partially elucidated by structural and functional advanced neuroimaging investigations. Objective Although we are aware that substantial achievements have come from preclinical, neurophysiological, and biochemical experiments, the present narrative review aims to summarize the most significant findings from structural, microstructural, and functional neuroimaging investigations, as well as the consequent progresses in understanding CH pathophysiological mechanisms, to achieve a comprehensive and unifying model. Results Advanced neuroimaging techniques have contributed to overcoming the peripheral hypothesis that CH is of cavernous sinus pathology, in transitioning from the pure vascular hypothesis to a more comprehensive trigeminovascular model, and, above all, in clarifying the role of the hypothalamus and its connections in the genesis of CH. Conclusion Altogether, neuroimaging findings strongly suggest that, beyond the theoretical model of the “pain matrix,” the model of the “neurolimbic pain network” that is accepted in migraine research could also be extended to CH. Indeed, although the hypothalamus’ role is undeniable, the genesis of CH attacks is complex and seems to not be just the result of a single “generator.” Cortical‐hypothalamic‐brainstem functional interconnections that can switch between out‐of‐bout and in‐bout periods, igniting the trigeminovascular system (probably by means of top‐down mechanisms) and the consensual trigeminal autonomic reflexes, may represent the “neuronal background” of CH.

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“…There is an important aetiological overlap with the tauopathies and motor neuron diseases and genetic advances in this area have implications for the role of tau in Alzheimer's disease. Headache , epilepsy , infection , neuromuscular disease , trauma and neuroinflammation remain important practical diagnostic and management areas for the neurologist. In order to aid in the diagnosis and management of common neurological disorders, the European Federation of Neurological Societies has produced a series of guidelines and these continue to be developed and updated , providing an important resource and evidence base for clinicians.…”

mentioning

confidence: 99%