White-coat hypertension is a risk factor for cardiovascular diseases and total mortality

Abstract

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Prevalence and clinical outcomes of white‐coat and masked hypertension: Analysis of a large ambulatory blood pressure database

“…Univariate and multivariate analyses for the risk of developing the predefined CV outcomes are shown in CV risk profile, thus leading to higher risk of experiencing major CV events. [15][16][17][18][19][20][21][22][23][24][25][26][27] Our analysis is consistent with this hypothesis and with the main findings of previous clinical studies, performed in the setting of Italian, 28,29 Spanish, 30 Afro-American, 31 and Japanese 32 outpatients. These analyses, in fact, reported a higher risk of developing CV accidents in patients with WCHT or MHT compared to NT.…”

“…In the recent years, however, several studies suggest that temporal and time‐limiting increases in BP levels, measured in out‐of‐office settings, and mostly during the night‐time, can be related to a substantially higher risk of developing HT‐related complications than those predicted on the basis of clinic BP assessment . These observations suggest a potential role of clinical conditions, such as WCHT and MHT, in the pathophysiological processes involved in the development and progression of structural and functional abnormalities that can be found at cardiac and vessel levels in asymptomatic hypertensive patients at different CV risk profile, thus leading to higher risk of experiencing major CV events . Our analysis is consistent with this hypothesis and with the main findings of previous clinical studies, performed in the setting of Italian, Spanish, Afro‐American, and Japanese outpatients.…”

“…High clinic (or office) BP levels are strongly and independently related to increased risk of CV outcomes. In the recent years, however, several studies suggest that temporal and time-limiting increases in BP levels, measured in out-of-office settings, and mostly during the night-time, can be related to a substantially higher risk of developing HT-related complications than those predicted on the basis of clinic BP assessment [15][16][17][18][19][20][21][22][23][24][25][26][27]. These observations suggest a potential role of clinical conditions, such as WCHT and MHT, in the pathophysiological processes involved in the development and progression of structural and functional abnormalities that can be found at cardiac and vessel levels in asymptomatic hypertensive patients at different…”

White coat hypertension: European versus American guidelines—A new dilemma

“…3 Originally limited to untreated individuals, the definition has more recently been generalized to individuals treated with BP lowering drugs in whom only clinic BP fails to reach the therapeutic target 1,2 However, challenging this traditional view, an increasing amount of evidence supports the concept that WCH has an intermediate risk between normotension and sustained hypertension.…”

Hypertension outcomes and cardiovascular status in young adults with childhood-diagnosed white coat hypertension

“…Adults with WCH are more likely to progress to sustained hypertension (SH) and to be at increased cardiovascular risk compared with normotensive subjects 2. Since it is unknown whether children with WCH progress to SH,3 we sought to determine hypertension outcomes using ABPM and cardiovascular status in young adults with childhood-diagnosed WCH.…”