The literature on global international relations (IR) has argued that the discipline develops in the footsteps of world politics, but no sustained at- tention has been given to more immediate causes such as the funders that pay for IR teaching and scholarship. These donor–recipient relations have only attracted the attention of authors interested in cultural hege- mony and those contributing to the recent historiography of IR. Among the latter, some have studied how during the Cold War the Rockefeller Foundation attempted to buttress classical realism in the United States and Western Europe. This article connects and moves forward IR histori- ography and the global IR literature by shedding light on philanthropic foundations’ attempts to further a specific IR theory—classical realism— and area studies in the global south. The article argues that world poli- tics influenced global IR, but this influence was mediated by highly con- tingent events. Even a proximate cause like science patronage, let alone “world politics,” is not a sufficient cause capable of determining IR the- ories and disciplinary boundaries. Donors may achieve some impact but only under specific circumstances such as the ones explored here, that is, the donor is a unitary actor determined to advance its agenda by resorting to conditionality, alternative donors and funding are scarce, the discipline is either poorly or not institutionalized, and the recipient perceives the donor’s preferences as legitimate. The article uses previously untapped, fine-grained, primary sources to unravel philanthropy’s impact on Latin America’s first IR center. Because science patronage is exposed to many sources of indeterminacy and to contingency, donors cannot determine scholarship, which makes cultural hegemony all but impossible. Still, IR scholars need to study their patrons to understand their discipline, in and outside Europe and the United States.