The report of the Nineteenth National Congress of the Party clearly states that we will move faster to build Chinese universities into world-class universities and develop world-class disciplines as we work to bring out the full potential of higher education. Under the background of "Belt and Road" construction, higher education is a "connecting heart bridge" for communication and cooperation between countries, and also a "adhesive" for co-construction and sharing. It has unique and irreplaceable advantages in the construction of "Belt and Road". The construction of "B&R" provides a broader space for the development of higher education and puts forward new requirements. In the face of the opportunities and challenges of "B&R", colleges and universities should take the initiative and push forward pragmatically, especially in the areas that are important nodes, and should speed up their own development in striving to serve the national strategy. By analyzing "three major challenges" of foreign exchange and cooperation in colleges and universities under the strategy of "B&R ", this paper finds out the" five major paths "for colleges and universities to help" B&R ", and analyzes them in detail in order to promote the international development of higher education in colleges and universities and to help the construction of "B&R".