WHO reassesses appropriate body-mass index for Asian populations

Choo, Vivien

doi:10.1016/s0140-6736(02)09512-0

Cited by 274 publications

(213 citation statements)

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“…Esses achados estão de pleno acordo com outras observações na literatura no que se refere à gordura corporal, porém, são poucas as citações em relação ao perímetro da cintura e do quadril 24 . 0 80 75 70 65 60 55 50 45 40 100 100 90 90 80 80 70 70 60 60 50 50 40 A validade do uso do IMC como indicador de adiposidade em crianças vem sendo demonstrada em vários estudos 22,25 , porém, os limites ou pontos de corte do IMC de aplicação internacional, para o diagnóstico de sobrepeso e obesidade em crianças, têm sido contestados devido a variações raciais, segundo alguns autores 26,27 . No nosso meio, considerando o aspecto multirracial do povo brasileiro, os limites propostos parecem ter boa concordância com a adiposidade, pelo menos em escolares.…”

Section: Discussionunclassified

Diagnosis of overweight and obesity in schoolchildren: utilization of the body mass index international standard

Giugliano¹,

Melo²

2004

J Pediatr (Rio J)

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Objective: To evaluate the agreement between the body mass index international standard and body fat for the diagnosis of overweight and obesity in schoolchildren.Methods: 528 schoolchildren between 6 and 10 years of age, of both sexes, had their weight and height measured. They were then classified as normal, underweight, overweight or obese using the body fat index for age. Body fat was estimated based on the sum of triceps and subscapular, triceps and calf skinfold measurements and waist and hip circumference.Results: Overweight and obesity were found in 21.2% of the girls and 18.8% of the boys. The average percentage of body fat in the normal children (17.7%) was statistically different from that of overweight (27%) and obese (29.4%) children (p < 0.02). The average waist and hip circumference also differed significantly between normal boys and girls (56.9 cm and 67.7 cm) and overweight children (65.9 cm and 77 cm) (p < 0.01). There was no significant difference between groups in terms of average waist to hip ratio. The percentage of body fat , waist and hip circumference were significantly correlated with body mass index (p < 0.01).Conclusion: Body mass index for age was an adequate indicator of overweight and obesity in group studied, with a good agreement with body fat.J Pediatr (Rio J). 2004;80(2):129-34: BMI, skinfold measurements, waist circumference, hip circumference, waist to hip ratio. ResumoObjetivo: Avaliar a concordância entre o índice de massa corporal segundo padrão internacional e indicadores de adiposidade no diagnós-tico de sobrepeso e obesidade em escolares.Métodos: Avaliação de peso e estatura de 528 escolares, entre 6 e 10 anos, de ambos os sexos, seguida da classificação das crianças em eutróficas, com baixo peso, sobrepeso ou obesidade segundo índice de massa corporal por idade. A adiposidade foi estimada a partir da somatória das medidas das dobras cutâneas tricipital e subescapular, tricipital e da panturrilha medial e pelas circunferências da cintura e quadril.Resultados: A prevalência de sobrepeso e obesidade foi de 21,2% nas meninas e 18,8% nos meninos. A porcentagem de gordura corporal média nas crianças normais (17,7%) foi significativamente diferente da observada nas crianças com sobrepeso (27,0%) e obesidade (29,4%) (p < 0,02). As circunferências médias da cintura e quadril dos meninos e meninas eutróficos (56,9 cm e 67,7 cm) diferiu significativamente daqueles com sobrepeso (65,9 cm e 77 cm) (p < 0,01). Não houve diferença na razão cintura-quadril entre os grupos. A porcentagem de gordura corporal, a circunferência da cintura e a circunferência do quadril correlacionaram-se significativamente com o índice de massa corporal (p < 0,01).Conclusão: O uso do índice de massa corporal por idade, baseado em padrão internacional, mostrou-se adequado para o diagnóstico de sobrepeso e obesidade na faixa etária estudada, apresentando boa concordância com a adiposidade. ARTIGO ORIGINAL IntroduçãoA obesidade vem aumentando de forma alarmante, sendo considerada uma verdadeira epide...

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Section: Discussionunclassified

Diagnosis of overweight and obesity in schoolchildren: utilization of the body mass index international standard

Giugliano¹,

Melo²

2004

J Pediatr (Rio J)

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“…World Health Organization (WHO) BMI ranges were used to categorize subjects as normal weight (18.5-24.9 kg/m 2 in white and black subjects; 18.5-22.9 kg/m 2 in Asians), overweight (25.0-29.9 kg/m 2 in white and black subjects; 23.0-29.9 kg/m 2 in Asians), or obese (30.0 kg/m 2 and above). 19,20 The current recommendations for Asian BMI ranges 19 were used in this study.…”

Section: Methodsmentioning

confidence: 99%

Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH)

et al. 2005

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BACKGROUND: The brain endogenous cannabinoid system modulates reward and craving pathways and consequently may affect body weight. A naturally occurring missense polymorphism in the gene encoding fatty acid amide hydrolase (FAAH), the primary enzyme for inactivation of endocannabinoids, is associated with problem drug use. AIMS: To investigate the relationship between the FAAH cDNA 385 A/A (P129T) polymorphism and overweight disorders in subjects of multiple ethnic backgrounds attending a medical screening clinic. SUBJECTS: A total of 2667 subjects of white, black and Asian ancestry were genotyped and stratified by a standardized clinicbased assessment of body mass index (BMI, weight in kilograms/(height in meters) 2 or kg/m 2 ). METHODS: Subjects were genotyped for the FAAH cDNA 385 C-A polymorphism using allele-specific oligonucleotide hybridization methods by investigators blinded to all clinical information. BMI was calculated based on exact clinical measurements and World Health Organization ranges were used to stratify subjects. Statistical methods included the Fisher exact test, Mann-Whitney U-test and multivariable logistic regression analysis. RESULTS: The homozygous FAAH 385 A/A genotype was significantly associated with overweight and obesity in white subjects (P ¼ 0.005) and in black subjects (P ¼ 0.05) but not in a small group of Asians. The median BMI for all subjects was significantly greater in the FAAH 385 A/A genotype group compared to heterozygote and wild-type groups (P ¼ 0.0001). In white subjects, there was an increasing frequency of the FAAH 385 A/A genotype with increasing BMI categories of overweight (P ¼ 0.02) and obese (P ¼ 0.006) with the same trend in black subjects. CONCLUSIONS: These results suggest a role for the FAAH 385 A/A missense polymorphism as an endocannabinoid risk factor in overweight/obesity and may provide indirect evidence to support cannabinoid antagonist treatment strategies in overweight disorders.

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“…Asian patients on average have a lower body mass index and have different associations between body mass index, body fat percentage, and health risks compared with an American population. [31][32][33] It is unclear whether the pathophysiology of patients, including the role of sympathetic tone, in treatment-resistant, uncontrolled hypertension could be different in Asian patients. However, regardless of inherent racial differences, differences also existed between the 2 studies in terms of medications prescribed and the RDN procedure.…”

Section: P=0004mentioning

confidence: 99%

Effect of Catheter-Based Renal Denervation on Morning and Nocturnal Blood Pressure

et al. 2015

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U ncontrolled hypertension is associated with an increasing incidence of stroke, cardiovascular events such as myocardial infarction, peripheral artery disease, and end-stage renal disease across all ages, and ethnicities. [1][2][3][4][5] Detailed studies of blood pressure (BP) variability over 24 hours have further described an increased risk of cardiovascular events and stroke with elevated BP during the nighttime 6,7 and early morning hours. 8,9The sympathetic nervous system plays an active role in the modulation of BP, and its overactivation can lead to hypertension.10,11 Percutaneous catheter-based renal denervation (RDN) by radiofrequency ablation of the renal artery nerves has been shown to reduce central sympathetic activity 12,13 and BP in patients with uncontrolled hypertension. Although recently reported results from the Renal Denervation in Patients With Uncontrolled Hypertension (SYMPLICITY HTN-3) 14 and SYMPLICITY HTN-Japan (HTN-Japan) 15 clinical trials did not demonstrate superiority of RDN over pharmacological management of hypertension based on superiority analyses of office BP or 24-hour ambulatory BP measurements (ABPM), 14,15 further evaluation of the SYMPLICITY HTN-3 trial identified several potential confounding factors that may have impacted the overall results, including insufficient ablation attempts, insufficient 4-quadrant ablations, and antihypertensive medication changes. 16In contrast to the results of SYMPLICITY HTN-3, the recently reported prospective Renal Denervation for Hypertension (DENER HTN) 17 trial reported small but statistically significant reductions in ambulatory BP (though not office or home BP) in denervated patients compared with a nonblinded, randomized control group of patients with resistant hypertension treated with a stepped-care pharmacological strategy. These reductions included greater decreases in both daytime and nighttime ambulatory systolic BP in the denervated group.Abstract-High nighttime and early morning blood pressure (BP) have been associated with greater risk for cardiovascular events than high clinic or daytime BP. BP is typically highest in the rising hours, when morning activities typically begin. We examined the effect of renal denervation on morning (6:00-8:59 AM), daytime (9:00 AM-8:59 PM), and nighttime ( P=0.28), but the classes prescribed and changes in prescription varied by study. Among patients treated with renal denervation, although the number of ablation treatments were similar in both studies (11.2±2.8 versus 11.5±1.9, P=0.55), patients in SYMPLICITY HTN-3 were less likely to receive at least 1 four-quadrant ablation treatment (25% versus 82%, P<0.001). In SYMPLICITY HTN-3, compared with controls (n=159), patients treated with renal denervation (n=325) experienced a significantly greater change in morning (−7.3±19.8 mm Hg, P<0.001) and nighttime (−6.1±18.2 versus −1.6±19.7 mm Hg, P=0.02) but not daytime systolic BP (−7.2±16.2 versus −6.4±18.6 mm Hg, P=0.67). This same trend was observed in the pooled analysis with HTN-Japan. Re...

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WHO reassesses appropriate body-mass index for Asian populations

Cited by 274 publications

References 0 publications

Diagnosis of overweight and obesity in schoolchildren: utilization of the body mass index international standard

Diagnosis of overweight and obesity in schoolchildren: utilization of the body mass index international standard

Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH)

Effect of Catheter-Based Renal Denervation on Morning and Nocturnal Blood Pressure

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