2019
DOI: 10.1176/appi.ajp.2019.18101212
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White Matter in Schizophrenia Treatment Resistance

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Cited by 52 publications
(57 citation statements)
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“…RVI is a simple correlation between an individual and the expected deficit pattern derived from a representative disease sample. 32 The RVI is calculated after correcting the regional traits for age and sex. Therefore, the aging-related increases in RVI-AD in patients support the heuristics of SZ as a progressive neurological disease with an elevated risk of dementia.…”
Section: Discussionmentioning
confidence: 99%
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“…RVI is a simple correlation between an individual and the expected deficit pattern derived from a representative disease sample. 32 The RVI is calculated after correcting the regional traits for age and sex. Therefore, the aging-related increases in RVI-AD in patients support the heuristics of SZ as a progressive neurological disease with an elevated risk of dementia.…”
Section: Discussionmentioning
confidence: 99%
“…DTI data were collected using a 3T Siemens MRI scanner. The clinical and DTI protocol information have been reported 32 and are further described in SI.…”
Section: Methodsmentioning
confidence: 99%
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“…Neuropathology of accelerated brain aging likely contributes to the severity of the cognitive deficits in patients that form the core of socioeconomic impairments in this illness (Kochunov et al, 2016b;Kelly et al, 2018;Kochunov et al, 2017). Previously, we have shown that white matter deficits are associated with cognitive deficits and treatment difficulty in SZ (Kochunov et al, 2019(Kochunov et al, , 2017(Kochunov et al, , 2016b and have hypothesized that accelerated white matter aging in SZ leads to development of cognitive deficits and disorder-specific deficit patterns .…”
Section: Introductionmentioning
confidence: 97%