White matter changes in drug-naïve Parkinson's disease patients with impulse control &amp; probable REM sleep behavior disorders

Dolatshahi, Mahsa; Ashraf‐Ganjouei, Amir; Wu, I‐Wei; Aarabi, Mohammad Hadi; Tosun, Duygu; Initiative, Parkinson's Progression Marker

doi:10.1016/j.jns.2021.120032

Cited by 7 publications

(5 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, superior longitudinal fasciculus presented increased MD, partly increase in AD or RD in PD patients with VBD, which may be correlated with freezing gait episodes in PD patients by impairing visuospatial coordination of movement [40,41], possibly due to restoration or demyelination [32]. Moreover, FX and ST, composed of associative fibers from hippocampus and amygdala, respectively, presented increased AD in PD patients with VBD, which may be correlated with PD-related anxiety, depression and sleep behavior disorders [2,38,42], possibly due to re-establishing or an increase in diffusion parallel to axon out of cellular debris removal [32].…”

Section: Discussionmentioning

confidence: 99%

Increased prevalence of vertebrobasilar dolichoectasia in Parkinson’s disease and its effect on white matter microstructure and network

Li,

Zhu,

Lai

et al. 2024

NeuroReport

View full text Add to dashboard Cite

This study aimed to investigate the prevalence of vertebrobasilar dolichoectasia (VBD) in Parkinson’s disease (PD) patients and analyze its role in gray matter changes, white matter (WM) microstructure and network alterations in PD. This is a cross-sectional study including 341 PD patients. Prevalence of VBD in these PD patients was compared with general population. Diffusion tensor imaging and T1-weighted imaging analysis were performed among 174 PD patients with or without VBD. Voxel-based morphometry analysis was used to estimate gray matter volume changes. Tract-based spatial statistics and region of interest-based analysis were used to evaluate WM microstructure changes. WM network analysis was also performed. Significantly higher prevalence of VBD in PD patients was identified compared with general population. Lower fractional anisotropy and higher diffusivity, without significant gray matter involvement, were found in PD patients with VBD in widespread areas. Decreased global and local efficiency, increased hierarchy, decreased degree centrality at left Rolandic operculum, increased betweenness centrality at left postcentral gyrus and decreased average connectivity strength between and within several modules were identified in PD patients with VBD. VBD is more prevalent in PD patients than general population. Widespread impairments in WM microstructure and WM network involving various motor and nonmotor PD symptom–related areas are more prominent in PD patients with VBD compared with PD patients without VBD.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased prevalence of vertebrobasilar dolichoectasia in Parkinson’s disease and its effect on white matter microstructure and network

Li,

Zhu,

Lai

et al. 2024

NeuroReport

View full text Add to dashboard Cite

show abstract

“…In addition, in patients with PD with impulse control disorder, the FA of the corpus callosum, the posterior limb of the right internal capsule, the right posterior cingulate, and the right thalamic radiation were signi cantly higher than in patients without impulse control disorder [13]. Also, a retrospective study manifested that PD without complications (impulse control disorder, dementia) was associated with better WM integrity [14]. Kamiy et al also found that WM degeneration was correlated with the severity of motor impairment in PD [12].…”

Section: Introductionmentioning

confidence: 92%

Predicting Clinical Respondence of Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease Using White Matter Functional Characteristics

Lv,

Xing,

Feng

et al. 2024

Preprint

View full text Add to dashboard Cite

Objective The aim of this study was to predict the clinical respondence of rTMS in PD by WM.Methods According to the Unified Parkinson’s Disease Rating Scale Part III (UPDRSIII) score reduction, Sixty-eight PD patients treated with rTMS for 14 days were divided into a responsive (R) group (UPDRSIII score reduction ≥ 30%, n = 20) and a nonresponsive (NR) group (UPDRSIII score reduction ≤ 30%, n = 48). The difference of low frequency fluctuation amplitude (ALFF) and fraction ALFF (fALFF) before rTMS and the correlation with UPDRSIII improvement were analyzed between the two groups.Results The ALFF values of the bilateral upper corticospinal tract and fALFF values of the left anterior thalamic radiation in R group were higher than those in NR group. The ALFF value of the bilateral superior longitudinal fasciculus, the bilateral lower corticospinal tract, the left Forceps major and the right anterior thalamic radiation in R group was lower than that in NR group. Pearson correlation analysis showed that the UPDRSIII deduction score was positively correlated with the bilateral upper corticospinal fasciculus and bilateral anterior thalamic radiation and negatively correlated with the bilateral lower corticospinal tract and the bilateral superior longitudinal fasciculus. The ALFF value of the upper right corticospinal tract and the lower right corticospinal tract and the fALFF value of the bilateral anterior thalamic radiation were included in the prediction model, and the prediction efficiency was 100%.Conclusion WM could be used as a predictor of the clinical efficacy of rTMS in PD.

show abstract

“…There are also a handful of studies that suggest an association between fornix damage and sleep disturbances, yet to our knowledge, these sleep disturbances have not been linked to memory impairment. Disrupted sleep patterns, including excessive daytime sleepiness and REM sleep behaviour disorder, are associated with lower connectivity in the fornix (Ghazi Sherbaf et al, 2018;Matsui et al, 2006;Dolatshahi et al, 2021), indicating that alterations to the fornix may cause changes in sleep quality. Fornix damage was also associated with abnormal sleep behaviour in patients with amyotrophic lateral sclerosis (ALS; Gabery et al, 2021).…”

Section: Sleep Differentially and Profoundly Impairs Recall Memory In...mentioning

confidence: 99%

Sleep Differentially and Profoundly Impairs Recall Memory in a Patient with Fornix Damage

Matorina

Tseng

Ladyka‐Wojcik

et al. 2023

Journal of Cognitive Neuroscience

View full text Add to dashboard Cite

In March 2020, C.T., a kind, bright, and friendly young woman underwent surgery for a midline tumor involving her septum pellucidum and extending down into her fornices bilaterally. Following tumor diagnosis and surgery, C.T. experienced significant memory deficits: C.T.'s family reported that she could remember things throughout the day, but when she woke up in the morning or following a nap, she would expect to be in the hospital, forgetting all the information that she had learned before sleep. The current study aimed to empirically validate C.T.'s pattern of memory loss and explore its neurological underpinnings. On two successive days, C.T. and age-matched controls watched an episode of a TV show and took a nap or stayed awake before completing a memory test. Although C.T. performed numerically worse than controls in both conditions, sleep profoundly exacerbated her memory impairment, such that she could not recall any details following a nap. This effect was replicated in a second testing session. In high-resolution MRI scans, we observed evidence of the trans-callosal surgical approach's impact on the mid-anterior corpus callosum, showed that C.T. had perturbed white matter particularly in the right fornix column, and demonstrated that C.T.'s hippocampal volumes did not differ from controls. These findings suggest that the fornix is important for processing episodic memories during sleep. As a key output pathway of the hippocampus, the fornix may ensure that specific memories are replayed during sleep, maintain the balance of sleep stages, or allow for the retrieval of memories following sleep.

show abstract

White matter changes in drug-naïve Parkinson's disease patients with impulse control & probable REM sleep behavior disorders

Cited by 7 publications

References 73 publications

Increased prevalence of vertebrobasilar dolichoectasia in Parkinson’s disease and its effect on white matter microstructure and network

Increased prevalence of vertebrobasilar dolichoectasia in Parkinson’s disease and its effect on white matter microstructure and network

Predicting Clinical Respondence of Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease Using White Matter Functional Characteristics

Sleep Differentially and Profoundly Impairs Recall Memory in a Patient with Fornix Damage

Contact Info

Product

Resources

About