White Matter Correlates of Cognitive Impairment in Essential Tremor

Bhalsing, Ketaki Swapnil; Kumar, Keshav; Saini, Jitender; Yadav, Ravi; Gupta, Arun Kumar; Pal, Pramod Kumar

doi:10.3174/ajnr.a4138

Cited by 34 publications

(30 citation statements)

References 40 publications

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“…Since PWT has overlapping features with ET and WC, it becomes important to evaluate the neuropsychological profile in these patients to get a better insight into the pathogenesis of the disorder. In our study, there was decreased FA value in structures such as ATR, IFO, and ILF which had significant correlation with testrelated executive domain in patients with ET as highlighted by Bhalsing et al [35]. In addition, many areas found to be significantly involved in our study have been implicated to have a role in psychiatric disorders such as bilateral posterior cingulate gyrus and precuneus in early Alzheimer's disease (AD) [37].…”

Section: Discussionsupporting

confidence: 52%

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A preliminary study of the neuroanatomical correlates of primary writing tremor: role of cerebellum

et al. 2016

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Section: Discussionsupporting

confidence: 52%

“…Bhalsing et al [34] in their study on ET have found significant gray matter atrophy correlating with impaired cognitive domains. In another study, Bhalsing et al [35] reported a significant correlation between scores of neuropsychological test and DTI parameters in ET.…”

Section: Discussionmentioning

confidence: 96%

A preliminary study of the neuroanatomical correlates of primary writing tremor: role of cerebellum

et al. 2016

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“…The areas outside CTC were linked to nonmotor ET symptoms (Benito‐León et al., 2017; Bhalsing et al., 2014, 2015), which provides further evidence for the pathophysiological complexity of ET.…”

Section: Introductionmentioning

confidence: 67%

“…WM microstructure in abovementioned bundles was related to various neuropsychological outcomes in ET (Bhalsing et al., 2015), while our study linked WM blobs within these tracts to objective tremor measurements reflecting abnormal motor functions. These relationships were in partial agreement with an association between FTM scale and fronto‐parietal WM deficits demonstrated previously (Klein et al., 2011).…”

Section: Discussionmentioning

confidence: 92%

“…Also, atrophy in frontal and temporal gray matter regions, which are interconnected by UF, was found related to the FTM scale (Bagepally et al., 2012) and an improvement of WM integrity within the ILF and IFOF was consistently reported among longitudinal DTI studies evaluating effects of physical training (Huang, Lu, Song, & Wang, 2015; Scholz et al., 2009), implying their involvement in motor functions. However, the absence of comprehensive psychological evaluations does not allow us to rule out the possibility that WM abnormalities detected in ET patients are to certain level related to psychological deficits as published previously (Benito‐León et al., 2017; Bhalsing et al., 2015). Future studies with particular focus on the examination of different impacts of both cognitive and motor signs on WM substrate are certainly warranted.…”

Section: Discussionmentioning

confidence: 99%

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White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study

et al. 2018

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BackgroundAn evolving pathophysiological concept of essential tremor (ET) points to diffuse brain network involvement, which emphasizes the need to investigate white matter (WM) changes associated with motor symptoms of ET.ObjectivesTo investigate ET‐related WM changes and WM correlates of tremor severity using tremor clinical rating scales and accelerometry.MethodsTract‐based spatial statistics (TBSS) approach was utilized to compare 3 Tesla diffusion tensor imaging (DTI) data from 12 ET patients and 10 age‐ and gender‐matched healthy individuals. Clinical scales, tremor frequency and amplitude as measured by accelerometry were correlated with DTI data.Results ET patients demonstrated mean (MD) and radial diffusivity (RD) abnormalities in tracts involved in primary and associative motor functions such as bilateral corticospinal tracts, the superior longitudinal fascicles, and the corpus callosum but also in nonmotor regions including the inferior fronto‐occipital and longitudinal fascicles, cingulum bundles, anterior thalamic radiations, and uncinate fascicles. A combined tremor frequency and amplitude score correlated with RD and MD in extensive WM areas, which partially overlapped the regions that were associated with tremor frequency. No significant relationship was found between DTI measures and clinical rating scales scores.ConclusionsThe results show that ET‐related diffusion WM changes and their correlates with tremor severity are preferentially located in the primary and associative motor areas. In contrast, a relationship between WM was not detected with clinical rating scales. Accelerometry parameters may, therefore, serve as a potentially useful clinical measures that relate to WM deficits in ET.

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Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract‐specific analysis study

et al. 2019

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Introduction The corpus callosum serves the essential role of relaying cognitive information between the homologous regions in the left and the right hemispheres of the brain. Cognitive impairment is a core dysfunction of schizophrenia, but much of its pathophysiology is unknown. The aim of this study was to elucidate the association between microstructural abnormalities of the corpus callosum and cognitive dysfunction in schizophrenia. Methods We examined stepwise multiple regression analysis to investigate the relationship of the fractional anisotropy (FA) of callosal fibers in each segment with z ‐scores of each brief assessment of cognition in schizophrenia subtest and cognitive composite score in all subjects (19 patients with schizophrenia [SZ group] and 19 healthy controls [HC group]). Callosal fibers were separated into seven segments based on their cortical projection using tract‐specific analysis of diffusion tensor imaging. Results The FA of callosal fibers in the temporal segment was significantly associated with z ‐scores of token motor test, Tower of London test, and the composite score. In the SZ group, the FA of callosal fibers in the temporal segment was significantly associated with the z ‐score of the Tower of London test. In addition, the FA of callosal fibers in temporal segment showed significant negative association with the positive and negative syndrome scale negative score in the SZ group. Compared to the HC group, the FA in temporal segment was significantly decreased in the SZ group. Conclusion Our results suggest that microstructural abnormalities in the callosal white matter fibers connecting bilateral temporal lobe cortices contribute to poor executive function and severe negative symptom in patients with schizophrenia.

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White Matter Correlates of Cognitive Impairment in Essential Tremor

Abstract: BACKGROUND AND PURPOSE: Impairment of cognitive functions occurs in essential tremor, though the mechanism is largely unknown. The aim of this study was to find microstructural correlates of cognitive dysfunction seen in essential tremor by using DTI and neuropsychological assessment.

Cited by 34 publications

References 40 publications

A preliminary study of the neuroanatomical correlates of primary writing tremor: role of cerebellum

A preliminary study of the neuroanatomical correlates of primary writing tremor: role of cerebellum

White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study

Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract‐specific analysis study

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