The student population in the United States is becoming increasingly racially and culturally diverse. However, many teachers and educators are not properly equipped to teach diverse students. The importance of teacher professional development in the area of culturally responsive pedagogy and the subsequent effects on student learning cannot be overemphasized. While several research studies have examined culturally responsive pedagogy as a theoretical concept, more work is needed in its practical application and implementation in the classroom. This chapter discusses best practices for infusing culturally responsive strategies and interventions into classroom teaching.