White Sesame Seed Oil Mitigates Blood Glucose Level, Reduces Oxidative Stress, and Improves Biomarkers of Hepatic and Renal Function in Participants with Type 2 Diabetes Mellitus

Aslam, Farhan; Iqbal, Sanaullah; Nasir, Muhammad; Anjum, Aftab Ahmad

doi:10.1080/07315724.2018.1500183

Cited by 44 publications

(53 citation statements)

References 42 publications

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“…Its consumption is associated with the reduction in oxidative stress, arteriosclerosis, hypercholesterolemia, and hepatic steatosis [2,7,17,21]. In contrast, sesame oil, besides high quantities of PUFAs, contains lignans of sesamin, sesamolin, and homologues to tocopherol, which are related to improvement in the lipidic profile, reduction of blood glucose, and anti-inflammatory and antiproliferative properties in carcinogenic cells [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of α-Linolenic Acid on Non-Alcoholic Hepatic Steatosis and Interleukin-6 and -10 in Wistar Rats

et al. 2019

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Consumption of omega-3 (n-3) polyunsaturated fatty acids (PUFA) is related to improvement in the inflammatory response associated with decreases in metabolic disorders of obesity, such as low-grade inflammation and hepatic steatosis. Linseed (Linum usitatissimum) oil is a primary source of n-3 fatty acids (FAs) of plant origin, particularly α-linolenic acid, and provides an alternative for the ingestion of n-3 PUFA by persons allergic to, or wishing to avoid, animal sources. In our study, we evaluated the effect of the consumption of different lipidic sources on metabolic and inflammatory parameters in Wistar rats. We split 56 male rats into four groups that were fed for 60 days with the following diets: sesame oil, (SO, Sesamum indicum), linseed oil (LO), SO + LO (SLO), and a control group (CG) fed with animal fat. Our results reveal that the use of LO or SLO produced improvements in the hepatic tissue, such as lower values of aspartate aminotransferase, liver weight, and hepatic steatosis. LO and SLO reduced the weight of visceral fats, weight gain, and mediated the inflammation through a decrease in interleukin (IL)-6 and increase in IL-10. Though we did not detect any significant differences in the intestine histology and the purinergic system enzymes, the consumption of α-linolenic acid appears to contribute to the inflammatory and hepatic modulation of animals compared with a diet rich in saturated FAs and or unbalanced in n-6/n-3 PUFAs, inferring possible use in treatment of metabolic disorders associated with obesity and cardiovascular diseases.

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Section: Introductionmentioning

confidence: 99%

Protective Effect of α-Linolenic Acid on Non-Alcoholic Hepatic Steatosis and Interleukin-6 and -10 in Wistar Rats

et al. 2019

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“…General characteristics of the included studies are reported in Table 1 . These studies were published between 2006 and 2020 and were conducted in Iran [ 14 , 25 , 26 , 28 ], India [ 16 , 27 ], Brazil [ 24 ], and Pakistan [ 15 ]. The age of the participants and the duration of intervention were 18–70 years and 6–12 weeks, respectively.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Sesame Consumption on Glycemic Control in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trial

Yargholi

Najafi

Zareian

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objectives. In recent years, diabetes has become a global health problem that creates a tremendous economic burden for many countries. Clinical trials evaluating the hypoglycemic effects of sesame consumption have produced conflicting results. This systematic review and meta-analysis was conducted to evaluate the effectiveness of sesame as a popular natural herb on glycemic indices in adults. Methods. The search for related articles in PubMed, Scopus, Google Scholar, and Cochrane library was conducted through May 2021. Results were reported as weighted mean differences (WMD) with 95% confidence intervals (CI) using a random-effects model. Results. A total of 605 studies were identified through online searching, and a total of eight RCTs representing 382 participants were included in this study. The meta-analyses revealed that sesame consumption significantly decreases serum fasting blood sugar (FBS): (WMD: −28.23 mg/dl; 95% CI (−39.16, −17.13), I2 = 97.6%; 95% CI (96, 98)), and hemoglobin A1c (HbA1c): (WMD: −1.00%; 95% CI (−1.11, −0.88), I2 = 0%; 95% CI (0, 79)) as compared to the control group. Conclusion. This study provides evidence of the hypoglycemic effects of sesame consumption, particularly in diabetic patients. Additional RCTs on sesame and its preparations should be conducted in different populations to increase generalizability.

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“…Significant reductions in the plasma total cholesterol, low-density lipoprotein cholesterol and triglycerides levels were noted in sesame oil therapies attributed to the high content of poly and monounsaturated fatty acids in sesame oil that are also rich in lignans that improve lipid profile. Furthermore, in a study involving 46 participants with type 2 diabetes, it was reported that diabetic patients who ingested sesame oil had significantly lower level of glucose and higher insulin compared with patients in the control after 90 days (Aslam et al, 2018). Also at 90 days, glycated haemoglobin (HbA1c) was found to be significantly lower in those with sesame oil treatment than the control and the biomarkers of liver, cardiac, and renal functions were improved significantly in diabetic patients who ingested sesame oil.…”

Section: Awareness On the Nutritional And Health Promoting Benefits Omentioning

confidence: 99%

Analysis of sesame seed production and export trends; challenges and strategies towards increasing production in Uganda

Wacal

Basalirwa

Okello-Anyanga

et al. 2021

OCL

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Sesame (Sesamum indicum L.) is one of the most ancient oilseed crops cultivated for its edible oil and uses in food. Sesame seeds are very nutritious and confer health benefits. However, its potential production in Uganda has not been fully realized. The objective of this review was to summarize the trends in sesame production, export quantity, export value, challenges, and strategies for sustainable sesame seed production in Uganda. The review revealed the sesame seed production and area harvested generally increased from 1996 to 2007 but significantly decreased between 2008 and 2018. The review also revealed that while the export quantities and values were low, they gradually increased from 2009 to 2016. The decreased production between 2008 and 2016 could have been due to challenges such as pests and diseases, loss of soil fertility, prolonged drought, poor agronomic practices, poor yielding varieties, and lack of access to credit. Therefore, it is recommended to improve breeding programs and soil management practices; strengthen agricultural credits and extension services to support marketing of sesame seeds; and improve agronomic practices and farmer knowledge on improved techniques such as sowing methods, plant spacing, intercropping practices, pests and disease control measures. These could boost sesame production in Uganda given the high domestic and global demand for sesame seeds and provide an opportunity to expand sesame production throughout Uganda. Research should focus on how to increase seed yield on farmers’ fields and bridge the yield gap between researchers and farmers while adopting good agronomic practices.

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White Sesame Seed Oil Mitigates Blood Glucose Level, Reduces Oxidative Stress, and Improves Biomarkers of Hepatic and Renal Function in Participants with Type 2 Diabetes Mellitus

Cited by 44 publications

References 42 publications

Protective Effect of α-Linolenic Acid on Non-Alcoholic Hepatic Steatosis and Interleukin-6 and -10 in Wistar Rats

Protective Effect of α-Linolenic Acid on Non-Alcoholic Hepatic Steatosis and Interleukin-6 and -10 in Wistar Rats

The Effects of Sesame Consumption on Glycemic Control in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trial

Analysis of sesame seed production and export trends; challenges and strategies towards increasing production in Uganda

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