Who benefits from cellular immune response during the Chagas disease?

Vega-Royero, S.; Sibona, G. J.

doi:10.1016/j.biosystems.2018.07.005

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…(a) Considerando solo la respuesta inmune humoral (figura tomada de [14]). (b) Considerando ambas respuestas inmunes: celular y humoral (figura tomada de [26]). Los valores de los parámetros están dados en la Tabla 1.…”

Section: Estados Estacionariosunclassified

Modelado Matemático de la Triponosomiasis Chagásica

Vega

Sibona

2019

Cienc. En Desarro.

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En este trabajo se presenta la extensión de un modelo que describe la interacción dinámica entre la respuestainmune de un mamífero y el parásito Trypanosoma cruzi durante la fase aguda de la enfermedad de Chagas.El modelo considera las respuestas inmunes celular y humoral, más los diferentes estados (intracelulary extracelular) del T. cruzi dentro de un anfitrión mamífero. Se analizan la evolución temporal de laspoblaciones, obteniendo diagramas de fase para determinar la estabilidad de los estados estacionarios entérminos de sus parámetros. El sistema arroja dos estados estacionarios, los cuales se asocian con los estadosde Curación y Cronicidad. El caso de muerte, obtenido cuando solo se considera la respuesta humoral,desaparece. La implicación fundamental de este resultado es el beneficio que produce la respuesta inmunecelular tanto para el anfitrión como para el parásito, puesto que permite extender la vida del anfitrión,alargando a la vez el estado crónico de la enfermedad sin destruir el habitat del parásito.

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Section: Estados Estacionariosunclassified

Modelado Matemático de la Triponosomiasis Chagásica

Vega

Sibona

2019

Cienc. En Desarro.

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“…The causative agent of Chagas disease Trypanosoma cruzi is an intracellular parasite that infects a variety of cells of the mammalian host [1,2]. The activation of adaptive immune response occurs by recruiting T lymphocytes to the infection sites after the presentation of trypomastigote/amastigote-related proteins via MHC-I or MHC-II [3,4].…”

Section: Introductionmentioning

confidence: 99%

CXCR3 chemokine receptor guides Trypanosoma cruzi-specific T-cells triggered by DNA/adenovirus ASP2 vaccine to heart tissue after challenge

et al. 2019

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CD8 + T lymphocytes play an important role in controlling infections by intracellular pathogens. Chemokines and their receptors are crucial for the migration of CD8 + T-lymphocytes, which are the main IFNγ producers and cytotoxic effectors cells. Although the participation of chemokine ligands and receptors has been largely explored in viral infection, much less is known in infection by Trypanosoma cruzi , the causative agent of Chagas disease. After T . cruzi infection, CXCR3 chemokine receptor is highly expressed on the surface of CD8 + T-lymphocytes. Here, we hypothesized that CXCR3 is a key molecule for migration of parasite-specific CD8 + T-cells towards infected tissues, where they may play their effector activities. Using a model of induction of resistance to highly susceptible A/Sn mice using an ASP2-carrying DNA/adenovirus prime-boost strategy, we showed that CXCR3 expression was upregulated on CD8 + T-cells, which selectively migrated towards its ligands CXCL9 and CXCL10. Anti-CXCR3 administration reversed the vaccine-induced resistance to T . cruzi infection in a way associated with hampered cytotoxic activity and increased proapoptotic markers on the H2K K -restricted TEWETGQI-specific CD8 + T-cells. Furthermore, CXCR3 receptor critically guided TEWETGQI-specific effector CD8 + T-cells to the infected heart tissue that express CXCL9 and CXCL10. Overall, our study pointed CXCR3 and its ligands as key molecules to drive T . cruzi -specific effector CD8 + T-cells into the infected heart tissue. The unveiling of the process driving cell migration and colonization of infected tissues by pathogen-specific effector T-cells is a crucial requirement to the development of vaccine strategies.

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Who benefits from cellular immune response during the Chagas disease?

Cited by 2 publications

References 22 publications

Modelado Matemático de la Triponosomiasis Chagásica

Modelado Matemático de la Triponosomiasis Chagásica

CXCR3 chemokine receptor guides Trypanosoma cruzi-specific T-cells triggered by DNA/adenovirus ASP2 vaccine to heart tissue after challenge

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