White matter microstructural abnormalities and their association with anticipatory anhedonia in depression

Yang, Xinhua; Wang, Yi; Wang, Dongfang; Tian, Kai; Cheung, Eric F. C.; Xie, Gary; Chan, Raymond C.K.

doi:10.1016/j.pscychresns.2017.04.005

Cited by 49 publications

(37 citation statements)

References 35 publications

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“…We were surprised to find that the other selected white matter pathways were not associated with PTA development. Anhedonia severity in depression has been previously linked to decrements in UF and CB integrity (Yang, X.H. et al, 2017), and both of these pathways have also been implicated in treatment outcomes for depression (Korgaonkar et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Structural connectivity and risk for anhedonia after trauma: A prospective study and replication

Fani

Michopoulos

Rooij

et al. 2019

Journal of Psychiatric Research

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Anhedonia emerges in some people after psychological trauma, reflected by a loss of interest, diminished affect, and detachment. Structural abnormalities in specific neural pathways at the time of trauma may influence the development of these posttraumatic anhedonia (PTA) symptoms. In this prospective study, we determined whether white matter connectivity at around one month post-trauma predicts PTA and other PTSD symptoms at six months post-trauma. Thirty men and women aged 19-62 were recruited from the emergency department of a Level I trauma center. Participants received diffusion tensor imaging at approximately one month post-trauma and clinical assessments at one and six months post-trauma. Probabilistic tractography was used to examine connectivity of select pathways. A replication sample (N = 57) in an independent, crosssectional dataset of traumatized women was similarly analyzed. Logistic regression results indicated that, after accounting for early PTSD symptoms (at one month) and other clinical risk factors, the integrity of the uncinate fasciculus (UF) uniquely predicted the presence of PTA at six months post-trauma (Beta = −225.6, p < .05). Together, these factors contributed to 76% of the variance in PTA. Integrity of the UF also predicted re-experiencing PTSD symptoms at six months post-trauma. These results were supported in our replication analyses. Our findings indicate that the integrity of the UF around 1 month post-trauma affects vulnerability for the development of anhedonic PTSD symptoms as well as re-experiencing symptoms. Connectivity of this amygdalaventromedial prefrontal pathway appears to be a salient predictor of anhedonia, above and beyond clinical risk factors.

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Section: Discussionmentioning

confidence: 99%

Structural connectivity and risk for anhedonia after trauma: A prospective study and replication

Fani

Michopoulos

Rooij

et al. 2019

Journal of Psychiatric Research

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“…Most recently, Bhatia, Henderson, Hsu, and Yim (2018) found reduced FA in the UF and cingulum bundle, specifically in portions of the tract connecting the sgACC and amygdala. Other studies have reported that reduced white matter integrity in the UF correlated with severity of depression (Zhang et al, 2012), anhedonia (Yang et al, 2017), and early life trauma (Hanson, Knodt, Brigidi, & Hariri, 2015).…”

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confidence: 90%

Multimodal imaging reveals a complex pattern of dysfunction in corticolimbic pathways in major depressive disorder

Nugent

Farmer

Evans

et al. 2019

Human Brain Mapping

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Major depressive disorder (MDD) is highly prevalent and associated with considerable morbidity, yet its pathophysiology remains only partially understood. While numerous studies have investigated the neurobiological correlates of MDD, most have used only a single neuroimaging modality. In particular, diffusion tensor imaging (DTI) studies have failed to yield uniform results. In this context, examining key tracts and using information from multiple neuroimaging modalities may better characterize potential abnormalities in the MDD brain. This study analyzed data from 30 participants with MDD and 26 healthy participants who underwent DTI, magnetic resonance spectroscopy (MRS), resting‐state functional magnetic resonance imaging (fMRI), and magnetoencephalography (MEG). Tracts connecting the subgenual anterior cingulate cortex (sgACC) and the left and right amygdala, as well as connections to the left and right hippocampus and thalamus, were examined as target areas. Reduced fractional anisotropy (FA) was observed in the studied tracts. Significant differences in the correlation between medial prefrontal glutamate concentrations and FA were also observed between MDD and healthy participants along tracts connecting the sgACC and right amygdala; healthy participants exhibited a strong correlation but MDD participants showed no such relationship. In the same tract, a correlation was observed between FA and subsequent antidepressant response to ketamine infusion in MDD participants. Exploratory models also suggested group differences in the relationship between DTI, fMRI, and MEG measures. This study is the first to combine MRS, DTI, fMRI, and MEG data to obtain multimodal indices of MDD and antidepressant response and may lay the foundation for similar future analyses.

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“…Given its complexity, its activity is closely associated to that of other main networks, such as the salience network, the emotional arousal network and the executive network (Gupta et al, 2015 ). Brain structural and functional connectivity changes in the reward system, closely resembling those observed in addiction (Michaud et al, 2017 ), have also been reported in obesity (Marqués-Iturria et al, 2015 ; Blechert et al, 2016 ; Carnell et al, 2017 ; Papageorgiou et al, 2017 ; Verdejo-Román et al, 2017 ), affecting several tracts (e.g., the anterior thalamic radiation, accumbofrontal fasciculus, forceps minor (FMi), cingulum, superior longitudinal fasciculus, inferior fronto-occipital fasciculus (Cho et al, 2013 ; Marqués-Iturria et al, 2015 ; Kullmann et al, 2016 ; Nangunoori et al, 2016 ; Papageorgiou et al, 2017 )) of the reward pathway (Sesack and Grace, 2010 ; Xu et al, 2012 ; Bracht et al, 2015 ; Yang et al, 2017 ). Only few studies, however, have investigated whether structural connectivity might be disrupted in people with genetic risk for obesity (Dennis et al, 2014 ; Spieker et al, 2015 ), reporting somewhat conflicting results.…”

Section: Introductionmentioning

confidence: 99%

“…We have investigated whether an association existed between genotype, body mass index (BMI) and diffusivity parameters of WM, reflective of WM microstructural integrity, in the “risk tracts” (anterior thalamic radiation and accumbofrontal fasciculi) and the “obesity-associated tracts” (FMi, cingulum, superior longitudinal fasciculus, inferior fronto-occipital fasciculus). These tracts were selected for their role in reward and punishment sensitivity (Sesack and Grace, 2010 ; Xu et al, 2012 ; Bracht et al, 2015 ; Yang et al, 2017 ), and for their involvement in obesity (Cho et al, 2013 ; Marqués-Iturria et al, 2015 ; Kullmann et al, 2016 ; Nangunoori et al, 2016 ; Papageorgiou et al, 2017 ). Moreover, we explored whether WM diffusivity could be related to specific personality traits in terms of punishment and reward sensitivity, as measured by the BIS/BAS (Carver and White, 1994 ) questionnaire.…”

Section: Introductionmentioning

confidence: 99%

Disruption of Accumbens and Thalamic White Matter Connectivity Revealed by Diffusion Tensor Tractography in Young Men with Genetic Risk for Obesity

Olivo

Latini

Wiemerslage

et al. 2018

Front. Hum. Neurosci.

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Background: Neurovascular coupling is associated with white matter (WM) structural integrity, and it is regulated by specific subtypes of dopaminergic receptors. An altered activity of such receptors, highly expressed in reward-related regions, has been reported in carriers of obesity-risk alleles of the fat mass and obesity associated (FTO) gene. Among the reward-related regions, the thalamus and the nucleus accumbens are particularly vulnerable to blood pressure dysregulation due to their peculiar anatomo-vascular characteristics, and have been consistently reported to be altered in early-stage obesity. We have thus hypothesized that a disruption in thalamus and nucleus accumbens WM microstructure, possibly on neurovascular basis, could potentially be a predisposing factor underlying the enhanced risk for obesity in the risk-allele carriers.Methods: We have tested WM integrity in 21 male participants genotyped on the FTO risk single nucleotide polymorphisms (SNP) rs9939609, through a deterministic tractography analysis. Only homozygous participants (9 AA, 12 TT) were included. 11 tracts were selected and categorized as following according to our hypothesis: “risk tracts”, “obesity-associated tracts”, and a control tract (forcpes major). We investigated whether an association existed between genotype, body mass index (BMI) and WM microstructural integrity in the “risk-tracts” (anterior thalamic radiation and accumbofrontal fasciculus) compared to other tracts. Moreover, we explored whether WM diffusivity could be related to specific personality traits in terms of punishment and reward sensitivity, as measure by the BIS/BAS questionnaire.Results: An effect of the genotype and an interaction effect of genotype and BMI were detected on the fractional anisotropy (FA) of the “risk tracts”. Correlations between WM diffusivity parameters and measures of punishment and reward sensitivity were also detected in many WM tracts of both networks.Conclusions: A disruption of the structural connectivity from the nucleus accumbens and the thalamus might occur early in carriers of the FTO AA risk-allele, and possibly act as a predisposing factor to the development of obesity.

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White matter microstructural abnormalities and their association with anticipatory anhedonia in depression

Cited by 49 publications

References 35 publications

Structural connectivity and risk for anhedonia after trauma: A prospective study and replication

Structural connectivity and risk for anhedonia after trauma: A prospective study and replication

Multimodal imaging reveals a complex pattern of dysfunction in corticolimbic pathways in major depressive disorder

Disruption of Accumbens and Thalamic White Matter Connectivity Revealed by Diffusion Tensor Tractography in Young Men with Genetic Risk for Obesity

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