Who is the convict; COVID‐19 or corticosteroid? Late onset avascular necrosis of hips after COVID‐19. A case report with literature review

Abstract

AimAvascular necrosis (AVN) or osteonecrosis is characterized by death of bone tissue due to endothelial damage and vascular abnormality. Coronavirus can induce endothelial damage and abnormal blood clotting, so that COVID‐19 is known as a vascular disease. We aim to evaluate the relationship between AVN and COVID‐19.CaseHere we present a 39‐year old man with severe COVID‐19 and corticosteroid consumption who developed late onset AVN of both hips 20 month after COVID‐19.ConclusionAn awareness of the possible osteonecrosis for all physicians dealing with patients with musculoskeletal problems following COVID‐19 is necessary.

COVID‐19 vaccine triggers autoimmune disease? Possible mechanism and current evidence

“…16 Several investigations have substantiated the efficacy of antiviral medications such as Molnupiravir, Paxlovid, and Remdesivir in diminishing hospitalization rates and mortality stemming from COVID-19. 17,18 Furthermore, certain experiments have illuminated that baricitinib and corticosteroids when used as adjuvants, commonly prescribed for the management of autoimmune disorders, exhibited enhanced therapeutic efficacy among patients experiencing cytokine storms subsequent to COVID-19. 17,19,20 However, upon conducting a comprehensive literature review spanning from December 2021 to September 2023, it is evident that there remains a paucity of conclusive evidence pertaining to the relationship between antiviral medications and the reduction of subsequent autoimmune diseases in the context of COVID-19.…”