1969
DOI: 10.1136/bmj.4.5675.67
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White blood count in patients on regular haemodialysis

Abstract: Summary: Total white cell, neutrophil, and lymphocyte counts were compared in patients with chronic renal failure treated successively by conservative means (lowprotein diet), regular haemodialysis, and renal allotransplantation. The lowest total white cell and neutrophil counts and the highest lymphocyte counts were found in patients on regular haemodialysis. A rapid fall in neutrophil count during the first half-hour of dialysis and a more gradual fall between the first and sixth hours were observed. Adheren… Show more

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Cited by 25 publications
(3 citation statements)
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“…Varying degrees of lymphopenia as well as lymphocyte functional abnormalities have been noted in end-stage renal disease patients and patients on maintenance hemodialysis. 7,8 This includes decreased proliferative response to concanavalin A, phytohemagglutin, cell surface antigens, and decreased production of interleukins along with increased apoptosis of Th subsets. Chronic hemodialysis patients and patients with advanced chronic kidney disease not on dialysis are noted to have their T lymphocytes in an aberrant state of activation, as shown by more CD3 + CD69 + T cell, which drives them into early apoptosis, thereby causing lymphopenia.…”
Section: Discussionmentioning
confidence: 99%
“…Varying degrees of lymphopenia as well as lymphocyte functional abnormalities have been noted in end-stage renal disease patients and patients on maintenance hemodialysis. 7,8 This includes decreased proliferative response to concanavalin A, phytohemagglutin, cell surface antigens, and decreased production of interleukins along with increased apoptosis of Th subsets. Chronic hemodialysis patients and patients with advanced chronic kidney disease not on dialysis are noted to have their T lymphocytes in an aberrant state of activation, as shown by more CD3 + CD69 + T cell, which drives them into early apoptosis, thereby causing lymphopenia.…”
Section: Discussionmentioning
confidence: 99%
“…Transient leukocytopenia (data not shown) and neutropenia during hemodialysis were observed in all three tested groups, findings which are thought to be the result of neutrophil sequestration within the pulmonary vasculature. [11][12][13][14] Changes in the defensin levels were not as marked as alterations in neutrophil counts. Unlike the findings in the PMMA and PS groups, the postdialysis defensin levels in the CU group were increased compared with predialysis values.…”
Section: Discussionmentioning
confidence: 99%
“…Transient leukopenia during dialysis has long since been reported (8,9) and used as a measure of biocompatibility. Dialysis membrane material can be divided into three types: regenerated cellulose; other cellulose with the surface OH group modified (e.g.…”
Section: Discussionmentioning
confidence: 99%