White blood cell subtypes and neutrophil extracellular traps content as biomarkers for stroke etiology in acute ischemic stroke clots retrieved by mechanical thrombectomy

Jabrah, Duaa; Rossi, Rosanna; Molina, Sara; Douglas, Andrew; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Ceder, Eric; Fitzgerald, Seán; Dunker, Dennis; Nordanstig, Annika; Redfors, Petra; Tatlisumak, Turgut; O'Hare, Alan; Power, Sarah; Brennan, Paul; Owens, Peter; Nagy, András; Vadász, Ágnes; De Meyer, Simon F.; Tsivgoulis, Georgios; Psychogios, Klearchos; Szikora, Istvan; Jood, Katarina; Rentzos, Alexandros; Thornton, John; Doyle, Karen

doi:10.1016/j.thromres.2023.12.005

Cited by 4 publications

(4 citation statements)

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“…Overall, these results suggest that the development of platelet-rich thrombus depends on NET formation [122]. Moreover, recent studies observed differences in neutrophil presence and NET expression in clots from various etiologies, indicating that this may add information to the mechanism of clot formation [111,[123][124][125]. It was observed that cardioembolic clots have a higher content of NETs in comparison to both atherothrombotic and cryptogenic clots [111,[123][124][125].…”

Section: The Role Of Nets In Thrombosismentioning

confidence: 71%

“…Moreover, recent studies observed differences in neutrophil presence and NET expression in clots from various etiologies, indicating that this may add information to the mechanism of clot formation [111,[123][124][125]. It was observed that cardioembolic clots have a higher content of NETs in comparison to both atherothrombotic and cryptogenic clots [111,[123][124][125]. Additionally, Jabrah et al have shown differences in NET distribution in clots of various etiology, located either at the periphery of the thrombus, in the center, or a combination of both [123].…”

Section: The Role Of Nets In Thrombosismentioning

confidence: 99%

“…It was observed that cardioembolic clots have a higher content of NETs in comparison to both atherothrombotic and cryptogenic clots [111,[123][124][125]. Additionally, Jabrah et al have shown differences in NET distribution in clots of various etiology, located either at the periphery of the thrombus, in the center, or a combination of both [123].…”

Section: The Role Of Nets In Thrombosismentioning

confidence: 99%

See 2 more Smart Citations

The Role of Neutrophils in Multiple Sclerosis and Ischemic Stroke

Nowaczewska-Kuchta,

Ksiazek-Winiarek,

Szpakowski

et al. 2024

Brain Sciences

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Inflammation plays an important role in numerous central nervous system (CNS) disorders. Its role is ambiguous—it can induce detrimental effects, as well as repair and recovery. In response to injury or infection, resident CNS cells secrete numerous factors that alter blood–brain barrier (BBB) function and recruit immune cells into the brain, like neutrophils. Their role in the pathophysiology of CNS diseases, like multiple sclerosis (MS) and stroke, is highly recognized. Neutrophils alter BBB permeability and attract other immune cells into the CNS. Previously, neutrophils were considered a homogenous population. Nowadays, it is known that various subtypes of these cells exist, which reveal proinflammatory or immunosuppressive functions. The primary goal of this review was to discuss the current knowledge regarding the important role of neutrophils in MS and stroke development and progression. As the pathogenesis of these two disorders is completely different, it gives the opportunity to get insight into diverse mechanisms of neutrophil involvement in brain pathology. Our understanding of the role of neutrophils in CNS diseases is still evolving as new aspects of their activity are being unraveled. Neutrophil plasticity adds another level to their functional complexity and their importance for CNS pathophysiology.

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Section: The Role Of Nets In Thrombosismentioning

confidence: 71%

Section: The Role Of Nets In Thrombosismentioning

confidence: 99%

Section: The Role Of Nets In Thrombosismentioning

confidence: 99%

See 1 more Smart Citation

The Role of Neutrophils in Multiple Sclerosis and Ischemic Stroke

Nowaczewska-Kuchta,

Ksiazek-Winiarek,

Szpakowski

et al. 2024

Brain Sciences

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“…AT thrombi exhibit a greater abundance of lymphocytes, whereas cryptogenic thrombi display a reduced presence of macrophages. Remarkably, CE clots exhibit increased neutrophil and extracellular reticular NET expression [ 50 ]. NETs play a significant role in a diverse array of illnesses.…”

Section: The Role Of Nets In Stroke Pathologymentioning

confidence: 99%

A promising frontier: targeting NETs for stroke treatment breakthroughs

Fang,

Bo,

Hao

et al. 2024

Cell Commun Signal

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Stroke is a prevalent global acute cerebrovascular condition, with ischaemic stroke being the most frequently occurring type. After a stroke, neutrophils accumulate in the brain and subsequently generate and release neutrophil extracellular traps (NETs). The accumulation of NETs exacerbates the impairment of the blood‒brain barrier (BBB), hampers neovascularization, induces notable neurological deficits, worsens the prognosis of stroke patients, and can facilitate the occurrence of t-PA-induced cerebral haemorrhage subsequent to ischaemic stroke. Alternative approaches to pharmacological thrombolysis or endovascular thrombectomy are being explored, and targeting NETs is a promising treatment that warrants further investigation.

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