White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

Fusar‐Poli, Paolo; Crossley, Nicolás; Woolley, James B.; Carletti, Francesco; Pérez-Iglesias, Rocí­o; Broome, Matthew R.; Johns, Louise; Tabraham, Paul; Bramon, Elvira; McGuire, Philip

doi:10.1503/jpn.100083

Cited by 49 publications

(45 citation statements)

References 67 publications

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“…This study was the first to identify WM deficits in a non-treatment seeking sample of at-risk children and gives rise to the notion that these subtle microstructural differences in WM integrity may be apparent not only in the risk state but are identifiable at a younger age than previously suspected. Reduced WM volume within the superior temporal lobe has also been found in high-risk subjects compared to healthy controls [118,119]. Increased corticial thinning over time within the superior temporal gyrus has also been found to be predictive of CHR who convert to psychosis compared to those who did not [120].…”

Section: Clinical High-riskmentioning

confidence: 93%

“…Increased corticial thinning over time within the superior temporal gyrus has also been found to be predictive of CHR who convert to psychosis compared to those who did not [120]. A multimodal imaging study has uncovered a direct association between the WM volume underlying the right supramar- ginal gyrus extending into the right arcuate fasciculus and the electrophysiological alterations (as measured with P300 amplitude) of CHR subjects [121] Such correlation was pathological as it was observed in the CHR but not in the control group. Previous MRI-EEG studies showed that superior temporal gyrus volume is associated with smaller P300 in chronic [122] and first episode [123] schizophrenia.…”

Section: Clinical High-riskmentioning

confidence: 96%

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The Relationship of Developmental Changes in White Matter to the Onset of Psychosis

Karlsgodt¹,

Jacobson²,

Seal³

et al. 2012

CPD

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Schizophrenia is a disorder with a pronounced developmental component. Accordingly, there is a growing interest in characterizing developmental changes in the period leading up to disease onset, in an effort to develop effective preventative interventions. One of the ongoing neurodevelopmental changes known to occur in the late adolescent period that often overlaps with the prodromal phase and time of onset is white matter development and myelination. In this critical review, a disruption in the normal trajectory of white matter development could potentially play an important role in the onset of psychosis. We seek to summarize the existing state of research on white matter development in prodromal subjects, with a particular focus on diffusion tensor imaging (DTI) measures. First, we describe the physiological basis of developmental white matter changes and myelination. Next, we characterize the pattern of white matter changes associated with typical development across adolescence as measured with DTI. Then, we discuss white matter changes observed in adult patients with schizophrenia and in individuals seen in genetic and clinical high risk states. Finally, we discuss the implications of these findings for future research directions and for potential therapeutic interventions.

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Section: Clinical High-riskmentioning

confidence: 93%

Section: Clinical High-riskmentioning

confidence: 96%

The Relationship of Developmental Changes in White Matter to the Onset of Psychosis

Karlsgodt¹,

Jacobson²,

Seal³

et al. 2012

CPD

Self Cite

View full text Add to dashboard Cite

show abstract

“…In brief, CHR groups manifest reduced amplitude relative to HCs and the magnitude of reduction discriminates converters from nonconverters. 50 P300 amplitude is also linked to white and gray matter volume, 51 suggesting that functional brain impairments tapped by neurophysiologic indices reflect structural brain abnormalities.…”

Section: Imagingmentioning

confidence: 99%

The Prodrome and Clinical Risk for Psychotic Disorders

Holtzman

Trotman

Ryan

et al. 2013

Child and Adolescent Psychiatric Clinics of North America

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“…Investigations employing the P3 component, which is thought to reflect automatic processing of novelty and memory updating, have demonstrated significant deficits in at-risk subjects compared to healthy controls (44, 59, 62, 65, 70–76). Thereby, the P3 deficit in the at-risk state seems to be tantamount to the impairment observed in first-episode psychosis, but less severe compared to recent onset and chronic schizophrenia, respectively (44, 59, 62, 65, 72, 75).…”

Section: Information Processing In Psychosis Developmentmentioning

confidence: 99%

“…Nine studies have been identified that statistically compared neurophysiological measures in converters vs. non-converters (25, 47, 50, 52, 53, 61, 63, 70, 71, 73) (see Table 2 for overview).…”

Section: Information Processing In Psychosis Developmentmentioning

confidence: 99%

Basic Disturbances of Information Processing in Psychosis Prediction

Bodatsch¹,

Klosterkötter²,

Müller³

et al. 2013

Front. Psychiatry

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The basic symptoms (BS) approach provides a valid instrument in predicting psychosis onset and represents moreover a significant heuristic framework for research. The term “basic symptoms” denotes subtle changes of cognition and perception in the earliest and prodromal stages of psychosis development. BS are thought to correspond to disturbances of neural information processing. Following the heuristic implications of the BS approach, the present paper aims at exploring disturbances of information processing, revealed by functional magnetic resonance imaging (fMRI) and electro-encephalographic as characteristics of the at-risk state of psychosis. Furthermore, since high-risk studies employing ultra-high-risk criteria revealed non-conversion rates commonly exceeding 50%, thus warranting approaches that increase specificity, the potential contribution of neural information processing disturbances to psychosis prediction is reviewed. In summary, the at-risk state seems to be associated with information processing disturbances. Moreover, fMRI investigations suggested that disturbances of language processing domains might be a characteristic of the prodromal state. Neurophysiological studies revealed that disturbances of sensory processing may assist psychosis prediction in allowing for a quantification of risk in terms of magnitude and time. The latter finding represents a significant advancement since an estimation of the time to event has not yet been achieved by clinical approaches. Some evidence suggests a close relationship between self-experienced BS and neural information processing. With regard to future research, the relationship between neural information processing disturbances and different clinical risk concepts warrants further investigations. Thereby, a possible time sequence in the prodromal phase might be of particular interest.

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White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

Cited by 49 publications

References 67 publications

The Relationship of Developmental Changes in White Matter to the Onset of Psychosis

The Relationship of Developmental Changes in White Matter to the Onset of Psychosis

The Prodrome and Clinical Risk for Psychotic Disorders

Basic Disturbances of Information Processing in Psychosis Prediction

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