White matter structural network alterations in congenital bilateral profound sensorineural hearing loss children: A graph theory analysis

Cui, Wenzhuo; Wang, Shanshan; Chen, Boyu; Fan, Guoguang

doi:10.1016/j.heares.2022.108521

Cited by 2 publications

(12 citation statements)

References 63 publications

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“…Thus, alteration in rich-club connections reflects the brain's global communications impairment (Stam, 2014;van den Heuvel & Sporns, 2011). Abnormalities in rich (i.e., hub-hub), feeder (i.e, hubnonhub), and local (i.e., nonhub-nonhub) connections have been reported previously in individuals with neurological disorders along with alteration in local topological metrics (Cui et al, 2022;Lou et al, 2021;Ray et al, 2014;Shu et al, 2018;B. Wang et al, 2021;Y.…”

Section: Rich-club Organization Is Intact In Apdmentioning

confidence: 65%

“…Rich-club organization is a key characteristic of brain networks, and its existence has not only been found during human brain development (Sa de Almeida et al, 2021;van den Heuvel & Sporns, 2011), but also in numerous neurological diseases (Cao et al, 2014;Collin, Kahn, et al, 2014;Cui et al, 2022;D. Li et al, 2020;Liu et al, 2021;Peng et al, 2021;Ray et al, 2014;.…”

Section: Rich-club Organization Is Intact In Apdmentioning

confidence: 99%

“…The strength of local connections in the SNHL group was significantly higher than in HC. However, there were no differences in rich and feeder connections (Cui et al, 2022). The authors concluded that the alteration in information transmission did not modify the global topology, and the increased local connection may result from insufficient synaptic pruning caused by hearing deprivation (Cui et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…However, there were no differences in rich and feeder connections (Cui et al, 2022). The authors concluded that the alteration in information transmission did not modify the global topology, and the increased local connection may result from insufficient synaptic pruning caused by hearing deprivation (Cui et al, 2022). Thus, investigating the brain hub and rich-club organization of children with APD may advance our understanding of the pathobiology of this neurodevelopmental disorder.…”

Section: Introductionmentioning

confidence: 99%

“…The rich-club topology can provide important information for integrated communication in brain networks (Colizza et al, 2006; van den Heuvel & Sporns, 2011). Consequently, studying the topological architecture of a rich-club organization could uncover pathological bases for brain diseases (Daianu et al, 2015, 2014; Liu et al, 2021; Lu et al, 2021; Shu et al, 2018; Van Den Heuvel et al, 2013; Xue et al, 2020) and disorders (Cui et al, 2022; Keown et al, 2017; Lou et al, 2021; Ray et al, 2014; B. Wang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Altered structural connectome of children with Auditory Processing Disorder: A diffusion MRI study

Alvand

Kuruvilla-Mathew

Roberts

et al. 2022

Preprint

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Auditory processing disorder (APD) is a listening impairment that some school-aged children may experience as difficulty understanding speech in background noise despite having normal peripheral hearing. Recent resting-state functional magnetic resonance imaging (MRI) has revealed an alteration in regional, but not global, functional brain topology in children with APD. However, little is known about the brain structural organization in APD. We used diffusion MRI data to investigate the structural white matter connectome of 58 children from 8 to 14 years old diagnosed with APD (n=29) and children without hearing complaints (healthy controls, HC; n=29). We investigated the rich-club organization and structural connection differences between APD and HC groups using the network science approach. The APD group showed neither edge-based connectivity differences nor any differences in rich-club organization and connectivity strength (i.e., rich, feeder, local connections) compared to HCs. However, at the regional network level, we observed increased average path length (APL) and betweenness centrality in the right inferior parietal lobule and inferior precentral gyrus, respectively, in children with APD. HCs demonstrated a positive association between APL in the left orbital gyrus and the listening-in-spatialized-noise-sentences task, a measure of auditory processing ability. This correlation was not observed in the APD group. In line with previous functional connectome findings, the current results provide evidence for altered structural networks at a regional level in children with APD, and an association with listening performance, suggesting the involvement of multimodal deficits and a role for structure-function alteration in listening difficulties of children with APD.

show abstract

Section: Rich-club Organization Is Intact In Apdmentioning

confidence: 65%

Section: Rich-club Organization Is Intact In Apdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Altered structural connectome of children with Auditory Processing Disorder: A diffusion MRI study

Alvand

Kuruvilla-Mathew

Roberts

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Altered structural connectome of children with auditory processing disorder: a diffusion MRI study

et al. 2023

View full text Add to dashboard Cite

Auditory processing disorder (APD) is a listening impairment that some school-aged children may experience despite having normal peripheral hearing. Recent resting-state functional magnetic resonance imaging (MRI) has revealed an alteration in regional functional brain topology in children with APD. However, little is known about the structural organization in APD. We used diffusion MRI data to investigate the structural connectome of 58 children from 8 to 14 years old diagnosed with APD (n = 29) and children without hearing complaints (healthy controls, HC; n = 29). We investigated the rich-club organization and structural connection differences between groups. The APD group showed similar rich-club organization and edge-wise connection compared with the HC group. However, at the regional level, we observed increased average path length (APL) and betweenness centrality in the right inferior parietal lobule and inferior precentral gyrus, respectively, in the APD group. Only HCs demonstrated a positive association between APL and the listening-in-spatialized-noise-sentences task in the left orbital gyrus. In line with previous findings, the current results provide evidence for altered structural networks at the regional level in the APD group, suggesting the involvement of multimodal deficits and a role for structure-function alteration in the listening difficulties of children with APD.

show abstract

White matter structural network alterations in congenital bilateral profound sensorineural hearing loss children: A graph theory analysis

Cited by 2 publications

References 63 publications

Altered structural connectome of children with Auditory Processing Disorder: A diffusion MRI study

Altered structural connectome of children with Auditory Processing Disorder: A diffusion MRI study

Altered structural connectome of children with auditory processing disorder: a diffusion MRI study

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