White Matter Alterations in Depressive Disorder

He, Enling; Liu, Min; Gong, Sizhu; Fu, Xiaojin; Han, Yuexin; Deng, Fang

doi:10.3389/fimmu.2022.826812

Cited by 18 publications

(10 citation statements)

References 97 publications

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“…These results are consistent with reports that higher depressive dimensional scores were sometimes associated to fewer hospitalizations and fewer relapses at 3 and 5 years 97 , indicating better outcome for these patients, although poorer prognosis was also often reported 98 . Furthermore, the ROIs driving this correlation (CC, CR, CING) are often highlighted in WM DTI studies of depression 99 .…”

Section: Discussionmentioning

confidence: 99%

White Matter Microstructure Alterations in Early Psychosis and Schizophrenia

Pavan,

Alemán-Gómez,

Jenni

et al. 2024

Preprint

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Background and Hypothesis: Studies on schizophrenia feature diffusion magnetic resonance imaging (dMRI) to investigate white matter (WM) anomalies. The heterogeneity in the possible interpretations of these metrics highlights the importance of increasing their specificity. Here, we characterize WM pathology in early psychosis (EP) and schizophrenia (SZ) with increased specificity using advanced dMRI metrics: Diffusion Kurtosis Imaging and White Matter Track Integrity - Watson (WMTI-W) biophysical model. This enables us to better characterize WM abnormalities and relate them to symptomatology. Study Design: dMRI-derived microstructure features were extracted from all of WM and from individual tracts in 275 individuals. 93 patients with EP and 47 with SZ were compared respectively to 135 age-range matched healthy controls (HC). The relationships between the dMRI metrics in WM and various clinical scales were investigated in each patient group. Study Results: WM diffusivities were higher, while kurtosis was lower in EP and SZ vs HC. Differences were more pronounced in EP than SZ. WMTI-W model parameters suggest alterations to the extra-axonal compartment in EP and SZ, consistent with abnormal myelin integrity and WM deterioration. Patient groups showed clustered but non-significant correlations between dMRI metrics and psychotic symptoms. Depressive dimensions were significantly associated with decreased diffusivities in WM, while manic scales correlated with increased diffusivities and reduced kurtosis. Conclusions: dMRI patterns in EP and SZ highly suggest WM deterioration in comparison to HC. DMRI changes better align with affective dimensions, while the relationship with psychotic symptoms may be confounded by competing pathological effects on the microstructure and disease heterogeneity.

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Section: Discussionmentioning

confidence: 99%

White Matter Microstructure Alterations in Early Psychosis and Schizophrenia

Pavan,

Alemán-Gómez,

Jenni

et al. 2024

Preprint

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“…Another interesting observation in our present study was that besides the higher depression proportion, the AG group exhibited poorer WM microstructure integrity than the AA group, mainly in CC, internal capsule, corona radiata and fornix. These WM tracts have been reported to have decreased FA in MDD (91)(92)(93)(94). Vulser et al have investigated the association of subthreshold depression with WM microstructure alterations in adolescents and found that decreased FA in the anterior body and genu of CC in adolescents with subthreshold depression (95).…”

Section: Discussionmentioning

confidence: 99%

Per1 gene polymorphisms influence the relationship between brain white matter microstructure and depression risk

et al. 2022

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BackgroundCircadian rhythm was involved in the pathogenesis of depression. The detection of circadian genes and white matter (WM) integrity achieved increasing focus for early prediction and diagnosis of major depressive disorder (MDD). This study aimed to explore the effects of PER1 gene polymorphisms (rs7221412), one of the key circadian genes, on the association between depressive level and WM microstructural integrity.Materials and methodsDiffusion tensor imaging scanning and depression assessment (Beck Depression Inventory, BDI) were performed in 77 healthy college students. Participants also underwent PER1 polymorphism detection and were divided into the AG group and AA group. The effects of PER1 genotypes on the association between the WM characteristics and BDI were analyzed using tract-based spatial statistics method.ResultsCompared with homozygous form of PER1 gene (AA), more individuals with risk allele G of PER1 gene (AG) were in depression state with BDI cutoff of 14 (χ2 = 7.37, uncorrected p = 0.007). At the level of brain imaging, the WM integrity in corpus callosum, internal capsule, corona radiata and fornix was poorer in AG group compared with AA group. Furthermore, significant interaction effects of genotype × BDI on WM characteristics were observed in several emotion-related WM tracts. To be specific, the significant relationships between BDI and WM characteristics in corpus callosum, internal capsule, corona radiata, fornix, external capsule and sagittal stratum were only found in AG group, but not in AA group.ConclusionOur findings suggested that the PER1 genotypes and emotion-related WM microstructure may provide more effective measures of depression risk at an early phase.

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“…On the other hand, tractography is a visualization technique that reconstructs and maps the pathways of WM tracts in the brain based on DTI data ( 19 ). In particular, in MDD structural disruptions within WM tissue are reflected by decreased FA mainly localized in the corpus callosum (CC), cingulum and uncinate fasciculus ( 20 ). Moreover, reduction of FA has been found correlating with severity of depressive symptomatology ( 21 ) and MDD duration ( 22 ), probably explaining the impairments in general cognitive functioning often observed in these patients according to anatomical disruptions ( 23 ).…”

Section: Introductionmentioning

confidence: 99%

White matter integrity and medication response to antidepressants in major depressive disorder: a review of the literature

Videtta,

Squarcina,

Prunas

et al. 2024

Front. Psychiatry

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Major Depressive Disorder (MDD) is a severe psychiatric disorder characterized by selective impairments in mood regulation, cognition and behavior. Although it is well-known that antidepressants can effectively treat moderate to severe depression, the biochemical effects of these medications on white matter (WM) integrity are still unclear. Therefore, the aim of the study is to review the main scientific evidence on the differences in WM integrity in responders and non-responders to antidepressant medications. A record search was performed on three datasets (PubMed, Scopus and Web of Science) and ten records matched our inclusion criteria. Overall, the reviewed studies highlighted a good efficacy of antidepressants in MDD treatment. Furthermore, there were differences in WM integrity between responders and non-responders, mainly localized in cingulate cortices, hippocampus and corpus callosum, where the former group showed higher fractional anisotropy and lower axial diffusivity values. Modifications in WM integrity might be partially explained by branching and proliferation as well as neurogenesis of axonal fibers mediated by antidepressants, which in turn may have positively affected brain metabolism and increase the quantity of the serotonergic neurotransmitter within synaptic clefts. However, the reviewed studies suffer from some limitations, including the heterogeneity in treatment duration, antidepressant administration, medical posology, and psychiatric comorbidities. Therefore, future studies are needed to reduce confounding effects of antidepressant medications and to adopt longitudinal and multimodal approaches in order to better characterize the differences in WM integrity between responders and non-responders.

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White Matter Alterations in Depressive Disorder

Cited by 18 publications

References 97 publications

White Matter Microstructure Alterations in Early Psychosis and Schizophrenia

White Matter Microstructure Alterations in Early Psychosis and Schizophrenia

Per1 gene polymorphisms influence the relationship between brain white matter microstructure and depression risk

White matter integrity and medication response to antidepressants in major depressive disorder: a review of the literature

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