White matter diffusion abnormalities in migraine and medication overuse headache: A 1.5-T tract-based spatial statistics study

Shibata, Yasushi; Ishiyama, Sumire; Matsushita, Akira

doi:10.1016/j.clineuro.2018.09.022

Cited by 25 publications

(37 citation statements)

References 34 publications

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“…The lower RTOP values found in patients with EM compared to HC are in line with the most reported result with the MD in previous studies (higher MD in migraines) [ 2 , 5 , 46 , 47 , 48 , 49 , 50 , 51 ], although the opposite result with the MD (lower MD in migraines) has also been reported [ 3 , 6 , 38 , 52 ]. It must be noted that most patients included in previous migraine studies were patients with EM.…”

Section: Discussionsupporting

confidence: 89%

“…However, different DTI studies produce conflicting results. In most studies, the reported values of the fractional anisotropy (FA) were lower in migraine compared to controls in whole brain studies with tract-based spatial statistics (TBSS) [ 2 , 3 , 4 , 5 ], the most employed technique in dMRI migraine studies. Nonetheless, the opposite result, higher FA values in patients with a migraine, has also been found using the same assessment method [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition

et al. 2020

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The white matter state in migraine has been investigated using diffusion tensor imaging (DTI) measures, but results using this technique are conflicting. To overcome DTI measures, we employed ensemble average diffusion propagator measures obtained with apparent measures using reduced acquisitions (AMURA). The AMURA measures were return-to-axis (RTAP), return-to-origin (RTOP) and return-to-plane probabilities (RTPP). Tract-based spatial statistics was used to compare fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity from DTI, and RTAP, RTOP and RTPP, between healthy controls, episodic migraine and chronic migraine patients. Fifty healthy controls, 54 patients with episodic migraine and 56 with chronic migraine were assessed. Significant differences were found between both types of migraine, with lower axial diffusivity values in 38 white matter regions and higher RTOP values in the middle cerebellar peduncle in patients with a chronic migraine (p < 0.05 family-wise error corrected). Significantly lower RTPP values were found in episodic migraine patients compared to healthy controls in 24 white matter regions (p < 0.05 family-wise error corrected), finding no significant differences using DTI measures. The white matter microstructure is altered in a migraine, and in chronic compared to episodic migraine. AMURA can provide additional results with respect to DTI to uncover white matter alterations in migraine.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition

et al. 2020

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“…Previous whole-brain TBSS studies found white matter differences between migraine patients and healthy controls [6][7][8][9][10][11]52]. Most of these studies report decreased FA in migraine patients with respect to healthy controls, but one study showed increased FA in migraineurs with respect to healthy controls; in this study, Messina et al analysed paediatric patients [9], which could explain the difference.…”

Section: Discussionmentioning

confidence: 58%

“…Results for MD and RD in the literature regarding migraine using TBSS are unclear. On the one hand, increased MD and RD values in migraineurs with respect to healthy controls were obtained in [11,52], but on the other hand, decreased values were reported in [7][8][9]. Results obtained with methods different than TBSS, such as ROI-based The column Volume represents the volume from the atlas region with significant differences (FDR-corrected and number of contrasts).…”

Section: Discussionmentioning

confidence: 99%

“…Among its different modalities, diffusion MRI (dMRI) is particularly well suited for the analysis of possible white matter alterations in migraine. dMRI studies have shown changes affecting the white matter in migraineurs with respect to healthy controls; these changes were mainly observed in the corpus callosum [5][6][7][8][9][10][11], thalamus [7,8,12,13], thalamic radiation [7-9, 14, 15] and cingulate gyrus [9,10,[15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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White matter changes in chronic and episodic migraine: a diffusion tensor imaging study

et al. 2020

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Background: White matter alterations have been observed in patients with migraine. However, no microstructural white matter alterations have been found particularly in episodic or chronic migraine patients, and there is limited research focused on the comparison between these two groups of migraine patients. Methods: Fifty-one healthy controls, 55 episodic migraine patients and 57 chronic migraine patients were recruited and underwent brain T1-weighted and diffusion-weighted MRI acquisition. Using Tract-Based Spatial Statistics (TBSS), fractional anisotropy, mean diffusivity, radial diffusivity and axial diffusivity were compared between the different groups. On the one hand, all migraine patients were compared against healthy controls. On the other hand, patients from each migraine group were compared between them and also against healthy controls. Correlation analysis between clinical features (duration of migraine in years, time from onset of chronic migraine in months, where applicable, and headache and migraine frequency, where applicable) and Diffusion Tensor Imaging measures was performed. Results: Fifty healthy controls, 54 episodic migraine and 56 chronic migraine patients were finally included in the analysis. Significant decreased axial diffusivity (p < .05 false discovery rate and by number of contrasts corrected) was found in chronic migraine compared to episodic migraine in 38 white matter regions from the Johns Hopkins University ICBM-DTI-81 White-Matter Atlas. Significant positive correlation was found between time from onset of chronic migraine and mean fractional anisotropy in the bilateral external capsule, and negative correlation between time from onset of chronic migraine and mean radial diffusivity in the bilateral external capsule. Conclusions: These findings suggest global white matter structural differences between episodic migraine and chronic migraine. Patients with chronic migraine could present axonal integrity impairment in the first months of chronic migraine with respect to episodic migraine patients. White matter changes after the onset of chronic migraine might reflect a set of maladaptive plastic changes.

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How to Start a Headache/Migraine Surgery Practice

Branch

MooreIV

Peled³

2020

Surgical Treatment of Chronic Headaches and Migraines

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White matter diffusion abnormalities in migraine and medication overuse headache: A 1.5-T tract-based spatial statistics study

Cited by 25 publications

References 34 publications

Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition

Alternative Microstructural Measures to Complement Diffusion Tensor Imaging in Migraine Studies with Standard MRI Acquisition

White matter changes in chronic and episodic migraine: a diffusion tensor imaging study

How to Start a Headache/Migraine Surgery Practice

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