Whole Blood Prepared via a Platelet-Sparing Leukoreduction Filtration System Preserves the Hemostatic Function for 21 Days: Early Results of a Pilot Study to Expand the Use of Whole Blood for Trauma in South America

Macia, Carmenza; Guzmán-González, Mónica; Hernández, E Vaz; Alcala, M Moran; García, Alberto; Caicedo, Yaset; Orlas, Claudia; Granados, Marcela; Parra, Michael W.; Delgado, Carlos Alberto Ordóñez

doi:10.1016/j.jamcollsurg.2020.08.156

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“…Its hemostatic property was also evaluated by thrombelastography, which demonstrated a slight prolongation in the initiation of the clot, but stable clot formation throughout. These preliminary results are the basis for the development of the WEBSTER randomized control clinical trial which will test this whole blood system, pioneering the application of whole blood in civilian trauma 49 .…”

Section: The Evidence For Whole Bloodmentioning

confidence: 99%

“…Su propiedad hemostática evaluada mediante la Tromboelastografía mostró una leve prolongación en la iniciación y progresión del coagulo, pero tiene una formación estable del coagulo finalmente. Estos resultados preliminares, son el sustento para el desarrollo del ensayo clínico, controlado, aleatorizado WEBSTER, el cual probará este sistema de sangre total, siendo pionero en el mundo en la conservación y aplicación de sangre total en trauma civil 49 .…”

Section: La Evidencia De Sangre Totalunclassified

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Whole Blood for Blood Loss: Hemostatic Resuscitation in Damage Control

et al. 2020

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Hemorrhagic shock and its complications are a major cause of death among trauma patients. The management of hemorrhagic shock using a damage control resuscitation strategy has been shown to decrease mortality and improve patient outcomes. One of the components of damage control resuscitation is hemostatic resuscitation, which involves the replacement of lost blood volume with components such as packed red blood cells, fresh frozen plasma, cryoprecipitate, and platelets in a 1:1:1:1 ratio. However, this is a strategy that is not applicable in many parts of Latin America and other low-and-middle-income countries throughout the world, where there is a lack of well-equipped blood banks and an insufficient availability of blood products. To overcome these barriers, we propose the use of cold fresh whole blood for hemostatic resuscitation in exsanguinating patients. Over 6 years of experience in Ecuador has shown that resuscitation with cold fresh whole blood has similar outcomes and a similar safety profile compared to resuscitation with hemocomponents. Whole blood confers many advantages over component therapy including, but not limited to the transfusion of blood with a physiologic ratio of components, ease of transport and transfusion, less volume of anticoagulants and additives transfused to the patient, and exposure to fewer donors. Whole blood is a tool with reemerging potential that can be implemented in civilian trauma centers with optimal results and less technical demand.

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Section: The Evidence For Whole Bloodmentioning

confidence: 99%

Section: La Evidencia De Sangre Totalunclassified