White matter fractional anisotropy is inversely related to anxious symptoms in older adults with atherosclerosis

Bijanki, Kelly R.; Stillman, Ashley N.; Arndt, Stephan; Magnotta, Vincent A.; Fiedorowicz, Jess G.; Haynes, William G.; Matsui, Joy T.; Johnson, Hans J.; Moser, David J.

doi:10.1002/gps.3930

Cited by 11 publications

(11 citation statements)

References 51 publications

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“…The associations observed with higher MD and lower FA, generally reflective of decreases in fiber integrity and brain connectivity, suggests cerebral microstructural differences exist in type 2 diabetes with anxiety and depression. A previous analysis of older adults with atherosclerosis found reduced WMFA in those with increased anxiety (Bijanki, Stillman et al 2013), and differences in white matter microstructure, as reflected in FA and MD measures, have also been reported in late-life depression (Shimony, Sheline et al 2009). Reductions in GMV have been observed in late life depression (Sexton, Mackay et al 2013) as well as anxiety (Moon, Kim et al 2014).…”

Section: Discussionmentioning

confidence: 89%

Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes

Raffield

Brenes

Cox

et al. 2016

Journal of Diabetes and its Complications

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Structured Abstract Aims Anxiety, depression, accelerated cognitive decline, and increased risk of dementia are observed in individuals with type 2 diabetes. Anxiety and depression may contribute to lower performance on cognitive tests and differences in neuroimaging observed in individuals with type 2 diabetes. Methods These relationships were assessed in 655 European Americans with type 2 diabetes from 504 Diabetes Heart Study families. Participants completed cognitive testing, brain magnetic resonance imaging, the Brief Symptom Inventory Anxiety subscale, and the Center for Epidemiologic Studies Depression-10. Results In analyses adjusted for age, sex, educational attainment, and use of psychotropic medications, individuals with comorbid anxiety and depression symptoms had lower performance on all cognitive testing measures assessed (p≤0.005). Those with both anxiety and depression also had increased white matter lesion volume (p=0.015), decreased gray matter cerebral blood flow (p=4.43 × 10−6), decreased gray matter volume (p=0.002), increased white and gray matter mean diffusivity (p≤0.001), and decreased white matter fractional anisotropy (p=7.79 × 10−4). These associations were somewhat attenuated upon further adjustment for health status related covariates. Conclusions Comorbid anxiety and depression symptoms were associated with cognitive performance and brain structure in a European American cohort with type 2 diabetes.

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Section: Discussionmentioning

confidence: 89%

Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes

Raffield

Brenes

Cox

et al. 2016

Journal of Diabetes and its Complications

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“…The SCL-90-R Depression Scale has shown strong correlation with the Beck Depression Inventory ( Beck et al, 1988 ), suggesting convergent validity ( Steer et al, 1994 ). Previous analysis by our group has shown that scores on the SCL-90-R are suitably sensitive to show relationships with brain structural measures ( Bijanki et al, 2013b ). In the parent study of 111 AVD and 51 HC participants, the AVD participants had significantly elevated SCL-90-R depression scores compared with the HC participants (AVD mean 55.18, HC mean 50.67, t = 2.466, df = 160, p = 0.015), supporting the premise that AVD participants experience elevated levels of depressive symptoms.…”

Section: Methodsmentioning

confidence: 98%

Depressive symptoms related to low fractional anisotropy of white matter underlying the right ventral anterior cingulate in older adults with atherosclerotic vascular disease

Bijanki

Matsui

Mayberg

et al. 2015

Front. Hum. Neurosci.

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We sought to characterize the relationship between integrity of the white matter underlying the ventral anterior cingulate (vAC) and depressive symptoms in older adults with atherosclerotic vascular disease (AVD), a condition associated with preferential degeneration of the white matter. The vAC was defined as including white matter underlying ventral Brodmann Area 24 and Brodmann Area 25, corresponding with the “subcallosal” and “subgenual” cingulate respectively. This region of interest was chosen based on the preponderance of evidence that the white matter in the region plays a critical role in the manifestation of depressive symptoms. Participants had current unequivocal diagnoses of AVD and were between 55 and 90 years-old. Fractional anisotropy (FA) was used as an index of white matter integrity and organization. Whole-brain mean diffusivity (MD) was used as an index of global white matter lesion burden. Depressive symptoms were measured using the Symptom Checklist-90-Revised (SCL-90-R) Depression Scale. Depressive symptoms were significantly related to low FA in the right vAC (r = -0.356, df = 30, p = 0.045) but not the left vAC (r = 0.024, df = 30, p = 0.896) after controlling for total brain MD (a statistical control for global white matter lesion burden). Further, depressive symptoms were significantly related to low FA in the right vAC (r = -0.361, df = 31, p = 0.039), but not the left vAC (r = 0.259, df = 31, p = 0.145) when controlled for the contralateral vAC FA. The correlation coefficients for this follow-up analysis were found to be significantly different between left and right vAC (Z = 2.310, p = 0.021). Poor white matter health in the vAC may be a biological mechanism for depressive symptoms in older adults with vascular disease. Further studies may corroborate that the right vAC plays a unique role in depressive symptom manifestation in cases where the white matter is preferentially affected, as is the case in AVD. This could lead to future targeting of the region for somatic antidepressant treatment, as well as the development of a precise approach for patients with white matter damage, which could produce significant improvement in quality of life, medical morbidity, and mortality.

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“…Presence of anxiety symptoms was defined by a positive response to any of the following questions: “In the past month, have you felt anxious or frightened?”; “Were there times lately that you felt anxious?”; “Are there special situations that make you anxious?”; and “Have you ever had attacks of fear or panic?”. Presence of anxiety symptoms is a potential confounder, because anxiety symptoms are frequently present in individuals with depression, and are associated with cerebrovascular disease independently of depression (27, 28). Gait speed, a measure of physical performance (29), was the time needed to walk 6 meters at a usual pace.…”

Section: Methodsmentioning

confidence: 99%

Cerebral Small Vessel Disease and Association With Higher Incidence of Depressive Symptoms in a General Elderly Population: The AGES-Reykjavik Study

Sloten¹,

Sigurðsson²,

Buchem³

et al. 2015

AJP

119

116

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Objective The vascular depression hypothesis postulates that cerebral small vessel disease (CSVD) leads to depressive symptoms via disruption of brain structures involved in mood regulation. However, longitudinal data on the association between CSVD and depressive symptoms are scarce. We investigated the association between CSVD and incident depressive symptoms. Methods Longitudinal data are from the AGES-Reykjavik study of 1,949 participants free of dementia and without baseline depressive symptoms (74.6 years/56.6% women). MRI markers of CSVD, detected at baseline (2002–2006) and follow-up (2007–2011), included white matter hyperintensity volume (WMHV), subcortical infarcts, cerebral microbleeds, Virchow-Robin spaces and total brain parenchyma volume. Incident depressive symptoms were defined by the 15-item Geriatric Depression Scale (GDS-15) score≥6 and(or) use of antidepressant medication. Results Depressive symptoms occurred in 10.1% of the participants. The association for a greater onset of depressive symptoms was significant for participants having a 1 standard deviation increase in WMHV over time, new subcortical infarcts, new Virchow-Robin spaces, a 1 standard deviation lower total brain volume at baseline, or a 1 standard deviation decreased total brain volume over time, after adjustments for cognitive function, socio-demographic and cardiovascular factors. Results were qualitatively similar when change in the GDS-15 over time was used as the outcome instead of incident depressive symptoms. Conclusions Most markers of progression of CSVD over time and some markers of baseline CSVD are associated with concurrently developing new depressive symptoms. This study supports the vascular depression hypothesis.

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White matter fractional anisotropy is inversely related to anxious symptoms in older adults with atherosclerosis

Cited by 11 publications

References 51 publications

Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes

Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes

Depressive symptoms related to low fractional anisotropy of white matter underlying the right ventral anterior cingulate in older adults with atherosclerotic vascular disease

Cerebral Small Vessel Disease and Association With Higher Incidence of Depressive Symptoms in a General Elderly Population: The AGES-Reykjavik Study

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