Whole blood viscosity in systemic sclerosis: a potential biomarker of pulmonary hypertension?

Şentürk, Bihter; Akdeniz, Bahri; Yilmaz, Mehmet Birhan; Kahraman, Buse Özcan; Acar, Berrin; Uslu, Sadettin; Bırlık, Merih

doi:10.1007/s10067-019-04603-4

Cited by 13 publications

(7 citation statements)

References 41 publications

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“…However, the search for more specific markers is in progress. The most recent studies have concerned expression of miRNA let-7d, Midkine and Follistatin-like 3 (FSTL3) proteins, ratios of Cu/Se and ceruloplasmin(CP) /Circulating selenoprotein P(SELE-NOP), and whole blood viscosity level [34,[37][38][39]. (Table 1)…”

Section: Discussionmentioning

confidence: 99%

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Biomarkers of Disease Activity in Systemic Sclerosis

et al. 2020

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Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and uncontrolled cutaneous and internal organs fibrosis. Diagnosis of SSc in an early phase can be difficult because of a lack of typical symptoms. The delay in diagnosis and treatment of SSc may lead to uncontrolled progression of the disease, thus identification of possible early indicators of skin and organ involvement to prevent their further damage is necessary. The aim of this study is to review the latest biomarkers of organ involvement in SSc. In patients with lung fibrosis lung-epithelial-derived surfactant protein (SP-D), the glycoprotein Krebs von den Lungen-6 (KL-6), and chemokine ligands 2, 4 and 18 (CCL2, CXCL4, CCL18) are elevated, while in patients with skin fibrosis serum levels of heat shock protein 27 (Hsp27), interleukin 16 (IL-16), and IgG–galactosylation ratio are increased. Adiponectin concentration is inversely correlated with the intensity of cutaneous fibrosis. Skin gene profiling also seems very promising. In patients with heart involvement increased serum levels of brain natriuretic peptide (BNP) are present, as well as raised Midkine and Follistatin-like 3 (FSTL3) proteins, ratios of Cu/Se and ceruloplasmin(CP) /Circulating selenoprotein P(SELENOP) and higher whole blood viscosity level. Elevated calprotectin levels are found in individuals with gastrointestinal involvement. Increased levels of chemerin and ARA autoantibodies are associated with renal involvement, whereas high levels of adhesion molecules are found in patients with scleroderma renal crisis (SRC). Currently there are no biomarkers in use that can specifically identify the early involvement of organs.

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Section: Discussionmentioning

confidence: 99%

“…A recent cohort study showed that higher whole blood viscosity levels in SSc patients can serve as an independent indicator for PAH development. However, this needs to be confirmed by further research [39].…”

Section: Heartmentioning

confidence: 91%

Biomarkers of Disease Activity in Systemic Sclerosis

et al. 2020

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“…The elevated levels of TP and ALB mean damaged liver function. Interestingly, Senturk et al reported a significantly higher level of plasma TP in pulmonary arterial hypertension patients . The decreasing effect on the content of TP is helpful to exert the antihypertensive effect. , Hiraoka et al discovered elevated levels of serum ALB in portal hypertension .…”

Section: Discussionmentioning

confidence: 99%

Metabolomics of Artichoke Bud Extract in Spontaneously Hypertensive Rats

Wang

Jiang

Liu³

et al. 2021

ACS Omega

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Hypertension adversely affects the quality of life in humans across modern society. Studies have attributed increased reactive oxygen species production to the pathophysiology of hypertension. So far, a specific drug to control the disease perfectly has not been developed. However, artichoke, an edible vegetable, plays an essential role in treating many diseases due to its potent antioxidant activities. The objective of this study is to evaluate the effect of artichoke bud extract (ABE) on heart tissue metabolomics of hypertensive rats. Spontaneously hypertensive rats and Wistar–Kyoto (WKY) rats were divided into six groups, then exposed to different doses comprising ABE, Enalapril Maleate, or 1% carboxylmethyl cellulose for 4 weeks. Their blood pressures were recorded at 0, 2, 3, and 4 weeks after the start of the test period. Thereafter, all rats were anesthetized, and blood was collected from their cardiac apexes. Then, we measured the levels for 15 kinds of serum biochemical parameters. An established orthogonal partial least square-discriminant analysis model completed the metabolomic analysis. Hypertensive rats in the ABE group exhibited well-controlled blood pressure, relative to those in the model group. Specifically, artichoke significantly lowered serum levels for total protein (TP), albumin (ALB), and uric acid (UA) in the hypertensive rats. This effect involved the action of eight metabolites, including guanine, 1-methylnicotinamide, p-aminobenzoic acid, NAD, NADH, uridine 5′-monophosphate, adenosine monophosphate, and methylmalonic acid. Collectively, these findings suggest that ABE may play a role in affecting oxidative stress and purine, nicotinate, and nicotinamide metabolism.

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“…3A). The viscosity range was selected as it spans the normal and abnormally high viscosities observed in healthy and patients with diseases, respectively (9). This suggested that probe activity is unlikely to be affected by changes in blood viscosity induced by changes to physiological functions or diseases (Fig.…”

Section: Effect Of Fluid Viscosity and Ph On The Responsiveness Of Thmentioning

confidence: 99%

The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients�

Zhao

et al. 2019

Exp Ther Med

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High levels of homocysteine (Hcy) is closely associated with the onset of cerebral infarction. The present study aimed to synthesize a novel Hcy probe based on Rhodamine B, named S1-4, a new compound that has not been previously reported. This probe exhibited good linear range under physiological fluid viscosity and pH; it has good selectivity for Hcy, and is able to avoid interference from other amino acids and metal ions. This probe can effectively measure the level of Hcy in the blood sera of healthy people and in patients with transient cerebral ischemia and cerebral infarction. However, satisfactory specificity and sensitivity to Hcy was not achieved according to receiver operating characteristic curve analysis. Overall, results from the present study suggested that following further optimization, this probe may be potentially applied in the diagnosis of cerebral infarction.

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Whole blood viscosity in systemic sclerosis: a potential biomarker of pulmonary hypertension?

Cited by 13 publications

References 41 publications

Biomarkers of Disease Activity in Systemic Sclerosis

Biomarkers of Disease Activity in Systemic Sclerosis

Metabolomics of Artichoke Bud Extract in Spontaneously Hypertensive Rats

The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients�

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