White matter microstructural properties correlate with sensorimotor synchronization abilities

Blecher, Tal; Tal, Idan; Ben-Shachar, Michal

doi:10.1016/j.neuroimage.2016.05.022

Cited by 34 publications

(16 citation statements)

References 116 publications

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“…Tracking was stopped if the FA value dropped below 0.15, or if the angle between the diffusion direction in the current tensor and the direction in the next tensor was greater than 30º. This produced a large set of fibers throughout the entire brain for each toddler.Fibers from step 1 that connect specific regions (e.g., the occipital lobes) of the two hemispheres through the CC were identified using pairs of homologous ROIs that were located in the white matter of the right and left hemispheres and a CC ROI in the mid sagittal plane, similarly to previous studies (Huang et al 2005; Dougherty et al 2007; Blecher et al 2016). The seven pairs of symmetrical ROIs were defined on the Montreal Neurological Institute (MNI) template (Fonov et al 2011) as follows:

Occipital tract – Two vertical ROIs included all white matter voxels located in the occipital lobe of coronal MNI slice #71 (Figure 1J, green).

Temporal tract – Two vertical ROIs included all white matter voxels located in the temporal lobe of coronal MNI slice #98 (Figure 1I, purple).

Posterior parietal tract – Two vertical ROIs included all white matter voxels located in the parietal lobe of coronal MNI slice #71 (Figure 1J, yellow).

Superior parietal tract – Two horizontal ROIs included all white matter voxels located in the parietal lobe of axial MNI slice #121 (Figure 1H, dark blue).

Posterior frontal tract – Two horizontal ROIs included white matter voxels located below the pre-central gyrus in the frontal lobe of axial MNI slice #121 (Figure 1H, pink).

Middle frontal – Two horizontal ROIs included all white matter voxels that were anterior to the pre-central gyrus in the frontal lobe of axial MNI slice #121 (Figure 1H, red).

Anterior frontal – Two vertical ROIs included all white matter voxels in the frontal lobe of coronal MNI slice #176 (Figure 1G, orange).

…”

Section: Methodsmentioning

confidence: 99%

Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers

Fingher

Dinstein

Ben-Shachar

et al. 2017

Cortex

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Interhemispheric functional connectivity abnormalities are often reported in autism and it is thus not surprising that structural defects of the corpus callosum (CC) are consistently found using both traditional MRI and DTI techniques. Past DTI studies however, have subdivided the CC into 2 or 3 segments without regard for where fibers may project to within the cortex, thus placing limitations on our ability to understand the nature, timing and neurobehavioral impact of early CC abnormalities in autism. Leveraging a unique cohort of 97 toddlers (68 autism; 29 typical) we utilized a novel technique that identified seven CC tracts according to their cortical projections. Results revealed that younger (<2.5 years old), but not older toddlers with autism exhibited abnormally low mean, radial, and axial diffusivity values in the CC tracts connecting the occipital lobes and the temporal lobes. Fractional anisotropy and the cross sectional area of the temporal CC tract were significantly larger in young toddlers with autism. These findings indicate that water diffusion is more restricted and unidirectional in the temporal CC tract of young toddlers who develop autism. Such results may be explained by a potential overabundance of small caliber axons generated by excessive prenatal neural proliferation as proposed by previous genetic, animal model, and postmortem studies of autism. Furthermore, early diffusion measures in the temporal CC tract of the young toddlers were correlated with outcome measures of autism severity at later ages. These findings regarding the potential nature, timing, and location of early CC abnormalities in autism add to accumulating evidence, which suggests that altered inter-hemispheric connectivity, particularly across the temporal lobes, is a hallmark of the disorder.

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Occipital tract – Two vertical ROIs included all white matter voxels located in the occipital lobe of coronal MNI slice #71 (Figure 1J, green).

Temporal tract – Two vertical ROIs included all white matter voxels located in the temporal lobe of coronal MNI slice #98 (Figure 1I, purple).

Posterior parietal tract – Two vertical ROIs included all white matter voxels located in the parietal lobe of coronal MNI slice #71 (Figure 1J, yellow).

Superior parietal tract – Two horizontal ROIs included all white matter voxels located in the parietal lobe of axial MNI slice #121 (Figure 1H, dark blue).

Posterior frontal tract – Two horizontal ROIs included white matter voxels located below the pre-central gyrus in the frontal lobe of axial MNI slice #121 (Figure 1H, pink).

Middle frontal – Two horizontal ROIs included all white matter voxels that were anterior to the pre-central gyrus in the frontal lobe of axial MNI slice #121 (Figure 1H, red).

Anterior frontal – Two vertical ROIs included all white matter voxels in the frontal lobe of coronal MNI slice #176 (Figure 1G, orange).

…”

Section: Methodsmentioning

confidence: 99%

Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers

Fingher

Dinstein

Ben-Shachar

et al. 2017

Cortex

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“…However, there is also evidence that neural differences in individuals who stutter may go beyond levels of activity in specific brain regions, additionally affecting connectivity between brain regions. Recent resting-state connectivity analyses suggest atypical functional brain organization in stuttering (Lu et al, 2009(Lu et al, , 2010Xuan et al, 2012;Chang et al, 2018), and white matter structure also seems to be affected (Jäncke et al, 2004;Watkins et al, 2008;Blecher et al, 2016;Kemerdere et al, 2016;Kronfeld-Duenias et al, 2016). Functional MRI analysis techniques like independent component analysis (ICA) can identify brain ''networks'' from fMRI data without resorting to seed regions or other a priori hypotheses.…”

Section: Introductionmentioning

confidence: 99%

Neural Correlates of Vocal Pitch Compensation in Individuals Who Stutter

Sares

Deroche

Ohashi

et al. 2020

Front. Hum. Neurosci.

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Stuttering is a disorder that impacts the smooth flow of speech production and is associated with a deficit in sensorimotor integration. In a previous experiment, individuals who stutter were able to vocally compensate for pitch shifts in their auditory feedback, but they exhibited more variability in the timing of their corrective responses. In the current study, we focused on the neural correlates of the task using functional MRI. Participants produced a vowel sound in the scanner while hearing their own voice in real time through headphones. On some trials, the audio was shifted up or down in pitch, eliciting a corrective vocal response. Contrasting pitch-shifted vs. unshifted trials revealed bilateral superior temporal activation over all the participants. However, the groups differed in the activation of middle temporal gyrus and superior frontal gyrus [Brodmann area 10 (BA 10)], with individuals who stutter displaying deactivation while controls displayed activation. In addition to the standard univariate general linear modeling approach, we employed a data-driven technique (independent component analysis, or ICA) to separate task activity into functional networks. Among the networks most correlated with the experimental time course, there was a combined auditory-motor network in controls, but the two networks remained separable for individuals who stuttered. The decoupling of these networks may account for temporal variability in pitch compensation reported in our previous work, and supports the idea that neural network coherence is disturbed in the stuttering brain.

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“…Huang et al 2005;Dougherty et al 2007;Blecher et al 2016). The seven pairs of symmetrical ROIs were defined on the Montreal Neurological Institute (MNI) template(Fonov et al 2011) as follows: a) Occipital tract -Two vertical ROIs included all white matter voxels located in the occipital lobe of coronal MNI slice #71 (Figure 1J, green).…”

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confidence: 99%

Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers

Fingher

Dinstein

Ben-Shachar

et al. 2017

Preprint

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White matter microstructural properties correlate with sensorimotor synchronization abilities

Cited by 34 publications

References 116 publications

Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers

Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers

Neural Correlates of Vocal Pitch Compensation in Individuals Who Stutter

Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers

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