White Matter Integrity in Individuals at High Genetic Risk of Bipolar Disorder

784. Structural Dysconnectivity of Key Cognitive and Emotional Hubs in Young People at High Genetic Risk for Bipolar Disorder

“…These regions recapitulate those reported to have reduced WM volume and density, and reductions in fractional anisotropy in prior studies of unaffected relatives of BD patients, 21,22,39,[49][50][51] in addition to those with established BD. 49,[52][53][54][55][56][57][58] The specific involvement of the IFG adds to a converging body of evidence from structural and functional studies of BD.…”

“…CN subjects were recruited via print and electronic media, and noticeboards in universities and local communities. Sample ascertainment and separate clinical assessments for younger (15)(16)(17)(18)(19)(20)(21) and older (22)(23)(24)(25)(26)(27)(28)(29)(30) age categories are provided in Perich et al 36 and in Supplementary Information 1.1. We pooled data across both age cohorts unless there was a specific correlation between a brain network measure and an age-specific clinical variable in either group.…”

“…19 A number of studies have revealed evidence of WM alterations in unaffected first-degree relatives, although the spatial distribution and extent of these impairments remains uncertain. [20][21][22][23][24][25] Although diffusion tensor imaging-derived indices have shed light on disturbances in specific WM pathways, such methods are insensitive to complex interactions among multiple brain regions. Developments in the acquisition of diffusion-weighted imaging and fibre-bundle reconstruction have allowed structural brain networks to be mapped with increased precision.…”

Effect of Variation in Diacylglycerol Kinase Eta (DGKH) Gene on Brain Function in a Cohort at Familial Risk of Bipolar Disorder

“…These findings have been described previously in this sample (Sprooten et al, 2011;Whalley et al, 2011). There were, however, no significant differences within the groups based on haplotype.…”

“…Individuals at high genetic risk of BD I (BDI) because of a close family history of the disorder and control subjects were recruited as part of the Scottish Bipolar Family Study that has been described in detail elsewhere (Sprooten et al, 2011;Whalley et al, 2011). To identify high-risk participants, caseloads of psychiatrists across Scotland were searched for individuals diagnosed with BDI.…”