Whole blood in civilian transfusion practice: A review of the literature

Gammon, Richard R.; Meena‐Leist, Claire; Al Mozain, Nour; Cruz, Julie; Hartwell, Elizabeth; Lu, Wen; Karp, Julie Katz; Noone, Susan; Orabi, Mustafa; Tayal, Amit; Bocquet, Christopher; Tanhehco, Yvette

doi:10.1111/trf.17480

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Cited by 4 publications

(2 citation statements)

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“…Whole blood transfusion is performed using blood that is group O and has low titers of anti-A and anti-B antibodies. 3…”

Section: Whole Bloodmentioning

confidence: 99%

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Blood and Its Components

Cohn,

Shaz

2023

JAMA

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“…Whole blood transfusion is performed using blood that is group O and has low titers of anti-A and anti-B antibodies. 3…”

Section: Whole Bloodmentioning

confidence: 99%

“…Whole blood is increasingly used in the trauma setting because it is easier to rapidly transfuse a single unit of whole blood than individual units of each blood component. Whole blood transfusion is performed using blood that is group O and has low titers of anti-A and anti-B antibodies …”

Section: Whole Bloodmentioning

confidence: 99%

Blood and Its Components

Cohn,

Shaz

2023

JAMA

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Contemporary management of major haemorrhage in critical care

Maier,

Brohi,

Curry

et al. 2024

Intensive Care Med

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Low titer group O whole blood and risk of RhD alloimmunization: Rationale for use in Finland

Susila,

Ilmakunnas,

Lauronen

et al. 2024

Transfusion

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BackgroundPrehospital low‐titer group O whole blood (LTOWB) used for patients with life‐threatening hemorrhage is often RhD positive. The most important complication following RhD alloimmunization is hemolytic disease of the fetus and newborn (HDFN). Preceding clinical use of RhD positive LTOWB, we estimated the risk of HDFN due to LTOWB prehospital transfusion in the Finnish population.Study Design and MethodsWe collected data on prehospital transfusions in Tampere and Helsinki University Hospital areas. Using the mean of reported alloimmunization rates in trauma studies (24%) and a higher reported rate representing trauma patients of 13–50 years old (42.7%), we estimated the risk of HDFN and extrapolated it to the whole of Finland.ResultsWe estimated that in Finland, with the current prehospital transfusion rate we would see 1–3 cases of severe HDFN due to prehospital LTOWB transfusions every 10 years, and fetal death due to HDFN caused by LTOWB transfusion less than once in 100 years.DiscussionThe estimated risk of serious HDFN due to prehospital LTOWB transfusion in the Finnish population is similar to previous estimates. As Finland routinely screens expectant mothers for red blood cell antibodies and as the contemporary treatment of HDFN is very effective, we support the prehospital use of RhD positive LTOWB in all patient groups.

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Whole blood in civilian transfusion practice: A review of the literature

Cited by 4 publications

References 50 publications

Blood and Its Components

Blood and Its Components

Contemporary management of major haemorrhage in critical care

Low titer group O whole blood and risk of RhD alloimmunization: Rationale for use in Finland

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