As a foundation to understanding how to be accessible and inclusive in TEL research, this chapter explores different conceptualisations of 'openness' and 'accessibility'. Using a range of examples, we then highlight how research projects take a particular orientation towards inclusiveness through their goals, methods and platforms. Technical accessibility, and opening up the potential to access education, are essential to an inclusive approach, but alone they rarely provide the basis for equitable learning. The examples therefore provide particular insights into how technological innovations need to be considered in concert with pedagogy. We then explore how our research has identified gaps and factors in digital inclusion for particular groups, and has been orientated towards designing for diverse audiences in response. An emphasis on processes and practices has emerged in both the accessibility and open education spaces, and we describe a practical example in which the OU has successfully embedded research-informed institutional practice through the Securing Greater Accessibility (SeGA) initiative.