White matter metabolism differentiates schizophrenia and bipolar disorder: a preliminary PET study

Altamura, Alfredo Carlo; Bertoldo, Alessandra; Marotta, Giorgio; Paoli, R; Caletti, Elisabetta; Dragogna, Filippo; Buoli, Massimiliano; Baglivo, Valentina; Mauri, Massimo C.; Brambilla, Paolo

doi:10.1016/j.pscychresns.2013.08.011

Cited by 31 publications

(23 citation statements)

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“…Indeed, it has been consistently reported that psychosis is a trans-diagnostic dimension between in SZ and BD [62]. Both disorders share extensive similarities in terms of biological, clinical, genetic and neurocognitive factors, suggesting a continuous distribution of symptoms among the two disorders [62,63,64,65,66,67,68]. …”

Section: Discussionmentioning

confidence: 99%

The metabolic basis of cognitive insight in psychosis: A positron emission tomography study

et al. 2017

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The purpose of this study was to investigate the relationship between cognitive insight and cerebral metabolism in patients suffering from psychosis. The Beck Cognitive Insight Scale (BCIS) was administered to 63 patients with psychosis undergoing Positron Emission Tomography investigation. The sample was divided into two groups considering the BCIS score. Data were analyzed using Statistical Parametric Mapping. Results: patients with low insight, compared to those with high insight, showed decreased metabolism in the right fusiform gyrus, left precuneus, superior temporal gyrus and insula bilaterally, as well as increased metabolism in the left orbito-frontal gyrus (all p<0.005). Our results suggest that reduced posterior (occipito-temporo-insulo-parietal) and increased anterior (orbitofrontal) cerebral metabolism may sustain low cognitive insight in psychosis.

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Section: Discussionmentioning

confidence: 99%

The metabolic basis of cognitive insight in psychosis: A positron emission tomography study

et al. 2017

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“…A few works also reported occipito-parietal deficits associated with SCZ, mainly in lingual gyrus and precuneus (McDonald et al 2005;Ivleva et al 2012), as well as deficits in cingulum (Ivleva et al 2013) and subgenual cortex (Yuksel et al 2012). The widespread GM deficits emerged from these studies may be related to the lower WM metabolism in frontal, parietal and temporal areas characterising SCZ in comparison with BD (Altamura et al 2013).…”

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confidence: 91%

Neuroanatomical voxel-based profile of schizophrenia and bipolar disorder

Maggioni

Altamura

Brambilla

2016

Epidemiol Psychiatr Sci

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This Section of Epidemiology and Psychiatric Sciences appears in each issue of the Journal to stress the relevance of epidemiology for behavioral neurosciences, reporting the results of studies that explore the use of an epidemiological approach to provide a better understanding of the neural basis of major psychiatric disorders and, in turn, the utilisation of the behavioural neurosciences for promoting innovative epidemiological research.The ultimate aim is to help the translation of most relevant research findings into every-day clinical practice. These contributions are written in house by the journal's editorial team or commissioned by the Section Editor (no more than 1000 words, short unstructured abstract, 4 key-words, one Table or Although schizophrenia (SCZ) and bipolar disorder (BD) share elements of pathology (Ellison-Wright and Bullmore, 2009), the neural mechanisms underlying these disorders are still under investigation. Up until now, many neuroimaging studies investigated the brain structural differences of SCZ and BD compared with healthy controls (HC), trying to identify the possible neuroanatomical markers for the two disorders. However, just a few studies focused on the brain structural changes between the two diagnoses. The present review summarises the findings of the voxel-based grey matter (GM) comparisons between SCZ and BD, with the objective to highlight the possible consistent anatomical differences between the two disorders. While the comparisons between patients and HC highlighted overlapping areas of GM reduction in insula and anterior cingulate cortex, the SCZ-BD comparisons suggest the presence of more generalised GM deficits in SCZ compared with BD. Indeed, in a number of studies, SCZ patients showed lower GM volumes than BD patients in fronto-temporal cortex, thalamus, hippocampus and amygdala. Conversely, only a couple of studies reported GM deficits in BD compared with SCZ, both at the level of cerebellum. In summary, the two disorders exhibit both common and specific neuroanatomical characteristics, whose knowledge is mandatory to develop innovative diagnostic and treatment strategies. (Email: marcella.bellani@univr.it; paolo.brambilla1@unimi.it)Epidemiology and Psychiatric Sciences (2016), 25, 312-316.

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“…[ 18 F]FDG PET has also been used to investigate the effects of antipsychotic drugs [220][221][222][223], cannabis use [224,225] and auditory verbal hallucinations [226,227] on the pattern of cerebral glucose metabolism in schizophrenia and to differentiate it from the pattern in bipolar disorder [228]. A hypothesis for pathogenesis of schizophrenia based on impaired neuronal glucose uptake by GLUT1…”

Section: Schizophreniamentioning

confidence: 99%

Roles of facilitative glucose transporter GLUT1 in [18F]FDG positron emission tomography (PET) imaging of human diseases

Patching¹

2015

J Diagn Imaging Ther

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The facilitative glucose transport protein GLUT1 has important roles in positron emission tomography (PET) imaging of human diseases. GLUT1 has widespread expression and catalyses the energyindependent facilitated diffusion of glucose down its concentration gradient across red blood cell membranes, blood-brain and blood-tissue barriers and membranes of some oragnelles. Import is usually the prevailing direction of transport for providing metabolic fuel, especially in proliferating cells. PET imaging using 2-deoxy-2-[ 18

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White matter metabolism differentiates schizophrenia and bipolar disorder: a preliminary PET study

Cited by 31 publications

References 44 publications

The metabolic basis of cognitive insight in psychosis: A positron emission tomography study

The metabolic basis of cognitive insight in psychosis: A positron emission tomography study

Neuroanatomical voxel-based profile of schizophrenia and bipolar disorder

Roles of facilitative glucose transporter GLUT1 in [18F]FDG positron emission tomography (PET) imaging of human diseases

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