White Matter Lesions in Patients with Idiopathic Normal Pressure Hydrocephalus and in an Age-matched Control Group: A Comparative Study

Krauss, Joachim K.; Regel, Jens P.; Vach, Werner; Orszagh, M.; Jüngling, Freimut D.; Bohus, Martin; Droste, Dirk W.

doi:10.1227/00006123-199703000-00011

Cited by 27 publications

(34 citation statements)

References 22 publications

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“…Moreover, PVH and DWMH in INPH are supposed to be correlated with the clinical outcome. In particular, in INPH, the severity of the white matter changes may correlate with the clinical symptoms [18], but there is no evidence of a correlation with the response to shunt operation [19,20]. In our study, the grade of PVH in the INPH group was significantly greater than those in the AD and NC groups.…”

Section: Discussioncontrasting

confidence: 54%

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Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus

et al. 2008

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The utility of measuring the corpus callosal angle (CA) for the diagnosis of idiopathic normal pressure hydrocephalus (INPH) was investigated. Three-dimensional magnetic resonance imaging (MRI) was performed in 34 INPH patients, 34 Alzheimer's disease (AD) patients, and 34 normal control (NC) subjects. Measurement of the CA on the coronal MR images of the posterior commissure perpendicular to the anteroposterior commissure plane was performed for all subjects. The CA of the INPH group (mean +/- SD, 66 +/- 14 degrees) was significantly smaller than those of the AD (104 +/- 15 degrees) and NC (112 +/- 11 degrees) groups. When using the threshold of the mean - 2SD value of the NC group (= 90 degrees), an accuracy of 93%, sensitivity of 97%, and specificity of 88% were observed for discrimination of INPH from AD patients. Measuring the CA helps in differentiating INPH patients from AD and normally aged subjects.

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Section: Discussioncontrasting

confidence: 54%

“…White matter changes including PVH and DWMH have often been observed in INPH patients compared to aged subjects but they are not sufficient for the diagnosis of INPH [16][17][18]. Moreover, PVH and DWMH in INPH are supposed to be correlated with the clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus

et al. 2008

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“…iNPH is often associated with cerebrovascular diseases and Alzheimer disease. The pathological features of BD [17], a relatively high incidence of ischemic white matter lesions [4,5,20,37] and vascular risk factors such as hypertension [19], are also associated with iNPH. Moreover, biopsy specimens from shunt operations or CSF pressure monitoring are often reported to show meningeal fibrosis, ischemic white matter changes or Alzheimer pathology [4,10].…”

Section: Discussionmentioning

confidence: 99%

Shunt-responsive parkinsonism and reversible white matter lesions in patients with idiopathic NPH

et al. 2008

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“…The prevalence of cerebrovascular disease and risk factors (such as hypertension) is high in patients with NPH [20,25,26]. The importance of ACE in circulatory homeostasis is well documented, and some studies have demonstrated the involvement of the renin angiotensin system in memory and cognition [2,7,46].…”

Section: Discussionmentioning

confidence: 99%

“…■ Key words Angiotensinconverting enzyme · ACE polymorphism · Normal-pressure hydrocephalus · Neuropsychology · Shunt · Outcome cular disease and its risk factors are more common among patients with NPH than among controls [20,25,26]. Moreover cerebrovascular disease is an indicator of poor prognosis for shunting [9,41].…”

Section: Introductionmentioning

confidence: 99%

Angiotensin I converting enzyme polymorphism effects in patients with normal pressure hydrocephalus syndrome before and after surgery

et al. 2005

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Previous reports have suggested an association between the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE), cardiovascular disease, and cognitive performance. Normal pressure hydrocephalus (NPH) is considered to be an example of reversible dementia although the clinical improvement after shunting varies from subject to subject. An association has been suggested between vascular risk factors and the development of NPH. The ACE plays a major role in vascular pathology and physiology. In the present study we investigated the distribution of an ACE gene insertion/deletion polymorphism in 112 patients diagnosed with NPH and in 124 controls. We also evaluated the role of this genetic polymorphism in cognitive functioning before and following surgery in a subgroup of 72 patients. No differences in genetic or allele distributions were found between patients and healthy subjects, but among patients, carriers of D/D or D/I genotypes obtained less cognitive benefit following shunt surgery, especially on measures of memory and frontal function. Our data support previous findings in other conditions indicating that possession of at least one D allele is associated with poorer cognitive performance.

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White Matter Lesions in Patients with Idiopathic Normal Pressure Hydrocephalus and in an Age-matched Control Group: A Comparative Study

Cited by 27 publications

References 22 publications

Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus

Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus

Shunt-responsive parkinsonism and reversible white matter lesions in patients with idiopathic NPH

Angiotensin I converting enzyme polymorphism effects in patients with normal pressure hydrocephalus syndrome before and after surgery

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