Background: Child-care services during early childhood provide opportunities for social interactions that may facilitate children's learning of acceptable social behaviors. Furthermore, they may reduce exposure to family adversity for some children. The aim of this study was to determine whether intensity of exposure to child-care services prior to age 5 years has a beneficial effect on disruptive behavior problems during adolescence, and whether the effect is more pronounced for children from low socioeconomic families. Methods: N = 1,588 participants from the Qu ebec Longitudinal Study of Child Development were assessed 14 times from 5 months to 17 years. Intensity of child-care exposure was measured from 5 months to 5 years of age. Main outcomes were self-reported physical aggression and opposition from age 12 to 17 years. Family socioeconomic status (SES) was measured at 5 months. Factors explaining differences in child-care use were controlled using propensity score weights (PSW). Results: Children exposed to moderate-intensity child-care services (part-time child-care services before 1½ years and full time afterward) reported lower levels of physical aggression (d = À.11, p = .056) and opposition (d = À.14, p = .029) during adolescence compared to children exposed to low-intensity child-care services. A significant child care by SES interaction (p = .017) for physical aggression indicated that the moderate-intensity child-care effect was specific to children from low SES families (d = À.36, p = .002). No interaction with socioeconomic status was found for opposition. Conclusions: Moderate-intensity child-care services from infancy to school entry may prevent disruptive behavior during adolescence, especially for disadvantaged children.Perinatal child characteristics based on hospital records. Low birth weight (<2,500 g), small birth length and small head circumference at birth (<10th percentile), intrauterine growth retardation (<5th percentile, 5th-10th percentile,• Early childhood child care may reduce negative impacts of family adversity on disruptive behavior during adolescence.• There is evidence of a protective effect of early childhood child care for behavioral problems in early/middle childhood, but evidence of long-term effects is lacking.• We found that exposure to child care during early childhood was associated with a reduction of physical aggression and opposition during adolescence.• For physical aggression, the effect was specific to children from low socioeconomic status families.