White Matter Microstructural Integrity and Cognitive Function in a General Elderly Population

Vernooij, Meike W.; Ikram, M. Arfan; Vrooman, Henri A.; Wielopolski, Piotr A.; Krestin, Gabriël P.; Hofman, Albert; Niessen, Wiro J.; Lugt, Aad van der; Breteler, Monique M.B.

doi:10.1001/archgenpsychiatry.2009.5

Cited by 286 publications

(276 citation statements)

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“…Although we cannot assume causality, white matter damage is well described in brain injuries, 13,39 and we have previously shown that retired symptomatic NFL athletes with cognitive impairment, depression, or both have compromised white matter integrity compared with either controls or asymptomatic retired NFL players. 30 In our voxelwise analysis, significant clusters within the athlete group were localized around the corpus callosum and its extending projections. The corpus callosum is a dense white matter structure that is structurally vulnerable to jarring or torsional forces that occur in head impacts.…”

Section: Discussionmentioning

confidence: 80%

“…Neuropsychological assessment included measures of general cognitive ability, attention, language, memory, visuospatial and executive function, and processing speed 30 prior to neuroimaging. The standard 60 item BNT 1 was used as a measure of visual confrontation naming.…”

Section: Neuropsychological Datamentioning

confidence: 99%

“…27,28 The degree of directionality of water diffusion is quantified as a scalar value, fractional anisotropy (FA), that distinguishes between abnormal and healthy white matter based on the cylindrical patterns of the diffusion. White matter pathway disruption as assessed by FA has been correlated with performance on some neuropsychological tasks, 16,29,30 including naming performance. 31 Professional football players who experienced subconcussive head impacts 32,33 may be susceptible to increased risk for progressive cognitive decline and affective disorders 34,35 with aging.…”

Section: Introductionmentioning

confidence: 99%

“…30 We anticipated that these findings would also provide insight into the differential vulnerability of any such regions to the type of injuries typically experienced by these athletes and, therefore, into the specific cognitive subcomponents of naming that may be most affected.…”

Section: Introductionmentioning

confidence: 99%

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White Matter Changes and Confrontation Naming in Retired Aging National Football League Athletes

Strain

Didehbani

Spence

et al. 2017

Journal of Neurotrauma

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Using diffusion tensor imaging (DTI), we assessed the relationship of white matter integrity and performance on the Boston Naming Test (BNT) in a group of retired professional football players and a control group. We examined correlations between fractional anisotropy (FA) and mean diffusivity (MD) with BNT T-scores in an unbiased voxelwise analysis processed with tract-based spatial statistics (TBSS). We also analyzed the DTI data by grouping voxels together as white matter tracts and testing each tract's association with BNT T-scores. Significant voxelwise correlations between FA and BNT performance were only seen in the retired football players ( p < 0.02). Two tracts had mean FA values that significantly correlated with BNT performance: forceps minor and forceps major. White matter integrity is important for distributed cognitive processes, and disruption correlates with diminished performance in athletes exposed to concussive and subconcussive brain injuries, but not in controls without such exposure.

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Section: Discussionmentioning

confidence: 80%

Section: Neuropsychological Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

White Matter Changes and Confrontation Naming in Retired Aging National Football League Athletes

Strain

Didehbani

Spence

et al. 2017

Journal of Neurotrauma

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“…Future studies of the role of brain microvascular disease in late-life dementia are going to have to use a direct measure of microvascular disease that captures the pathology more precisely than current neuroimaging. Diffusion tensor imaging may be one strategy to better assess the impact of microvascular disease on brain white matter (23). Diffusion tensor imaging detects changes in normal-appearing white matter and might therefore be more sensitive and specific than white matter hyperintensities for pathology (23).…”

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confidence: 99%

Invited Commentary: Albuminuria and Microvascular Disease of the Brain--A Shared Pathophysiology

Knopman¹

2010

American Journal of Epidemiology

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This commentary considers the implications of the association between albuminuria and cognitive decline described by Jassal et al. in this issue of the Journal (Am J Epidemiol. 2010;171(3):290-291). The authors report that men with albuminuria had a greater likelihood than men without albuminuria of experiencing declines in cognitive function over a 6.6-year period. Albuminuria is the result of endothelial damage in the kidney, which, in turn, is the result of microvascular disease. If one of the key mechanisms of brain microvascular disease is leakage of serum proteins into the brain extracellular space, in a fashion parallel to albuminuria that occurs in nephrosclerosis, several facets of cerebrovascular disease and cognitive decline are explained. First, brain microvascular disease would not be recognized by traditional clinical features of cerebrovascular disease because brain microvascular disease occurs gradually and insidiously. Second, the extravasation of serum proteins as a result of brain microvascular disease would account for the perivascular distribution of white matter hyperintensities on magnetic resonance imaging. Albuminuria might be a useful screening test for generalized microvascular disease and, if detected, might reasonably prompt brain imaging and more intensive therapeutic efforts to forestall further endothelial dysfunction in the kidney, brain, and elsewhere. aged; albuminuria; cognition; dementia; dementia, vascularIn this issue of the Journal, Jassal et al. (1) report that, in a cohort of 1,345 elders, those men with albuminuria were more likely than men without albuminuria to experience declines in cognitive function over a 6.6-year interval. The association was not found for women. Their study has a number of strengths, including its longitudinal design, large sample size, and multi-instrument cognitive assessment battery. The lack of association between albuminuria and cognitive decline in women was puzzling, and not fully explained. Nonetheless, the associations between albuminuria and cognitive decline in men were very consistent across multiple analytic approaches. The findings of Jassal et al. add to a growing body of work (2-6) that supports an association in older persons between changes in kidney function and changes in brain function. Why is it that something in the urine has anything to do with brain function? The answer lies in how and why protein gets into the urine.More so than glomerular filtration rate, the relation between microalbuminuria and vascular diseases of the kidney holds unique insights relevant to cerebrovascular disease.Both the brain and the kidney are highly vascular structures that respond to diseases such as hypertension and diabetes mellitus in similar ways at the microscopic level. In nephrosclerosis, gradual alterations in the kidney endothelial cells, glomeruli, and interstitial spaces lead to glomerular leakage of serum proteins into the urine (7,8). If a similar process were occurring at the endothelial level in brain microvessels, serum protei...

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Translational Epidemiology in Psychiatry

Weissman

Brown²,

Talati³

2011

Arch Gen Psychiatry

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Translational research generally refers to the application of knowledge generated by advances in basic sciences research translated into new approaches for diagnosis, prevention, and treatment of disease. This direction is called bench-to-bedside. Psychiatry has similarly emphasized the basic sciences as the starting point of translational research. This article introduces the term translational epidemiology for psychiatry research as a bidirectional concept in which the knowledge generated from the bedside or the population can also be translated to the benches of laboratory science. Epidemiologic studies are primarily observational but can generate representative samples, novel designs, and hypotheses that can be translated into more tractable experimental approaches in the clinical and basic sciences. This bedside-to-bench concept has not been explicated in psychiatry, although there are an increasing number of examples in the research literature. This article describes selected epidemiologic designs, providing examples and opportunities for translational research from community surveys and prospective, birth cohort, and family-based designs. Rapid developments in informatics, emphases on large sample collection for genetic and biomarker studies, and interest in personalized medicine—which requires information on relative and absolute risk factors—make this topic timely. The approach described has implications for providing fresh metaphors to communicate complex issues in interdisciplinary collaborations and for training in epidemiology and other sciences in psychiatry.

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White Matter Microstructural Integrity and Cognitive Function in a General Elderly Population

Cited by 286 publications

References 59 publications

White Matter Changes and Confrontation Naming in Retired Aging National Football League Athletes

White Matter Changes and Confrontation Naming in Retired Aging National Football League Athletes

Invited Commentary: Albuminuria and Microvascular Disease of the Brain--A Shared Pathophysiology

Translational Epidemiology in Psychiatry

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