White-matter tract abnormalities and antisocial behavior: A systematic review of diffusion tensor imaging studies across development

Waller, Rebecca; Dotterer, Hailey L.; Murray, Leigh; Maxwell, Andrea M.; Hyde, Luke W.

doi:10.1016/j.nicl.2017.01.014

Cited by 91 publications

(120 citation statements)

References 93 publications

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“…The inclusion of youths can be defined based on different diagnostic criteria; some studies investigated only oppositional defiant disorder, while others focused on conduct disorder or a mixture of both. These heterogeneities were previously mentioned in a recent review 38 , however, we suggest another important factor in antisocial behavior, namely sex. So far, most DTI studies have included only male or mixed-gender groups of youths with antisocial behavior.…”

Section: Altered White Matter Structures In Conduct Disordersupporting

confidence: 67%

What can be learned from white matter alterations in antisocial girls.

Menks¹

2017

J Neurol Neuromedicine

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Antisocial behavior in youths constitutes a major public health problem worldwide. Conduct disorder is a severe variant of antisocial behavior with higher prevalence rates for boys (12%) as opposed to girls (7%). A better understanding of the underlying neurobiological mechanisms of conduct disorder is warranted to improve identification, diagnosis, or treatment. Functional and structural neuroimaging studies have indicated several key brain regions within the limbic system and prefrontal cortex that are altered in youths with conduct disorder. Examining the structural connectivity, i.e. white matter fiber tracts connecting these brain areas, may further inform about the underlying neural mechanisms. Diffusion tensor imaging (DTI) is a non-invasive technique that can evaluate the white matter integrity of fiber tracts throughout the brain. To date, DTI studies have found several white matter tracts that are altered in youths with conduct disorder. However, a majority of these studies have focused on male or mixed-gender groups, and only a few studies have specifically investigated white matter alterations in girls with conduct disorder. Ultimately, studies that directly compare boys and girls with conduct disorder are necessary to identify possible sexual dimorphic neural alterations and developmental trajectories of conduct disorder in youths.

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Section: Altered White Matter Structures In Conduct Disordersupporting

confidence: 67%

What can be learned from white matter alterations in antisocial girls.

Menks¹

2017

J Neurol Neuromedicine

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“…However, diffusion tensor imaging (DTI) findings on white matter (WM) microstructure in youths with antisocial behavior have been inconsistent in both the nature and loci of reported effects. 5 Methodological factors, as well as demographic and clinical features of the samples, may have contributed to the inconsistent findings and lack of replication. 5 The current study used DTI to investigate WM microstructure in the largest sample of female and male youths with CD recruited to date, and compared them to age-and puberty-matched, typically developing (TD) female and male youths.…”

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confidence: 99%

“…5 Methodological factors, as well as demographic and clinical features of the samples, may have contributed to the inconsistent findings and lack of replication. 5 The current study used DTI to investigate WM microstructure in the largest sample of female and male youths with CD recruited to date, and compared them to age-and puberty-matched, typically developing (TD) female and male youths. Tract-based spatial statistics (TBSS) 6 were used to examine WM microstructure at the wholebrain level and within specific regions-of-interest (ROIs).…”

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confidence: 99%

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White Matter Microstructure in Youths With Conduct Disorder: Effects of Sex and Variation in Callous Traits

Rogers

Gonzalez-Madruga

Kohls

et al. 2019

Journal of the American Academy of Child & Adolescent Psych

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Objective: Studies using diffusion tensor imaging (DTI) to investigate white matter (WM) microstructure in youths with conduct disorder (CD) have reported disparate findings. We investigated WM alterations in a large sample of youths with CD, and examined the influence of sex and callousunemotional (CU) traits. Method: DTI data were acquired from 124 youths with CD (59 female) and 174 typically developing (TD) youths (103 female) 9 to 18 years of age.Tract-based spatial statistics tested for effects of diagnosis and sex-by-diagnosis interactions. Associations with CD symptoms, CU traits, a task measuring impulsivity, and the impact of comorbidity, and age-and puberty-related effects were examined. Results: Youths with CD exhibited higher axial diffusivity in the corpus callosum and lower radial diffusivity and mean diffusivity in the anterior thalamic radiation relative to TD youths. Female and male youths with CD exhibited opposite changes in the left hemisphere within the internal capsule, fornix, posterior thalamic radiation, and uncinate fasciculus. Within the CD group, CD symptoms and callous traits exerted opposing influences on corpus callosum axial diffusivity, with callous traits identified as the unique clinical feature predicting higher axial diffusivity and lower radial diffusivity within the corpus callosum and anterior thalamic radiation, respectively. In an exploratory analysis, corpus callosum axial diffusivity partially mediated the association between callous traits and impulsive responses to emotional faces. Results were not influenced by symptoms of comorbid disorders, and no age-or puberty-related interactions were observed. Conclusion: WM alterations within the corpus callosum represent a reliable neuroimaging marker of CD. Sex and callous traits are important factors to consider when examining WM in CD.

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“…The specific externalizing factor demonstrated the most widespread pattern of correlations, with significant negative associations between this factor and AD in the splenium of the CC, anterior corona radiata (ACR), sagittal stratum (SS), and internal capsule (IC). Decreased integrity in all of these tracts has previously been implicated in case-control studies on antisocial personality disorder (Waller et al, 2017). This parallel is unsurprising given that the antisocial personality symptom dimension loads most highly of all disorders onto the externalizing factor, and as such, antisocial symptomatology is an important aspect of this specific second-order factor (Lahey et al, 2017b).…”

Section: Specific Externalizing Factor Correlatesmentioning

confidence: 91%

White Matter Microstructure Correlates of General and Specific Second-Order Factors of Psychopathology

Hinton

Lahey

Villalta-Gil

et al. 2018

Preprint

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Increasing data indicate that prevalent forms of psychopathology can be organized into secondorder dimensions based on their correlations, including a general factor of psychopathology that explains the common variance among all disorders and specific second-order externalizing and internalizing factors. Despite this organization, and high levels of comorbidity between diagnoses, most existing studies on the neural correlates of psychopathology employ case-control designs that treat diagnoses as independent categories. Thus, for instance, although perturbations in white matter microstructure have been identified across a range of disorders, the majority of such studies have used case-control designs, leaving it unclear whether observed relations reflect disorder specific characteristics, or transdiagnostic patterns. Using a representative community twin sample of 410 young adults, we tested the hypothesis that some relations between white matter microstructure properties in major tracts are related to secondorder factors of psychopathology. We examined fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). White matter correlates of all second-order factors were identified after controlling for multiple tests, including the general factor (FA in the body of the corpus callosum), specific internalizing (AD in the fornix), and specific externalizing (AD in the splenium of the corpus callosum, sagittal stratum, anterior corona radiata, and internal capsule). These findings suggest that features of white matter within specific tracts are associated with broad transdiagnostic dimensions of psychopathology rather than being restricted to individual diagnostic categories.Keywords: white matter microstructure; p factor; general factor of psychopathology; bifactor model; dimensional psychopathology; second-order factors of psychopathology

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White-matter tract abnormalities and antisocial behavior: A systematic review of diffusion tensor imaging studies across development

Cited by 91 publications

References 93 publications

What can be learned from white matter alterations in antisocial girls.

What can be learned from white matter alterations in antisocial girls.

White Matter Microstructure in Youths With Conduct Disorder: Effects of Sex and Variation in Callous Traits

White Matter Microstructure Correlates of General and Specific Second-Order Factors of Psychopathology

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