White matter changes and the development of motor phenotypes in de novo Parkinson's Disease

Differential White Matter Regional Alterations in Motor Subtypes of Early Drug-Naive Parkinson’s Disease Patients

“…More WM pathology in PIGD, but not in TD, was previously noted in studies examining WM lesions on fluid-attenuated inversion recovery (FLAIR) images. [51][52][53] Findings from our current study further demonstrated that the WM microstructural alterations occurred even in early and drug-naive PIGD patients. While we observed significant group differences in WM voxel-wise properties from TBSS analysis, we did not find any network changes in this early PD cohort.…”

Frontal Tasks and Behavior in Rigid or Tremor-Dominant Parkinson Disease

“…It has been reported that there are many differences between motor phenotypes, possibly related to different factors such as DA deficits and concomitant white matter disease, which indeed could be involved in cognitive and behavioral aspects of PD. 4 -6,22,23 Our study has limited the possibility of enrolling patients with white matter vascular involvement, employing specific neuroimaging instruments, and with other neuropsychiatric conditions. The differences between the clinical pattern profiles have been managed by UPDRS III 3 and by our choice of MDS-UPDRS subitems.…”

Parkinson’s Disease and Fabry Disease: Clinical, Biochemical and Neuroimaging Analysis of Three Pedigrees

“…This observation raises the question whether cerebrovascular lesions, highly frequent in FD [30], increase by themselves the risk of PD and/or instead alter its phenotype. Also, even though the criteria for pure Vascular Parkinsonism are still controversial [31,32], cerebrovascular lesions probably alter the natural history of PD, conditioning a more severe, axial phenotype of PD [33], as we may have observed in our study.…”