Whitening Effect of Hizikia fusiformis Ethanol Extract and Its Fractions

Jeon, Myong Je; Kim, Mihyang; Jang, Hye-Ji; Lee, Seung-Woo; Kim, Jae-Hoon; Kim, Hyung-Suk; Lee, Sang-Hyeon

doi:10.5352/jls.2012.22.7.889

Cited by 13 publications

(4 citation statements)

References 25 publications

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“…Tyrosinase is present in epidermal melanocytes as well as in the pigment epithelia of the retina, iris, and ciliary body of the eye [ 19 ], and is one of the chief enzymes responsible for skin pigmentation in mammals. Melanin production can be inhibited by suppressing tyrosinase activity, thereby preventing the induction of melasma, freckles, and senile erythema [ 20 ]. Despite the many pharmacological capacities of coumarin, the skin protective property of coumarin has not yet been studied using gamma irradiation for tyrosinase inhibitory potential.…”

Section: Resultsmentioning

confidence: 99%

Novel Dihydrocoumarins Induced by Radiolysis as Potent Tyrosinase Inhibitors

Jeong,

Yadav,

Lee

et al. 2024

Molecules

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A representative naturally occurring coumarin, 4-methylumbelliferone (5), was exposed to 50 kGy of gamma ray, resulting in four newly generated dihydrocoumarin products 1–4 induced by the gamma irradiation. The structures of these new products were elucidated by interpretation of spectroscopic data (NMR, MS, [α]D, and UV). The unusual bisdihydrocoumarin 4 exhibited improved tyrosinase inhibitory capacity toward mushroom tyrosinase with IC50 values of 19.8 ± 0.5 μM as compared to the original 4-methylumbelliferone (5). A kinetic analysis also exhibited that the potent metabolite 4 had non-competitive modes of action. Linkage of the hydroxymethyl group in the C-3 and C-4 positions on the lactone ring probably enhances the tyrosinase inhibitory effect of 4-methylumbelliferone (5). Thus, the novel coumarin analog 4 is an interesting new class of tyrosinase inhibitory candidates that requires further examination.

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Section: Resultsmentioning

confidence: 99%

Novel Dihydrocoumarins Induced by Radiolysis as Potent Tyrosinase Inhibitors

Jeong,

Yadav,

Lee

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

“…Tyrosinase is one of the enzymes responsible for skin pigmentation in mammals. Melanin production can be inhibited by inhibiting the tyrosinase activity, thereby preventing the induction of melasma, freckles, and senile erythema [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Inhibitory Effects of Coumarin Derivatives on Tyrosinase

Roh

2021

Molecules

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In this study, a series of coumarin derivatives were synthesized and their inhibitory effects on the activity of mushroom tyrosinase were evaluated. As a result of measuring the inhibition of tyrosinase activity of these derivatives, the compounds 3e (1.05 μM), 3f (0.83 μM), 3h (0.85 μM), 3i (1.05 μM), and 3k (0.67 μM) of the geranyloxycoumarin derivatives were highly active at a concentration of 0.8%. The geranyloxycoumarin derivatives exhibited better activity than the hydroxycoumarin derivatives. Among the geranyloxycoumarin derivatives, compound 3k was two times more active than arbutin, a positive control, at a concentration of 0.4%. The above results suggest that geranyloxycoumarin derivatives have great potential for application as functional cosmetic ingredients with tyrosinase-inhibiting activity.

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“…By measuring the absorbance at 405 nm, the concentration of melanin liberated into the medium was evaluated by sampling the supernatant. The concentration of melanin in the cells was obtained by dissolving the cells in 1 M NaOH [24]. The determined melanin contents were normalized by the total protein content.…”

Section: Measurement Of Inhibitory Activity Of Melanin Biosynthesismentioning

confidence: 99%

The Assessment of the Skin-Whitening and Anti-Wrinkling Effects of Anemarrhena asphodeloides Bunge Root Extracts and the Identification of Nyasol in a Developed Cream Product

Lee

Jang²,

Choi

2023

Cosmetics

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Anemarrhena asphodeloides Bunge (A. asphodeloides Bunge) root extract contains nyasol as its main ingredient. Nyasol was extracted and prepared as a cosmetic raw material in 95% ethanol. To identify nyasol as a marker compound qualitative analysis was performed using ultra-performance liquid chromatographyi coupled with electrospray ionization–tandem mass spectrometry. Below a nyasol content of 12 μg/mL, the root extract exhibited negligible cytotoxicity. In this concentration range, melanin production in B16F10 mouse melanoma cells decreased as the concentration of nyasol increased, indicating a skin-whitening effect. In addition, an antiwrinkling effect was confirmed by evaluating the inhibition of MMP-1 protein expression in TNF-α-treated HaCaT cells by either A. asphodeloides Bunge root extract (>0.31 μg/mL) or nyasol (>0.25 μg/mL). High-performance liquid chromatography-coupled with a photodiode detector array was used to show that our extract contained 5.06 ± 0.01% nyasol. Furthermore, when this analysis method was applied for the quality control of a cream product containing 2 wt.% of A. asphodeloides Bunge root extract, the measured content of nyasol (0.1%) was over 90% of the nominal quantity. Therefore, the product was deemed to be within the required quality standards.

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Whitening Effect of Hizikia fusiformis Ethanol Extract and Its Fractions

Cited by 13 publications

References 25 publications

Novel Dihydrocoumarins Induced by Radiolysis as Potent Tyrosinase Inhibitors

Novel Dihydrocoumarins Induced by Radiolysis as Potent Tyrosinase Inhibitors

Inhibitory Effects of Coumarin Derivatives on Tyrosinase

The Assessment of the Skin-Whitening and Anti-Wrinkling Effects of Anemarrhena asphodeloides Bunge Root Extracts and the Identification of Nyasol in a Developed Cream Product

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